OBSTRUCTIVE SLEEP APNEA AND COGNITIVE FUNCTION WITH TYPE 2 DIABETES MELLITUS: A HOSPITAL-BASED CASE-CONTROL STUDY
The aim of our study is to examine the effect of obstructive sleep apnea syndrome (OSAS) on the cognitive functions of the brain in patients with type 2 diabetes.
Materials and methods. The study involved patients with clinically and laboratory proven type 2 diabetes mellitus. The cases group (Group 1) included patients with OSAS. The control group (Group 2) included patients without OSAS. Sleep duration and quality were assessed using respiratory monitoring. OSAS was screened using a portable night monitor. Cognitive assessment is performed using the Montreal Cognitive Test (MoCA). Three MoCA subscales were analyzed: visual-constructive function, executive function, and orienting function.
Results. A total of 94 patients (58 women and 36 men, 61.7% vs 38.3%) took part in the study. The age ranged from 45 to 59 years. The MoCA subscales - visual-spatial and executive functions, Clock and Orientation, were lower in the main group compared to controls (p<0.05). In the control group, significant correlation between the MoCA indicator and BMI (r=0,39; p=0,015), waist circumference (r=0,48; p=0,002), neck circumference (positive) (r=0,33; p=0,040) and Hba1c (negative) was found. In the main group, 32.7% of participants had MoCA score below 26, in the control group - only 67.3%
Conclusion. Lower sleep efficiency is associated with lower cognitive function in patients with abnormal glucose tolerance. Whether sleep optimization may improve cognitive function in these patients should be explored.
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Shinalieva K.A., Kasenova A.S., Zhumabayev M.B., Abdrakhmanova M.G., Bekenova A.O., Madirova S.E. Obstructive sleep apnea and cognitive function with type 2 diabetes mellitus: a hospital-based case-control study // Nauka i Zdravookhranenie [Science & Healthcare]. 2023, (Vol.25) 1, pp. 94-99. doi 10.34689/SH.2023.25.1.012 Шиналиева К.А., Касенова А.С., Жумабаев М.Б., Абдрахманова М.Г., Бекенова А.О., Мадирова С.Е. Синдром обструктивного апноэ сна и когнитивной функции при сахарном диабете 2 типа: исследование случай-контроль // Наука и Здравоохранение. 2023. 1(Т.25). С. 94-99. doi 10.34689/SH.2023.25.1.012Related publications:
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