THE COMBINED EFFECT OF LOW-DOSE RADIATION AND HEAVY METALS ON THE OXIDATIVE STATUS IN THE ORGANS OF IMMUNOGENESIS AND ITS CORRECTION IN THE EXPERIMENT
The influence of ionizing radiation and heavy metals on the state of the organs of immunogenesis remains poorly understood. One of the negative effects may be the activation of free radical processes and damage to immunocompetent cells, as well as violations of their function.
Purpose of the study: Determination of indicators of lipid peroxidation and antioxidant protection under separate and combined effects on the body of a low dose of gamma radiation and lead oxide, including when corrected by a phytocomposition.
Materials and methods: Study design is experimental study "experiment-control" on animals. The studies were carried out on 300 white outbred mature rats, divided into 5 categories "experiment-control", 30 individuals each. The effects of gamma radiation at a dose of 0.2 Gy, PbO2 and K2Cr2O7 seeding for 14 days and a combination of irradiation with seeding, as well as the use of a phytocomposition for the prevention and correction of negative effects for 14 days, were carried out. The content of primary and secondary lipid peroxidation products in thymus and spleen tissues, as well as the activity of enzymes of the antioxidant system: glutathione peroxidase, glutathione reductase, and catalase, were studied.
Research results. An increase in the content of lipid peroxidation products was determined in all experimental groups against the background of multidirectional dynamics of enzyme activity. Long-term exposure caused more pronounced disturbances in all studied parameters. The greatest effect of activation of lipid peroxidation and inhibition of antioxidant mechanisms was found with combined exposure. There were features of the content of products and activity of enzymes depending on the studied tissues. The use of the phytocomposition did not lead to a complete normalization of the studied parameters, but provided partial compensation for the combined effects of ionizing radiation and heavy metals.
Conclusions:
1. Separate and combined effects on the body of ionizing radiation and metals with variable valence cause the activation of lipid peroxidation and multidirectional processes in the enzymatic link of the antioxidant system in the organs of immunogenesis.
2. The combined effect leads to a sharp increase in violations of all the studied parameters.
3. The use of the phytocomposition under the combined effect of ionizing radiation and metals of variable valence provides a significant prevention of lipid peroxidation disorders and antioxidant protection in the organs of immunogenesis.
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Nurmadiyeva G.Т., Kydyrmoldina A.Sh., Tokesheva G.M., Мusakhanova А.Е., Krykpayeva A.S., Amralinov Y.T., Karmen А.K., Zhetpisbaev B.А. The combined effect of low-dose radiation and heavy metals on the oxidative status in the organs of immunogenesis and its correction in the experiment // Nauka i Zdravookhranenie [Science & Healthcare]. 2023, (Vol.25) 1, pp. 140-151. doi 10.34689/SH.2023.25.1.018Related publications:
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