МОЛЕКУЛЯРНЫЕ ПАТТЕРНЫ ПИЩЕВОЙ АЛЛЕРГИИ В ДЕТСКОМ ВОЗРАСТЕ: ОБЗОР ЛИТЕРАТУРЫ
Актуальность: на сегодняшний день молекулярная диагностика является инновационным подходом, используемым для характеристики молекулярных компонентов каждого аллергена, участвующего в специфическом IgE (sIgE) - опосредованном ответе. В клинической практике компонентная диагностика позволяет врачам повысить точность клинического диагноза, подобрать эффективную терапию и сделать прогноз заболевания. Цель: Анализ литературных данных, посвященных изучению распространенности и модели пищевой аллергии у детей различного возраста. Стратегия поиска: Проведен поиск научных публикаций в поисковых системах PubMed, Cochrane Library, GoogleScholar, GoogleAcademia, в электронной научной библиотеке eLibrary.ru, CyberLeninka. Критерии включения: публикации Казахстанских авторов, а также работы ученых ближнего и дальнего зарубежья; полнотекстовые эпидемиологические и клинические исследования. В связи с важностью раскрытия исторической последовательности развития специфической молекулярной аллергодиагностики, глубина поиска составила 10 лет (2010-2020). Исследование было осуществлено путем поиска ключевых слов: молекулярная аллергодиагностика, пищевая аллергия, мажорные пищевые аллергены, специфические IgE. Предпочтение отдавалось работам, имеющим дизайн высокого качества - когортные исследования, систематические обзоры, мета-анализ. В случае их отсутствия, учитывались результаты поперечных исследований. В анализ включены 56 работ. Результаты: молекулярная аллергологическая диагностика является важным шагом в повышении точности определения IgE-опосредованной сенсибилизации при пищевой аллергии. Возможность правильно идентифицировать и характеризовать отдельные аллергены на молекулярном уровне приводит к четкому пониманию механизмов сенсибилизации к пище. Выводы: Выявлены новые инсайты и тренды относительно процесса сенсибилизации, определены новые возможности и эффективность специфической иммунотерапии при использовании рекомбинантных аллергенов.
Кристина Г. Влашенюк1, Марина А. Моренко1, Сауле М. Жумамбаева1, Рафаил И. Розенсон1 1 НАО «Медицинский университет Астана», Кафедра детских болезней №1, г. Нур-Султан, Республика Казахстан.
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Comparison of food allergy prevalence among Chinese infants in Chongqing, 2009 versus 1999. Pediatr Int 2010. N 52. P. 820-824. 22. Iweala O.I., Choudhary S.K., Commins S.P. Food Allergy. Curr Gastroenterol Rep. 2018 N20 (5) P. 17. 23. Jackson K.D., Howie L.D., Akinbami L.J. Trends in allergic conditions among children: United States, 1997-2011. NCHS Data Brief. 2013. N 121. P. 1‐8. 24. Jakob T., Forstenlechner P., Matricardi P., Kleine-Tebbe J. Molecular allergy diagnostics using multiplex assays: methodological and practical considerations for use in research and clinical routine: Part 21 of the Series Molecular Allergology. Allergo J Int. 2015. N 24. P. 320-332. 25. Julie Wang., Jing Lin. et al. Correlation of IgE/IgG4 milk epitopes and affinity of milk-specific IgE antibodies with different phenotypes of clinical milk allergy. Allergy Clin Immunol. 2010. N 125 (3). P. 695–702. 26. Keet C.A., Savage J.H., Seopaul S., Peng R.D., Wood R.A., Matsui E.C. Temporal trends and racial/ethnic disparity in self-reported pediatric food allergy in the United States. Ann Allergy Asthma Immunol. 2014;112(3):222-229.e3. 27. Linhart B., Freidl R., Elisyutina O., Khaitov M., Karaulov A., Valenta R. Molecular Approaches for Diagnosis, Therapy and Prevention of Cow´s Milk Allergy. Nutrients. 2019. N. 11(7). P. 1492. 28. Longo G., Berti I., Burks A.W., Krauss B., Barbi E. IgE-mediated food allergy in children. Lancet. 2013. N 382(9905). P.1656‐1664. 29. Maryniak N.Z., Hansen E.B., Ballegaard A.R., Sancho A.I., Bøgh K.L. Comparison of the Allergenicity and Immunogenicity of Camel and Cow's Milk-A Study in Brown Norway Rats. Nutrients. 2018. N. 10 (12). P. 1903. 30. Matricardi P.M., Kleine-Tebbe J., Hoffmann H.J., et al. EAACI Molecular Allergology User's Guide. Pediatr Allergy Immunol. 2016. N 27 (Suppl 23). P. 1‐250. 31. Melioli G., Canonica G.W., Compalati E., Bonini S. The added value of allergen microarray technique to the management of poly-sensitized allergic patients. Curr. Opin. Allergy Clin. Immunol. 2012. N12. P. 434-439. 32. Moonesinghe H., Mackenzie H., Venter C., et al. Prevalence of fish and shellfish allergy: A systematic review. Ann Allergy Asthma Immunol. 2016. N117(3). P. 264‐272. 33. Muraro A., Werfel T., Hoffmann-Sommergruber K., et al. EAACI food allergy and anaphylaxis guidelines: diagnosis and management of food allergy. Allergy. 2014. N 69 (8). P. 1008‐1025. 34. Nurmatov U., Dhami S., Arasi S., et al. Allergen immunotherapy for IgE-mediated food allergy: a systematic review and meta-analysis. Allergy. 2017. N 72 (8). P. 1133‐1147. 35. Nwaru B.I., Hickstein L., Panesar S.S., et al. Prevalence of common food allergies in Europe: a systematic review and meta-analysis. Allergy. 2014. N 69 (8). P. 992‐1007. 36. Pekar J., Ret D., Untersmayr E. Stability of allergens. Mol Immunol. 2018;100:14‐20. 37. Pomés A., Davies J.M., Gadermaier G., et al. WHO/IUIS Allergen Nomenclature: Providing a common language. Mol Immunol. 2018. N. 100. P. 3-13. 38. Popescu F.D. Cross-reactivity between aeroallergens and food allergens. World J Methodol. 2015. N 5(2). P.31‐50. 39. Pree I., Valenta R. et al. Inhibition of CD23-dependent facilitated allergen binding to B cells following vaccination with genetically modified hypoallergenic Bet v 1 molecules. Clin Exp Allergy. 2010. N 40. P. 1346-1352. 40. Ricci G., Andreozzi L., Cipriani F., Giannetti A., Gallucci M., Caffarelli C. Wheat Allergy in Children: A Comprehensive Update. Medicina (Kaunas). 2019. N 55(7). P. 400. 41. Schocker F., Kull S., Schwager C., Behrends J., Jappe U. Individual Sensitization Pattern Recognition to Cow's Milk and Human Milk Differs for Various Clinical Manifestations of Milk Allergy. Nutrients. 2019. N 11(6). P. 1331. 42. Scott H.S. Food allergies. Medicine Allergology and Immunology. 2009. N 28. P. 211-219. 43. Sicherer S.H., Sampson H.A. Food allergy: A review and update on epidemiology, pathogenesis, diagnosis, prevention, and management. J Allergy Clin Immunol. 2018. N 141(1). P. 41‐58. 44. Siqueiros-Cendón T., Arévalo-Gallegos S., Iglesias-Figueroa B.F., García-Montoya I.A., Salazar-Martínez J., Rascón-Cruz Q. Immunomodulatory effects of lactoferrin. Acta Pharmacol Sin. 2014. N. 35. (5). P. 557-566. 45. Tan J.W., Joshi P. Egg allergy: an update. J. Paediatr. Child Health. 2014. N 50 (1). P. 11–50. 46. Tripodi S., Frediani T., Lucarelli S., Macri F. et al. Molecular profiles of IgE to Phleum pratense in children with grass pollen allergy: Implications for specific immunotherapy. J. Allergy Clin. Immunol. 2012. N 129. P. 834-839. 47. Tscheppe A., Breiteneder H. Recombinant Allergens in Structural Biology, Diagnosis, and Immunotherapy. Int Arch Allergy Immunol. 2017. № 172. (4). P. 187-202. 48. Umasunthar T., Leonardi-Bee J., Hodes M., et al. The incidence of food anaphylaxis in people with food allergies: a systematic review and meta-analysis. Clin Exp Allergy. 2013. N 43. P.1333-1341. 49. Urisu A., Kondo Y., Tsuge I. Hen's Egg Allergy. Chem Immunol Allergy. 2015. N. 101. P. 124-130. 50. Valenta R., Karaulov A., Niederberger V., et al. Molecular Aspects of Allergens and Allergy. Adv Immunol. 2018. N 138. P. 195-256. 51. Valenta R., Campana R., Focke-Tejkl M. Vaccine development for allergen-specific immunotherapy based on recombinant allergens and synthetic allergen peptides: Lessons from the past and novel mechanisms of action for the future. J Allergy Clin Immunol. 2016. N 137 (2). P. 351-357. 52. Valenta R., Lidholm J., Ferreira F. et al. From allergen genes to allergy vaccines. Annu Rev Immunol. 2010. N 28. P. 211-241. 53. van Zuuren E.J., Terreehorst I., Tupker R.A., Hiemstra P.S., Akkerdaas J.H. Anaphylaxis after consuming soy products in patients with birch pollinosis. Allergy. 2010. N 65(10). P. 1348‐1349. 54. Willits E.K., Park M.A., Hartz M.F., Schleck C.D., Weaver A.L., Joshi A.Y. Food allergy: a comprehensive population-based cohort study. Mayo Clin Proc. 2018. N 93. P. 1423-1430. 55. Zhernov Y., Curin M., Khaitov M., Karaulov A., Valenta R. Recombinant allergens for immunotherapy: state of the art. Curr Opin Allergy Clin Immunol. 2019. N 19(4). P. 402‐414. 56. Zijlstra W.T., Flinterman A.E., Soeters L., et al. Parental anxiety before and after food challenges in children with suspected peanut and hazelnut allergy. Pediatr Allergy Immunol. 2010. N 21(2). P. 439‐445.
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