STUDY OF THE RELATIONSHIP BETWEEN TRIMETHYLAMINE N-OXIDE (TMAO) LEVELS AND CLINICAL PARAMETERS IN PATIENTS WITH ST-SEGMENT ELEVATION ACUTE CORONARY SYNDROME
Relevance: There are classic risk factors for atherosclerosis - gender, ethnicity, family history, diabetes mellitus, chronic kidney disease, obesity, hypertension, smoking. Research continues into traditional theories of atherosclerosis such as dyslipidemia, infection, and inflammation. Based on these theories, appropriate studies of blood lipids, C-reactive protein, and homocysteine are carried out in clinical practice. However, new factors are currently being identified in the pathogenesis of atherosclerosis - air pollution with microparticles, disruption of clonal hematopoiesis and changes in the proatherogenic metabolic biomarker trimethylamine N-oxide. Large studies have shown that TMAO may be a predictor of cardiovascular disease risk. TMAO is synthesized by intestinal microflora and studies are being conducted on these metabolic pathways and the factors influencing TMAO levels. In this regard, it is necessary to study the correlating relationship between the level of TMAO and a number of clinical indicators.
The aim: Based on clinical studies of patients with acute coronary syndrome with ST segment elevation, analyze possible predictors of changes in TMAO levels.
Materials and methods: The study was conducted as part of a larger body of research on the effects of dietary remodeling of the gut microbiota on oxidative status, trimethylamine oxide (TMAO) levels, and recurrent cardiovascular events after STEMI. The work hypothesized that there is a relationship between the resulting TMAO variable and a number of clinical indicators.
Results: To the greatest extent, changes in TMAO concentrations depend on the composition of the intestinal microbiome. Plasma TMAO levels have previously been shown to be determined by several factors, including consumption of its metabolic precursors, medications, and hepatic flavinmonooxygenase FMO activity.
Conclusion: The work analyzed the dependence of TMAO levels on 43 clinical indicators. It was revealed that there was a statistically significant correlation between the level of the coronary SYNTAX Score I scale, the presence of peptic ulcer disease and social status.
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SergazySh.D., Zhashkeyev A.K., Zhumadilov Zh.Sh. Study of the relationship between Trimethylamine N-oxide (TMAO) levels and clinical parameters in patients with ST-segment elevation acute coronary syndrome // Nauka i Zdravookhranenie [Science & Healthcare]. 2023, (Vol.25) 5, pp. 34-44. doi 10.34689/SH.2023.25.5.004Related publications:
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