ГЕОГРАФИЧЕСКОЕ РАСПРЕДЕЛЕНИЕ ГЕНОТИПОВ ВИРУСА ГЕПАТИТА В И СВЯЗЬ С КЛИНИЧЕСКИМИ ПРОЯВЛЕНИЯМИ ХРОНИЧЕСКОГО ВИРУСНОГО ГЕПАТИТА В: ОБЗОР ЛИТЕРАТУРЫ
Актуальность. Хронический вирусный гепатит Впредставляет собой глобальную проблему для общественного здравоохраненияво всем мире из-за высоких показателей инфицированности (более 250 млн. человек) исмертности (около 2 млн. человек). На прогрессирование и клинические исходы заболеваниявлияют множество факторов, начиная от биологических свойств вируса до генетических факторов. Цель. Анализ литературных источников, посвященных изучению распространенности генотипов и их влияния на клиническое течение хронического вирусного гепатита В. Стратегия поиска. Проведен поиск научных публикаций в поисковых системах PubMed, GoogleScholar, GoogleAcademia, в электронной научной библиотеке eLibrary.ru, CyberLeninka. Критерии включения: глубина поиска составила 15 лет (2004-2019); публикации на казахском, русском и английском языках; полнотекстовые эпидемиологические и клинические исследования. Критерии исключения: исследования, проведенные на животных, повторно встречающиеся публикации, исследования, связанные с изучением генотипов при вирусном гепатите С, с ответом на противирусную терапию, материалы конференций и клинические случаи. Результаты.Генотип D наиболее часто встречается и имеет повсеместное распространение. Генотипы А, В, С имеют характерное географическое распределение в Европе, странах Африканского контингента (генотип А) и Азии, в частности в Китае (генотип В) и Корее (генотип С). С благоприятным прогнозом чаще связан генотип В, в то время как неблагоприятное течение заболевания ассоциируется с С генотипом. Выводы.Таким образом, генотипы имеют характерное географическое расспределение и влияют на клиническое течение и исходы хронического вирусного гепатита В.
Айнур К. Кумарбекова1, Имдат М. Эфендиев1, Лидия А. Муковозова1 1 НАО «Медицинский университет Семей», г. Семей, Республика Казахстан
1. Азимова С.М., Дустов А. Особенности клинического течения хронического вирусного гепатита в Таджикистане // Клиническая медицина. 2012. № 8. С. 414-419. 2. Герасимова В. В., Левакова И. А., Бичурина М. А., Максимова Н. Р. Молекулярно-эпидемиологические особенности вирусного гепатита В // Инфекция и иммунитет. 2015. № 4. С 297-302. 3. Дуйсенова А. К., Курманова Г. М., Жусупова Р. Т., Байхожаева Р. Ж., Балгазин Б. Н. Профилактика неблагоприятных исходов вирусных гепатитов // Вестник Казахского Национального медицинского университета. 2013. № 4 (2). С. 276-281. 4. Дустов А. Особенности клинического течения хронического вирусного гепатита В в зависимости от его генотипов // Гастроэнтерология Санкт-Петербурга. 2011. №. 2-3. С. 414-419. 5. Елпаева Е.А., Порецкова Е.А., Писарева М.А., Ковеленов А.Ю., Аликян И.С., Гольбрайх Р.Б., Грудинин М.П., Эсауленко Е.В. Генотипическая характеристика вируса гепатита В у хронически инфицированных больных // Дальневосточный журнал инфекционной патологии. 2009. № 15. С. 55–58. 6. Елпаева Е. А., Писарева М. М., Никитина О. Е., Кижло С. Н., Грудинин М. П., Дуданова О. П. Роль мутантных форм вируса гепатита В в прогрессирующем течении хронического гепатита В. // Ученые записки Петрозаводского государственного университета. 2014. № 6 (143). С. 41-46. 7. Курманова Г.М., Масимова Э.А., Мухтарова З.Р., Алпарова А.Т., Молдаханова М.Д., Турениязова Н.А.. Серологическая диагностика вирусных гепатитов В, С и D // Mедицина. 2013. № 6. С 18-27. 8. Кочнева Г.В., Мануйлов В.А., Нетесова И.Г., Чуб Е.В., Баяндин Р.Б., Сиволобова Г.Ф., Гражданцева А.А., Нетесов С.В. Генотипы и субтипыизолятов вируса гепатита Вна территории Сибири // Проблемы особо опасных инфекций. 2011. № 3 (109). С. 31–35. 9. Мануйлов В.А., Осипова Л.П., Нетесова И.Г., Чуб Е.В., Безуглова Л.В., Нетёсов С.В. Распространенность различных генотипов и субтипов HBs-антигена вируса гепатита В группах коренного населения Сибири // Молекулярная генетика, микробиология и вирусология. 2015. № 1. С. 28-35. 10. Нерсесов А.В. Обзор исследований 2015-2017 годов по клинико-эпидемиологической характеристике болезней печени в Казахстане // Medicine. 2017. № 9 (183). С. 4-8. 11. Останкова Ю.В., Семенов А.В., Буркитбаев Ж.К., Савчук Т.Н., Тотолян А.А. Генетические варианты вируса гепатита B у первичных доноров в г. Астана, Казахстан // Инфекция и иммунитет. 2016. № 4. С. 359-366. 12. Слепцова С.С., Семенов С.И., Борисова Н.В., Петрова П.Г., Гоголев Н.М., Кылбанова Е.С. Основные факторы риска прогрессирования хронических вирусных гепатитов в Якутии // Вестник Северо-Восточного федерального университета им. М.К. Аммосова. 2017.№ 4 (9). С. 89-95. 13. Bae S.K., Yatsuhashi H., Hashimoto S., Motoyoshi Y., Ozawa E., Nagaoka S., Ito M.. Prediction of early HBeAg seroconversion by decreased titers of HBeAg in the serum combined with increased grades of lobular inflammation in the liver // Medical science monitor: international medical journal of experimental and clinical research. 2012. Vol. 18(12). Р. 698-705. 14. Bekku D., Arai M., Imazeki F., Yonemitsu Y., Kanda T., Fujiwara K., Yokosuka O. Long‐term follow‐up of patients with hepatitis B e antigen negative chronic hepatitis B // Journal of gastroenterology and hepatology. 2011. Vol. 26(1). P. 122-128. 15. Bruix J., Sherman M. Management of hepatocellular carcinoma: an update // Hepatology. 2011. Vol. 53. (3). P. 1020-1022. 16. Chan H.L., Hui A.Y., Wong M.L., Tse A.M., Hung L.C., Wong V.W., Sung J.J. Genotype C hepatitis B virus infection is associated with an increased risk of hepatocellular carcinoma // Gut. 2004. Vol. 53(10). P. 1494-1498. 17. Chen C.H., Hung C.H., Lee C.M., Hu T.H., Wang J.H., Wang J.C., Changchien C.S. Pre-S deletion and complex mutations of hepatitis B virus related to advanced liver disease in HBeAg-negative patients // Gastroenterology. 2007. Vol. 133(5). P. 1466-1474. 18. Chevaliez S., Rodriguez C., Pawlotsky J.M. New virologic tools for management of chronic hepatitis B and C // Gastroenterology. 2012. Vol. 142. (6). P. 1303-1313. 19. Chien-Jen Chen; Hwai-I Yang. Natural History of Chronic Hepatitis B // J Gastroenterology Hepatol. 2011. Vol. 26 (4). P. 628-638 20. Chu C.J., Keeffe E.B., Han S.H., Perrillo R.P., Min A.D., Soldevila-Pico C., Lok A.S. Hepatitis B virus genotypes in the United States: results of a nationwide study // Gastroenterology. 2004. Vol. 125(2). P. 444-451. 21. Depamede S.N., Wahyono A., Nagashima S., Takahashi M., Okamoto H. Analysis of the full‐length genomes of novel hepatitis B virus subgenotypes C11 and C12 in Papua, Indonesia // Journal of medical virology. 2011. Vol. 83(1). P.54-64. 22. Emekdaş G., Tezcan S., Aslan G., Serin M.S., Sezgin O., Ucbilek E., Döğen A. Determination of hepatitis B virus genotypes in chronic hepatitis B patients in Mersin province, Turkey // Mikrobiyolojibulteni. 2012. Vol. 46(3). P. 432-445. 23. Ezzikouri S., Pineau P., Benjelloun S. Hepatitis B virus in the Maghreb region: from epidemiology to prospective research // Liver International. 2013. Vol. 33. Vol. 6. P.811-819. 24. Fang Z.L., Sabin C.A., Dong B.Q., Wei S.C., Chen Q.Y., Fang K.X., Harrison T.J. The association of HBV core promoter double mutations (A1762T and G1764A) with viral load differs between HBeAg positive and anti-HBe positive individuals: a longitudinal analysis // Journal of hepatology. 2009. Vol. 50(2). P.273-280. 25. Fang Z.L., Sabin C.A., Dong B.Q., Wei S.C., Chen Q.Y., Fang K.X., Harrison T.J. Hepatitis B virus pre-S deletion mutations are a risk factor for hepatocellular carcinoma: a matched nested case–control study // The Journal of general virology. 2008. Vol. 89(11). P. 2882-2890. 26. Fattovich G., Bortolotti F., Donato F. Natural history of chronic hepatitis B: special emphasis on disease progression and prognostic factors // Journal of hepatology. 2008. Vol. 48. (2). P. 335-352. 27. Fattovich G., Rugge M., Brollo L., Pontisso P., Noventa F., Guido M., Realdi P. G. Clinical, virologic and histologic outcome following seroconversion from HBeAg to anti‐HBe in chronic hepatitis type B // Hepatology. 1986. Vol. 6(2). P.167-171. 28. Ferraro D., Urone N., Pizzillo P., Gussio M., Magliocco S., Cacopardo B., Di Stefano R. Phylogenetic analysis of isolates from new cases of HBV infection in Southern Italy // Infection, Genetics and Evolution. 2012. Vol. 12(8). P. 1591-1596. 29. Forbi J.C., Ben-Ayed Y., Xia G.L., Vaughan G., Drobeniuc J., Switzer W.M., Khudyakov Y.E. Disparate distribution of hepatitis B virus genotypes in four sub-Saharan African countries // Journal of Clinical Virology. 2013. Vol. 58(1). P. 59-66. 30. Grebely J., Dore G. J. What is killing people with hepatitis C virus infection? // Seminars in liver disease. 2011. Vol. 31. Vol. 04. P. 331-339. 31. Hadziyannis S. J. Natural history of chronic hepatitis B in Euro-Mediterranean and African countries // Journal of Hepatology. 2011. Vol. 55. (1). P. 183-191. 32. Hsieh Y.H., Su I.J., Wang H.C., Chang W.W., Lei H.Y., Lai M.D., Huang, W. Pre-S mutant surface antigens in chronic hepatitis B virus infection induce oxidative stress and DNA damage // Carcinogenesis. 2004. Vol. 25(10). P. 2023-2032. 33. Huy T.T., Ngoc T.T., Abe K.T. New complex recombinant genotype of hepatitis B virus identified in Vietnam // Journal of virology. 2008. Vol. 82. (11). P. 5657-5663. 34. Kao J.H. Molecular epidemiology of hepatitis B virus // The Korean journal of internal medicine. 2011. Vol. 26. (3). P. 255. 35. Kramvis A. Genotypes and genetic variability of hepatitis B virus // Intervirology. 2014. Vol. 57(3-4). P. 141-150. 36. Kurbanov F., Tanaka Y., Mizokami M. Geographical and genetic diversity of the human hepatitis B virus // Hepatology Research. 2010. Vol. 40. (1). P. 14-30. 37. Lin C.L., Kao J.H. Hepatitis B virus genotypes and variants // Cold Spring Harbor perspectives in medicine. 2015. Vol. 5. (5). P. 1-20. 38. Lin C.L., Kao J.H. The clinical implications of hepatitis B virus genotype: recent advances // Journal of gastroenterology and hepatology. 2011. Vol. 26. P. 123-130. 39. Lin C.L., Liu C.H., Chen W., Huang W.L., Chen P.J., Lai M.Y., Kao J.H. Association of pre‐S deletion mutant of hepatitis B virus with risk of hepatocellular carcinoma // Journal of gastroenterology and hepatology. 2007. Vol. 22(7). P.1098-1103. 40. Lindh M., Horal P., Dhillon A. P., Norkrans G. Hepatitis B virus DNA levels, precore mutations, genotypes and histological activity in chronic hepatitis B // Journal of viral hepatitis. 2004. Vol. 7(4). P. 258-267. 41. Liu C.J., Jeng Y.M., Chen C.L., Cheng H.R., Chen P.J., Chen T.C., Kao J.H. Hepatitis B virus basal core promoter mutation and DNA load correlate with expression of hepatitis B core antigen in patients with chronic hepatitis B // The Journal of infectious diseases. Vol. 199(5). P. 742-749. 42. Liu J., Lee M.H., Batrla-Utermann R., Jen C.L., Iloeje U.H., Lu S.N., Chen C.J. A predictive scoring system for the seroclearance of HBsAg in HBeAg-seronegative chronic hepatitis B patients with genotype B or C infection // Journal of hepatology. 2013. 58(5). P. 853-860. 43. Liu J., Yang H. I., Lee M.H., Lu S.N., Jen C.L., Batrla-Utermann R., Chen C.J. Spontaneous seroclearance of hepatitis B seromarkers and subsequent risk of hepatocellular carcinoma // Gut. 2014. Vol. 63(10). P. 1648-1657. 44. Livingston S.E., Simonetti J.P., Bulkow L.R., Homan C.E., Snowball M.M., Cagle H.H., McMahon B. J. Clearance of hepatitis B e antigen in patients with chronic hepatitis B and genotypes A, B, C, D, and F // Gastroenterology. 2007. Vol. 133(5). P.1452-1457. 45. Loomba R., Rivera M. M., Mc Burney R., Park Y., Haynes‐Williams V., Rehermann B., Heller T. The natural history of acute hepatitis C: clinical presentation, laboratory findings and treatment outcomes // Alimentary pharmacology & therapeutics. 2011. Vol. 33(5). P. 559-565. 46. Lunaček N.K., Poljak M., Matičič M. Distribution of hepatitis B virus genotypes in Europe and clinical implications: a review // Acta Dermatovenerologica Alpina, Pannonicaet Adriatica. 2018. Vol. 27(3).Р. 141-146. 47. Ma M., He M., Liao L., Guo Y., Yu D., Xiong Z., Liao P. Molecular epidemiology and population dynamics of hepatitis B virus in Dianjiang County, Chongqing, China // Archives of virology. Vol. 159(1). Р. 117-124. 48. Mc Mahon B.J. The influence of hepatitis B virus genotype and subgenotype on the natural history of chronic hepatitis B // Hepatology international. 2009. Vol. 3. (2). Р. 334-342. 49. Olinger C.M., Venard V., Njayou M., Oyefolu A.O. B., Maïga I., Kemp A.J., Muller C.P. Phylogenetic analysis of the precore/core gene of hepatitis B virus genotypes E and A in West Africa: new subtypes, mixed infections and recombinations // Journal of general virology. 2006. Vol.87(5). Р. 1163-1173. 50. Orito E., Mizokami M., Sakugawa H., Michitaka K., Ishikawa K., Ichida T. Japan HBV Genotype Research Group. A case-control study for clinical and molecular biological differences between hepatitis B viruses of genotypes B and C // Hepatology. 2004. Vol.33(1). Р. 218-223. 51. Ozaras R, Balkan II, Yemisen M, Tabak F. Epidemiology of HBV sub-genotypes D // Clinical researches hepatology gastroenterology. 2015. Vol.39. Р. 28–37. 52. Panduro A., Maldonado-Gonzalez M., Fierro N. A., Roman S. Distribution of HBV genotypes F and H in Mexico and Central America // Antiviral therapy. 2013. Vol. 18(3). P. 475-84. 53. Phung T.B., Alestig E., Nguyen T.L., Hannoun C., Lindh M. Genotype X/C recombinant (putative genotype I) of hepatitis B virus is rare in Hanoi, Vietnam—genotypes B4 and C1 predominate // Journal of medical virology. 2010. Vol. 82(8). P. 1327-1333. 54. Realdi G., Alberti A., Rugge M., Bortolotti F., Rigoli A. M., Tremolada F., Ruol A. Seroconversion from hepatitis B e antigen to anti-HBe in chronic hepatitis B virus infection // Gastroenterology. 1980. Vol. 79(2). P. 195-199. 55. Roman S., Panduro A. HBV endemicity in Mexico is associated with HBV genotypes H and G // World journal of gastroenterology. 2013. Vol. 19 (33). P. 5446-5453. 56. Roman S., Panduro A., Aguilar-Gutierrez Y., Maldonado M., Vazquez-VanDyck M., Martinez-Lopez E., Hernandez-Nazara Z. A low steady HBsAgseroprevalence is associated with a low incidence of HBV-related liver cirrhosis and hepatocellular carcinoma in Mexico: a systematic review // Hepatology international. 2009. Vol. 3(2). P. 343-355. 57. Sánchez-Tapias J. M., Costa J., Mas A., Bruguera M., Rodés J. Influence of hepatitis B virus genotype on the long-term outcome of chronic hepatitis B in western patients // Gastroenterology. 2004. Vol. 123(6). P. 1848-1856. 58. Sharma S., Sharma B., Singla B., Chawla Y. K., Chakraborti A., Saini N., Dhiman R. K. Clinical significance of genotypes and precore/basal core promoter mutations in HBV related chronic liver disease patients in North India // Digestive diseases and sciences. 2010. Vol. 55(3). P. 794-802. 59. Sunbul M. Hepatitis B virus genotypes: global distribution and clinical importance // World journal of gastroenterology. 2014. Vol. 20 (18). P. 5427-5434. 60. Tatematsu K., Tanaka Y., Kurbanov F., Sugauchi F., Mano S., Maeshiro T., Mizokami M. A genetic variant of hepatitis B virus divergent from known human and ape genotypes isolated from a Japanese patient and provisionally assigned to new genotype J // Journal of virology. 2009. Vol. 83(20). P. 10538-10547. 61. Thakur V., Guptan R. C., Kazim S. N., Malhotra V., Sarin S. K. Profile, spectrum and significance of HBV genotypes in chronic liver disease patients in the Indian subcontinent // Journal of gastroenterology and hepatology. 2004. Vol. 17(2). P. 165-170. 62. Tong S., Revill P. Overview of hepatitis B viral replication and genetic variability // Journal of hepatology. 2016. Vol. 64 (1). P. 4-16. 63. Uchida Y., Kouyama J. I., Naiki K., Sugawara K., Inao M., Nakayama N., Mochida S. Novel hepatitis B virus strain developing due to recombination between genotypes H and B strains isolated from a J apanese patient // Hepatology Research. 2014. Vol. 44(11). P. 1130-1141. 64. Vutien P., Trinh H.N., Nguyen K., Garcia R.T., Nguyen H.A., Levitt B.S., Garcia G. Precore and basal core promoter mutations in Asian American patients with hepatitis B e antigen‐positive chronic hepatitis B // Alimentary pharmacology & therapeutics. 2013. Vol. 37(4). P. 464-472. 65. Walter S.R., Thein H.H., Gidding H.F., Amin J., Law M.G., George J., Dore G.J. Risk factors for hepatocellular carcinoma in a cohort infected with hepatitis B or C // Journal of gastroenterology and hepatology. 2011. Vol. 26 (12). P. 1757-1764. 66. Wang Y., Lau S.H., Sham J. S. T., Wu M.C., Wang T., Guan X. Y. Characterization of HBV integrants in 14 hepatocellular carcinomas: association of truncated X gene and hepatocellular carcinogenesis // Oncogene. 2004. Vol. 23(1). P. 142-148. 67. Wong G.H., Chan H.Y., Yiu K.L., Lai J.Y., Chan V.K., Cheung K.C., Wong V.S. Meta‐analysis: the association of hepatitis B virus genotypes and hepatocellular carcinoma // Alimentary pharmacology & therapeutics. 2013. Vol. 37(5). P. 517-526. 68. Wu J.C., Huang Y.H., Chau G.Y., Su C.W., Lai C.R., Lee P.C., Lui W.Y. Risk factors for early and late recurrence in hepatitis B-related hepatocellular carcinoma // Journal of hepatology. 2009. Vol. 51(5). P. 890-897. 69. Yan L., Zhang H., Ma H., Liu D., Li W., Kang Y., Wang H. Deep sequencing of hepatitis B virus basal core promoter and precore mutants in HBeAg-positive chronic hepatitis B patients // Scientific reports. 2015. Vol. 5. P. 1-9. 70. Yang H.I., Yeh S.H., Chen P.J., Iloeje U.H., Jen C.L., Su J., Liaw Y.F. Associations between hepatitis B virus genotype and mutants and the risk of hepatocellular carcinoma // Journal of the National Cancer Institute. 2008. Vol. 100(16). P. 1134-1143. 71. Yin J., Zhang H., Li C., Gao C., He Y., Zhai Y., Cheng S. Role of hepatitis B virus genotype mixture, subgenotypes C2 and B2 on hepatocellular carcinoma: compared with chronic hepatitis B and asymptomatic carrier state in the same area // Carcinogenesis. 2008. Vol. 29(9). P. 1685-1691. 72. Yuen M. F., Sablon E., Yuan H.J., Wong D. K.H., Hui C.K., Wong B.C. Y., Lai C.L. Significance of hepatitis B genotype in acute exacerbation, HBeAg seroconversion, cirrhosis‐related complications, and hepatocellular carcinoma // Hepatology. 2004. Vol. 37(3). P. 562-567. References: 1. Azimova S.M., Dustov A. Osobennosti klinicheskogo techeniya khronicheskogo virusnogo gepatita v Tadzhikistane [Features of the clinical course of chronic viral hepatitis in Tajikistan]. Klinicheskaya meditsina [Clinical medicine]. 2012. No 8. pp.414-419. [in Russian]. 2. Gerasimova V.V., Levakova I.A., Bichurina M.A., Maksimova N.R. Molekulyarno-epidemiologicheskie osobennosti virusnogo gepatita B [Molecular epidemiological features of viral hepatitis B]. Infektsiya I immunitet [Infection and immunity]. 2015. No 4. pp.297-302. [in Russian]. 3. Dujsenova A.K., Kurmanova G.M., Zhusupova R.T., Bajhozhaeva R.ZH., Balgazin B.N. Profilaktika neblagopriyatnykh iskhodov virusnykh gepatitov [Prevention of adverse outcomes of viral hepatitis]. Vestnik Kazahskogo Nacional'nogo meditsinskogo universiteta [Bulletin of the Kazakh National Medical University]. 2013. No 4. pp. 276-281. [in Russian]. 4. Dustov A. Osobennosti klinicheskogo techeniya khronicheskogo virusnogo gepatita B v zavisimosti ot ego genotipov [Features of the clinical course of chronic viral hepatitis B, depending on its genotypes]. Gastroenterologiya Sankt-Peterburga [Gastroenterology of St. Petersburg]. 2011. No 2-3. pp. 414-419. [in Russian]. 5. Elpaeva Ye.A., Poretskova Ye.A., Pisareva M.A., Kovelenov A.Yu., Alikyan I.S., Golbraikh R.B., Grudinin M.P., Esaulenco Ye.V. Genotipicheskaya kharakteristika virusa gepatita B u khronicheskikh infitsirovannykh bolnykh [Genotypic characteristic of hepatitis B virus at chronically infected patients]. Dal’nevostochnyi zhurnal infektsionnoy patologii [Far East Journal of Infectious Pathology]. 2009. No 15. pp. 55- 58. [in Russian]. 6. Elpaeva E.A., Pisareva M.M., Nikitina O.E., Kizhlo S.N., Grudinin M.P., Dudanova O.P. Rol' mutantnykh form virusa gepatita V v progressiruyushchem techenii khronicheskogo gepatita B [The role of mutant forms of hepatitis B virus in the progressive course of chronic hepatitis B]. Uchenye zapiski Petrozavodskogo gosudarstvennogo universiteta [Scientific notes of Petrozavodsk State University]. 2014. No 6. pp. 41-46. [in Russian]. 7. Kurmanova G.M., Masimova E.A., Muhtarova Z.R., Alparova A.T., Moldahanova M.D., Tureniyazova N.A.. Serologicheskaya diagnostika virusnyh gepatitov В, Сi D [Serological diagnosis of viral hepatitis B, C and D]. Meditsina [Medicine]. 2013. No 6. pp.18-27. [in Russian]. 8. Kochneva G.V., Manujlov V.A., Netesova I.G., Chub E.V., Bayandin R.B., Sivolobova G.F., Grazhdanceva A.A., Netesov S.V. Genotipy i subtipy izolyatov virusa gepatita B na territorii Sibiri [Genotypes and subtypes of hepatitis B virus isolates in Siberia]. Problemy osobo opasnykh infektsii [Particularly dangerous infections]. 2011. No 3 (109). pp. 31-35. [in Russian]. 9. Manujlov V.A., Osipova L.P., Netesova I.G., Chub E.V., Bezuglova L.V., Netyosov S.V. Rasprostranennost' razlichnykh genotipov I subtipov HBs-antigena virusa gepatita V v gruppakh korennogo naseleniya Sibiri [The prevalence of various genotypes and subtypes of hepatitis B virus HBs-antigen in Siberian indigenous groups] Molekulyarnaya genetika, mikrobiologiya I virusologiya [Molecular Genetics, Microbiology and Virology]. 2015. No 1. pp. 28-35. [in Russian]. 10. Nersesov A.V. Obzor issledovanii 2015-2017 godov po kliniko-epidemiologicheskoi kharakteristike boleznei pecheni v Kazakhstane [Review of 2015-2017 studies on the clinical and epidemiological characteristics of liver diseases in Kazakhstan]. Meditsine [Medicine]. 2017. No 9 (183). pp. 4-8. [in Russian]. 11. Ostankova Yu.V., Semenov A.V., Burkitbaev Zh.K., Savchuk T.N., Totolyan A.A. Geneticheskie variant virusa gepatita B u pervichnykh donorov v g. Astana, Kazakhstan [Genetic variants of hepatitis B virus in primary donors in Astana, Kazakhstan]. Infektsiya iimmunitet [Infection and immunity]. 2016. No 4. pp. 359-366. [in Russian]. 12. Slepcova S.S., Semenov S.I., Borisova N.V., Petrova P.G., Gogolev N.M., Kylbanova E.S. Osnovnye factory riska progressirovaniya khronicheskikh virusnykh gepatitov v Yakutii [The main risk factors for the progression of chronic viral hepatitis in Yakutia]. Vestnik Severo-Vostochnogo federal'nogo universiteta im. M.K. Ammosova [Bulletin of the Northeast Federal University. M.K. Ammosova]. 2017.No 4 (9). pp. 89-95. [in Russian]. 13. Bae S.K., Yatsuhashi H., Hashimoto S., Motoyoshi Y., Ozawa E., Nagaoka S., Ito M.. Prediction of early HBeAgseroconversion by decreased titers of HBeAg in the serum combined with increased grades of lobular inflammation in the liver. Medical science monitor: international medical journal of experimental and clinical research. 2012. 18(12). pp. 698-705. 14. Bekku D., Arai M., Imazeki F., Yonemitsu Y., Kanda T., Fujiwara K., Yokosuka O. Long‐term follow‐up of patients with hepatitis B e antigen negative chronic hepatitis B. Journal of gastroenterology and hepatology. 2011. 26(1). pp. 122-128. 15. Bruix J., Sherman M. Management of hepatocellular carcinoma: an update. Hepatology. 2011. 53. (3).pp. 1020-1022. 16. Chan H.L., Hui A.Y., Wong M.L., Tse A.M., Hung L.C., Wong V.W., Sung J.J. Genotype C hepatitis B virus infection is associated with an increased risk of hepatocellular carcinoma. Gut. 2004. 53(10). pp. 1494-1498. 17. Chen C.H., Hung C.H., Lee C.M., Hu T.H., Wang J.H., Wang J.C., Changchien C.S. Pre-S deletion and complex mutations of hepatitis B virus related to advanced liver disease in HBeAg-negative patients. Gastroenterology. 2007. 133(5). pp. 1466-1474. 18. Chevaliez S., Rodriguez C., Pawlotsky J.M. New virologic tools for management of chronic hepatitis B and C. Gastroenterology. 2012. 142. (6).pp. 1303-1313. 19. Chien-Jen Chen; Hwai-I Yang. Natural History of Chronic Hepatitis B. J Gastroenterology Hepatol. 2011. 26 (4). pp. 628-638 20. Chu C.J., Keeffe E.B., Han S.H., Perrillo R.P., Min A.D., Soldevila-Pico C., Lok A.S. Hepatitis B virus genotypes in the United States: results of a nationwide study. Gastroenterology. 2004. 125(2). pp. 444-451. 21. Depamede S.N., Wahyono A., Nagashima S., Takahashi M., Okamoto H. Analysis of the full‐length genomes of novel hepatitis B virus subgenotypes C11 and C12 in Papua, Indonesia. Journal of medical virology. 2011. 83(1). pp.54-64. 22. Emekdaş G., Tezcan S., Aslan G., Serin M.S., Sezgin O., Ucbilek E., Döğen A. Determination of hepatitis B virus genotypes in chronic hepatitis B patients in Mersin province, Turkey. Mikrobiyolojibulteni. 2012. 46(3). pp. 432-445. 23. Ezzikouri S., Pineau P., Benjelloun S. Hepatitis B virus in the Maghreb region: from epidemiology to prospective research. Liver International. 2013. 6. pp. 811-819. 24. Fang Z.L., Sabin C.A., Dong B.Q., Wei S.C., Chen Q.Y., Fang K.X., Harrison T.J. The association of HBV core promoter double mutations (A1762T and G1764A) with viral load differs between HBeAg positive and anti-HBe positive individuals: a longitudinal analysis. Journal of hepatology. 2009. 50(2). pp.273-280. 25. Fang Z.L., Sabin C.A., Dong B.Q., Wei S.C., Chen Q.Y., Fang K.X., Harrison T.J. Hepatitis B virus pre-S deletion mutations are a risk factor for hepatocellular carcinoma: a matched nested case–control study. The Journal of general virology. 2008. 89 (11). pp. 2882-2890. 26. Fattovich G., Bortolotti F., Donato F. Natural history of chronic hepatitis B: special emphasis on disease progression and prognostic factors. Journal of hepatology. 2008. 48. (2). pp. 335-352. 27. Fattovich G., Rugge M., Brollo L., Pontisso P., Noventa F., Guido M., Realdi P. G. Clinical, virologic and histologic outcome following seroconversion from HBeAg to anti‐HBe in chronic hepatitis type B. Hepatology. 1986. 6(2). pp.167-171. 28. Ferraro D., Urone N., Pizzillo P., Gussio M., Magliocco S., Cacopardo B., Di Stefano R. Phylogenetic analysis of isolates from new cases of HBV infection in Southern Italy. Infection, Genetics and Evolution. 2012. 12(8). pp. 1591-1596. 29. Forbi J. C., Ben-Ayed Y., Xia G. L., Vaughan G., Drobeniuc J., Switzer W. M., Khudyakov Y. E. Disparate distribution of hepatitis B virus genotypes in four sub-Saharan African countries. Journal of Clinical Virology. 2013. 58(1). pp. 59-66. 30. Grebely J., Dore G.J. What is killing people with hepatitis C virus infection? Liver diseases. 2011. 31. Vol. 04. pp. 331-339. 31. Hadziyannis S.J. Natural history of chronic hepatitis B in Euro-Mediterranean and African countries. Journal of Hepatology. 2011. 55. (1). pp. 183-191. 32. Hsieh Y.H., Su I.J., Wang H.C., Chang W.W., Lei H.Y., Lai M.D., Huang W. Pre-S mutant surface antigens in chronic hepatitis B virus infection induce oxidative stress and DNA damage. Carcinogenesis. 2004. 25(10). pp. 2023-2032. 33. Huy T.T., Ngoc T.T., Abe K.T. New complex recombinant genotype of hepatitis B virus identified in Vietnam. Journal of virology. 2008. 82. (11). pp. 5657-5663. 34. Kao J.H. Molecular epidemiology of hepatitis B virus. The Korean journal of internal medicine. 2011. 26. (3). pp. 255. 35. Kramvis A. Genotypes and genetic variability of hepatitis B virus. Intervirology. 2014. 57(3-4). pp. 141-150. 36. Kurbanov F., Tanaka Y., Mizokami M. Geographical and genetic diversity of the human hepatitis B virus. Hepatology Research. 2010. 40. (1). pp. 14-30. 37. Lin C.L., Kao J.H. Hepatitis B virus genotypes and variants. Cold Spring Harbor perspectives in medicine. 2015. 5. (5). pp. 1-20. 38. Lin C.L., Kao J.H. The clinical implications of hepatitis B virus genotype: recent advances. Journal of gastroenterology and hepatology. 2011. 26. pp. 123-130. 39. Lin C.L., Liu C.H., Chen W., Huang W.L., Chen P.J., Lai M.Y., Kao J.H. Association of pre‐S deletion mutant of hepatitis B virus with risk of hepatocellular carcinoma. Journal of gastroenterology and hepatology. 2007. 22(7). pp.1098-1103. 40. Lindh M., Horal P., Dhillon A. P., Norkrans G. Hepatitis B virus DNA levels, precore mutations, genotypes and histological activity in chronic hepatitis B. Journal of viral hepatitis. 2004. 7(4). pp. 258-267. 41. Liu C.J., Jeng Y.M., Chen C.L., Cheng H.R., Chen P.J., Chen T.C., Kao J.H. Hepatitis B virus basal core promoter mutation and DNA load correlate with expression of hepatitis B core antigen in patients with chronic hepatitis B. The Journal of infectious diseases. 2009. 199(5). pp. 742-749. 42. Liu J., Lee M.H., Batrla-Utermann R., Jen C.L., Iloeje U.H., Lu S.N., Chen, C.J. A predictive scoring system for the seroclearance of HBsAg in HBeAg-seronegative chronic hepatitis B patients with genotype B or C infection. Journal of hepatology. 2013. 58(5). pp. 853-860. 43. Liu J., Yang H.I., Lee M.H., Lu S.N., Jen C.L., Batrla-Utermann R., Chen C.J. Spontaneous seroclearance of hepatitis B seromarkers and subsequent risk of hepatocellular carcinoma. Gut. 2014. 63(10). pp. 1648-1657. 44. Livingston S.E., Simonetti J.P., Bulkow L.R., Homan C.E., Snowball M.M., Cagle H.H., McMahon B.J. Clearance of hepatitis B e antigen in patients with chronic hepatitis B and genotypes A, B, C, D, and F. Gastroenterology. 2007.133(5). рр.1452-1457. 45. Loomba R., Rivera M.M., McBurney R., Park Y., Haynes‐Williams V., Rehermann B., Heller T. The natural history of acute hepatitis C: clinical presentation, laboratory findings and treatment outcomes. Alimentary pharmacology & therapeutics. 2011.33(5). рр. 559-565. 46. Lunaček N.K., Poljak M., Matičič M. Distribution of hepatitis B virus genotypes in Europe and clinical implications: a review. Acta Dermatovenerologica Alpina, Pannonicaet Adriatica. 2018. 27(3).рр. 141-146. 47. Ma M., He M., Liao L., Guo Y., Yu D., Xiong Z., Liao P. Molecular epidemiology and population dynamics of hepatitis B virus in Dianjiang County, Chongqing, China. Archives of virology. 159(1). рр. 117-124. 48. McMahon B.J. The influence of hepatitis B virus genotype and subgenotype on the natural history of chronic hepatitis B. Hepatology international. 2009. 3. (2).рр. 334-342. 49. Olinger C. M., Venard V., Njayou M., Oyefolu A.O. B., Maïga I., Kemp A.J., Muller C.P. Phylogenetic analysis of the precore/core gene of hepatitis B virus genotypes E and A in West Africa: new subtypes, mixed infections and recombinations. Journal of general virology. 2006. 87(5).рр. 1163-1173. 50. Orito E., Mizokami M., Sakugawa H., Michitaka K., Ishikawa K., Ichida T. Japan HBV Genotype Research Group. A case-control study for clinical and molecular biological differences between hepatitis B viruses of genotypes B and C. Hepatology.2004. 33(1).рр. 218-223. 51. Ozaras R., Balkan I.I., Yemisen M., Tabak F. Epidemiology of HBV sub-genotypes D. Clinical researches hepatology gastroenterology.2015. 39. рр. 28–37. 52. Panduro A., Maldonado-Gonzalez M., Fierro N.A., Roman S. Distribution of HBV genotypes F and H in Mexico and Central America. Antiviral therapy.2013. 18(3).рр. 475-84. 53. Phung T.B., Alestig E., Nguyen T.L., Hannoun C., Lindh M.Genotype X/C recombinant (putative genotype I) of hepatitis B virus is rare in Hanoi, Vietnam—genotypes B4 and C1 predominate. Journal of medical virology. 2010.82(8). рр. 1327-1333. 54. Realdi G., Alberti A., Rugge M., Bortolotti F., Rigoli A. M., Tremolada F., Ruol A. Seroconversion from hepatitis B e antigen to anti-HBe in chronic hepatitis B virus infection. Gastroenterology. 1980.79(2). рр. 195-199. 55. Roman S., Panduro A.HBV endemicity in Mexico is associated with HBV genotypes H and G. World journal of gastroenterology. 2013.19 (33). рр. 5446-5453. 56. Roman S., Panduro A., Aguilar-Gutierrez Y., Maldonado M., Vazquez-VanDyck M., Martinez-Lopez E., Hernandez-Nazara Z.A low steady HBsAgseroprevalence is associated with a low incidence of HBV-related liver cirrhosis and hepatocellular carcinoma in Mexico: a systematic review. Hepatology international. 2009.3(2). рр. 343-355. 57. Sánchez-Tapias J.M., Costa J., Mas A., Bruguera M., Rodés J. Influence of hepatitis B virus genotype on the long-term outcome of chronic hepatitis B in western patients. Gastroenterology. 2004.123(6). рр. 1848-1856. 58. Sharma S., Sharma B., Singla B., Chawla Y.K., Chakraborti A., Saini N., Dhiman R.K. Clinical significance of genotypes and precore/basal core promoter mutations in HBV related chronic liver disease patients in North India. Digestive diseases and sciences. 2010.55(3). рр. 794-802. 59. Sunbul M. Hepatitis B virus genotypes: global distribution and clinical importance. World journal of gastroenterology. 2014. 20 (18). рр. 5427-5434. 60. Tatematsu K., Tanaka Y., Kurbanov F., Sugauchi F., Mano S., Maeshiro T., Mizokami M. A genetic variant of hepatitis B virus divergent from known human and ape genotypes isolated from a Japanese patient and provisionally assigned to new genotype J. Journal of virology. 2009.83(20). P. 10538-10547. 61. Thakur V., Guptan R. C., Kazim S.N., Malhotra V., Sarin S.K. Profile, spectrum and significance of HBV genotypes in chronic liver disease patients in the Indian subcontinent. Journal of gastroenterology and hepatology. 2004.17(2). рр. 165-170. 62. Tong S., Revill P. Overview of hepatitis B viral replication and genetic variability. Journal of hepatology. 2016.64 (1). рр. 4-16. 63. Uchida Y., Kouyama J.I., Naiki K., Sugawara K., Inao M., Nakayama N., Mochida S. Novel hepatitis B virus strain developing due to recombination between genotypes H and B strains isolated from a J apanese patient. Hepatology Research. 2014. 44(11). рр. 1130-1141. 64. Vutien P., Trinh H.N., Nguyen K., Garcia R.T., Nguyen H.A., Levitt B.S., Garcia G. Precore and basal core promoter mutations in Asian American patients with hepatitis B e antigen‐positive chronic hepatitis B. Alimentary pharmacology & therapeutics. 2013.37(4). рр. 464-472. 65. Walter S.R., Thein H.H., Gidding H.F., Amin J., Law M.G., George J., Dore G.J. Risk factors for hepatocellular carcinoma in a cohort infected with hepatitis B or C. Journal of gastroenterology and hepatology. 2011. 26 (12). рр. 1757-1764. 66. Wang Y., Lau S.H., Sham J.S.T., Wu M.C., Wang T., Guan X.Y. Characterization of HBV integrants in 14 hepatocellular carcinomas: association of truncated X gene and hepatocellular carcinogenesis. Oncogene. 2004.23(1). рр. 142-148. 67. Wong G.H., Chan H.Y., Yiu K.L., Lai J.Y., Chan V.K., Cheung K.C., Wong V.S. Meta‐analysis: the association of hepatitis B virus genotypes and hepatocellular carcinoma. Alimentary pharmacology & therapeutics. 2013.37(5). рр. 517-526. 68. Wu J.C., Huang Y.H., Chau G.Y., Su C.W., Lai C.R., Lee P.C., Lui W.Y. Risk factors for early and late recurrence in hepatitis B-related hepatocellular carcinoma. Journal of hepatology. 2009.51(5). рр. 890-897. 69. Yan L., Zhang H., Ma H., Liu D., Li W., Kang Y., Wang H. Deep sequencing of hepatitis B virus basal core promoter and precore mutants in HBeAg-positive chronic hepatitis B patients. Scientific reports. 2015. 5. рр. 1-9. 70. Yang H.I., Yeh S.H., Chen P.J., Iloeje U.H., Jen C.L., Su J., Liaw Y. F.Associations between hepatitis B virus genotype and mutants and the risk of hepatocellular carcinoma. Journal of the National Cancer Institute. 2008.100(16). рр. 1134-1143. 71. Yin J., Zhang H., Li C., Gao C., He Y., Zhai Y., Cheng S.Role of hepatitis B virus genotype mixture, subgenotypes C2 and B2 on hepatocellular carcinoma: compared with chronic hepatitis B and asymptomatic carrier state in the same area. Carcinogenesis. 2008. 29(9). рр. 1685-1691. 72. Yuen M.F., Sablon E., Yuan H.J., Wong D.K.H., Hui C.K., Wong B.C.Y., Lai C.L. Significance of hepatitis B genotype in acute exacerbation, HBeAg seroconversion, cirrhosis‐related complications, and hepatocellular carcinoma. Hepatology. 2004. 37(3). рр. 562-567.
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Кумарбекова А.К., Эфендиев И.М., Муковозова Л.А. Географическое распределение генотипов вируса гепатита В и связь с клиническими проявлениями хронического вирусного гепатита В: обзор литературы // Наука и Здравоохранение. 2019. 6 (Т.21). С. 11-23.