DETERMINATION OF ENVIRONMENTAL FACTORS ASSOCIATED WITH INFLAMMATORY BOWEL DISEASE IN KAZAKHSTAN: A CASE-CONTROL STUDY
bowel diseases (IBD) in the Western world, but similar studies have not yet been conducted in Kazakhstan.
The aim of this study was to examine environmental factors associated with IBD in the population of Kazakhstan.
Materials and methods. The case-control study was conducted at the Kazakh Research Institute of Cardiology and Internal Medicine, using a questionnaire survey to determine the associations of risk factors with IBD. The survey was conducted from October 2019 to January 2020. The study involved 65 patients with IBD and 173 respondents without this pathology. A logistic regression procedure was used to identify associations between risk factors and the presence of IBD.
Results. Factors associated with increased risk of developing IBD were: irregular eating habits (p = 0.043; OR = 3.61 [95% CI: 1.04-12.51]), consumption of fish and seafood (p = 0.000; OR = 15.77 [95% CI: 4.56-54.59]), consumption of frozen convenience foods (p = 0.018; OR = 4.62 [95% CI: 1.3-16.4]), meat-based diet (p = 0.029; OR = 3.2 [95% CI: 1.13-9.2]), use of NSAID except aspirin (p = 0.031; OR = 3.79 [95% CI: 1.13-12.69]), and smoking (p = 0.008; OR = 4.93 [95% CI: 1.52-15.98]). Other factors showed protective effect: Kazakh nationality (p = 0.011; OR = 0.18 [95% CI: 0.05-0.68]), consumption of milk (p = 0.000; OR = 0.08 [95% CI: 0.02-0.31]), consumption of alcoholic beverages (p = 0.000; OR = 0.04 [95% CI: 0.01-0.16]), and childhood viral infections (p = 0.042; OR = 0.52 [95% CI: 0.27-0.98]).
Conclusion. This study found that the environment plays an important role in modulating the subsequent risk of developing IBD.
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Ualiyeva A., Oshibayeva A., Kaibullayeva J. Determination of environmental factors associated with inflammatory bowel disease in Kazakhstan: a case-control study // Nauka i Zdravookhranenie [Science & Healthcare]. 2020, (Vol.22) 4, pp. 97-104. doi 10.34689/SH.2020.22.4.010Related publications:
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