RETROSPECTIVE ANALYSIS OF WEST SYNDROME ON THE EXAMPLE OF CHILDREN'S CITY CLINICAL HOSPITAL No. 2 ALMATY CITY
Introduction. West syndrome is a rare and severe form of epilepsy that usually affects children in their first year of life. Despite extensive research, the pathogenesis and optimal treatment of this syndrome remain unclear. The optimal approach to the treatment of West syndrome remains a matter of debate, and the efficacy of different treatment strategies varies widely across studies.
Aim. To reveal gender and age characteristics and clinical and electro-radiological features of West's syndrome.
Materials and methods. The study included patients who met the ILAE criteria for the diagnosis of West syndrome.
Data was collected from medical records, including patient demographics, clinical presentation, EEG findings, neuroimaging studies, and treatment outcomes. Descriptive statistics were used to analyze the clinical characteristics of West syndrome in this population. Chi-square tests were used to assess associations between categorical variables. The Kaplan-Meier method was used to estimate time to seizure control, and a log-rank test was used to compare time to seizure control between different treatment groups.
Results. In this retrospective study, cases of West syndrome were analyzed in a children's city clinical hospital over a five-year period. The study aimed to evaluate the clinical characteristics, treatment outcomes, and comorbidities of West syndrome in this population. The results show that early diagnosis and appropriate treatment are critical to achieve favorable outcomes in West syndrome.
Conclusions. The study of clinical, electro-radiological characteristics indicates that the etiological structure is dominated by structurally acquired disorders of the brain, among which the leading etiology is hypoxic-ischemic brain damage due to cerebrovascular accident. In terms of further study of the impact of clinical, electro-radiological and genetic data on outcome using polynomial logistic or multilinear regression.
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Abdygalyk B.A., Lepesova M.M., Rabandiyarov M.R., Myrzalieva B.D., Zharkinbekova N.A. Retrospective analysis of West syndrome on the example of Children's City Clinical Hospital No. 2, Almaty city // Nauka i Zdravookhranenie [Science & Healthcare]. 2023, (Vol.25) 3, pp. 137-143. doi 10.34689/SH.2023.25.3.018Related publications:
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