MULTIFACTORIAL NEGATIVE ANTHROPOGENIC IMPACT AND THE IMMUNE SYSTEM IN ADULTS IN UST-KAMENOGORSK
Aim: Determination of the characteristics of immune reactivity in persons living in areas of Ust-Kamenogorsk with different levels of anthropogenic impact.
Materials and methods. The work was carried out in the period 2017-2019. on the territory of Ust-Kamenogorsk and Uralsk. Three objects were identified: Ulba district - the territory of maximum concentration of industrial pollutants, Oktyabrsky district (city center), KShT district) with a minimum risk of airborne pollution. The work included samples from persons over 18 and under 60 years old, permanently residing in the indicated territories. In total, 590 people took part in the study in Ust-Kamenogorsk, and 248 people in Uralsk. On the territory of object 1, 185 people lived, object 2 - 201 people and object 3 - 204 people.
Research methods: analytical assessment of the content of elements in environmental objects of the investigated settlements and in water bodies; the content of pollutants in the air; noise level. A study of the state of the immune system was carried out using a complex of informative methods in terms of indicators of the cellular, humoral and phagocytic links.
Research results. When compared with the control group, suppression of the cellular link of the immune system was noted, due to a decrease in the number of highly differentiated circulating lymphocytes of individual clusters of differentiation. In persons exposed to the highest cumulative level of negative anthropogenic influences, a decrease in the general status of humoral immunity was also determined against the background of a sharp increase in the content of circulating immune complexes in the blood. On the part of phagocytosis, inhibition of all investigated mechanisms was also noted, first of all, lysis of the phagocytosed substrate. In general, the complex negative influence of anthropogenic factors of an industrial city is primarily aimed at suppressing phylogenetically later and more complex defense systems, as well as at disrupting regulatory cellular mechanisms during the functioning of less differentiated defense systems.
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Abisheva A.A., Belikhina T.I., Kazimov M.S., Zhunusova T., Manarbekov Ye.M. Multifactorial negative anthropogenic impact and the immune system in adults in Ust-Kamenogorsk // Nauka i Zdravookhranenie [Science & Healthcare]. 2021, (Vol.23) 4, pp. 172-179. doi 10.34689/SH.2021.23.4.019Related publications:
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