THE ROLE OF SNCA GENE POLYMORPHISMS IN THE DEVELOPMENT OF CARDIAC AUTONOMIC NEUROPATHY IN INDIVIDUALS OF KAZAKH ETHNICITY
Cardiac autonomic neuropathy (CAN) occurs as a result of cardiac innervation impairment and leads to an increased risk of cardiovascular morbidity and mortality. There is evidence suggesting that alpha-synuclein protein (SNCA) plays a significant role in the pathogenesis of cardiac autonomic neuropathy, particularly in relation to heart rate variability, a major clinical manifestation.
The aim of this study was to investigate the association between two SNCA gene polymorphisms (rs2736990 and rs2737029) and cardiac autonomic neuropathy in the Kazakh population.
Materials and methods: A case-control study included 82 patients with cardiac autonomic neuropathy, including those with a diabetic etiology (case group), and 100 individuals without a diagnosis of cardiac autonomic neuropathy (control group). All participants were of Kazakh ethnicity. Two SNCA gene polymorphisms, rs2736990 and rs2737029, were investigated. Statistical analysis was performed using chi-square tests, odds ratio calculations with confidence intervals, and logistic regression (SPSS 26.0).
Results: Among the two SNCA gene polymorphisms studied, only rs2737029 was associated with cardiac autonomic neuropathy. According to our findings, in a recessive model, the CC genotype increased the odds of having cardiac autonomic neuropathy by almost 2 times (1.93 (1.06-3.53)). After adjusting for age and sex, the results remained significant. However, the association between rs2736990 polymorphism and cardiac autonomic neuropathy did not show statistical significance in any of the models (1.00 (0.63-1.59)).
Conclusions: Thus, the presence of the CC genotype of rs2737029 polymorphism in the SNCA gene may be a predisposing factor for the development of cardiac autonomic neuropathy, including the diabetic form. However, the rs2736990 polymorphism in the same gene is not associated with it.
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Bekenova N.B., Aitkaliev A.D., Sibagatova A.S., Alibekov S.R., Kassiyeva B.S. The role of SNCA gene polymorphisms in the development of cardiac autonomic neuropathy in individuals of Kazakh ethnicity // Nauka i Zdravookhranenie [Science & Healthcare]. 2023, (Vol.25) 4, pp. 59-66. doi 10.34689/SH.2023.25.4.007Related publications:
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