THE ASSOCIATION OF RS11781551 AND RS6988985 WITH HYPERTENSION IN THE GROUP OF KAZAKH INDIVIDUALS
Background. Arterial hypertension (HT) is a leading risk factor for mortality and morbidity especially in the developing countries. Kazakhstan is not an exception, the first reason of death is cardiovascular diseases which are directly associated with high blood pressure. Among risk factors, the genetic ones are the least understood, so the aim of current study is to find association of some SNPs of eighth chromosome and HT in the group of Kazakh individuals.
Materials and Methods. A total of 606 Kazakh patients were recruited, 394 of them were diagnosed with HT, the remaining 212 were in the control group, i.e. did not have HT. The genotyping was performed using the Open Array technology. The SNPs and phenotype association assessment was taken in pairs of the HT- and HT+ groups, following the case-control design based on a GLM. The genotype and phenotype signs association was esteemed using 4 inheritance models: dominant, co-dominant, recessive, and log-additive inheritance models.
Results. It was found that the rs11781551 in codominant study model (OR 0.370 [0.157-0.871]) and in the dominant study model (OR 0.370 [0.157-0.871]) was associated with the presence of HT.
There is the significant association of rs6988985 and HT in studied population in codominant (for C/T genotype OR = 0.567 [0.336-0.956], for T/T genotype OR = 0.422 [0.224-0.795]), recessive (OR = 0.522 [0.316-0.861]) and log-additive models (OR = 0.648 [0.473-0.887]). These associations were found after the adjustments for gender and age, BMI, gender, glucose, total cholesterol, LDL, HDL and triglycerides.
Discussion. In the current analysis, it was found that two polymorphisms rs11781551 and rs6988985 significantly affected the presence of hypertension, regardless of age, gender, BMI, glucose level and lipid profile in the group of Kazakh individuals. These findings may have implications for the development of personalized approaches to the prevention and treatment of HT.
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Benberin V., Karabayeva R., Turgumbayeva Zh., Aitkaliyev A., Sibagatova A. The association of RS11781551 and RS6988985 with hypertension in the group of Kazakh individuals // Nauka i Zdravookhranenie [Science & Healthcare]. 2023, (Vol.25) 5, pp. 45-51. doi 10.34689/SH.2023.25.5.005Related publications:
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