PREOPERATIVE USE OF PLATELET-RICH PLASMA FOR LIPOFILLING
Relevance: Lipofilling is becoming an increasingly popular method of reconstruction the volume of almost any part of the human body every day. However, the use of adipose tissue as a filler has its limitations in the long term in the form of a low percentage of fat graft survival as a result of fibrous replacement and apoptosis of fat cells.
Aim: the aim of this study was a comparative morphological assessment of the survival of a fat autograft in groups with a standard lipofilling protocol and with preimplantation treatment of the implantation zone with platelet-rich plasma in rabbits.
Methods: in this study, 24 male rabbits were used, who underwent subcutaneous implantation of a fat autograft in the auricle area. All cases were divided into 3 groups depending on the method of treatment with platelet-rich plasma. After 3 months (90 days) of exposure, a macroscopic and histological examination of the fat autograft was performed.
Results: in the group of preoperative treatment of the implantation zone and intraoperative autograft treatment, a statistically significant preservation of the volume and histological normal fat autograft was observed in comparison with the group without and only intraoperative treatment.
Conclusion: preimplantation use of platelet-rich plasma significantly improves the standard technique of intraoperative treatment, increases the survival of fat autograft by increasing angiogenesis with a decrease in the degree of hypoxic-ischemic, fibrotic and inflammatory damage in the implantation zone
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Pak I.L., Askarov M.S., Klyuev D.A., Kamyshansky E.K. Preoperative use of platelet-rich plasma for lipofilling // Nauka i Zdravookhranenie [Science & Healthcare]. 2023, (Vol.25) 3, pp. 55-63. doi 10.34689/SH.2023.25.3.007Related publications:
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