МОЛЕКУЛЯРНЫЕ ПАТТЕРНЫ ПИЩЕВОЙ АЛЛЕРГИИ В ДЕТСКОМ ВОЗРАСТЕ: ОБЗОР ЛИТЕРАТУРЫ
Актуальность: на сегодняшний день молекулярная диагностика является инновационным подходом, используемым для характеристики молекулярных компонентов каждого аллергена, участвующего в специфическом IgE (sIgE) - опосредованном ответе. В клинической практике компонентная диагностика позволяет врачам повысить точность клинического диагноза, подобрать эффективную терапию и сделать прогноз заболевания.
Цель: Анализ литературных данных, посвященных изучению распространенности и модели пищевой аллергии у детей различного возраста.
Стратегия поиска: Проведен поиск научных публикаций в поисковых системах PubMed, Cochrane Library, GoogleScholar, GoogleAcademia, в электронной научной библиотеке eLibrary.ru, CyberLeninka. Критерии включения: публикации Казахстанских авторов, а также работы ученых ближнего и дальнего зарубежья; полнотекстовые эпидемиологические и клинические исследования. В связи с важностью раскрытия исторической последовательности развития специфической молекулярной аллергодиагностики, глубина поиска составила 10 лет (2010-2020). Исследование было осуществлено путем поиска ключевых слов: молекулярная аллергодиагностика, пищевая аллергия, мажорные пищевые аллергены, специфические IgE. Предпочтение отдавалось работам, имеющим дизайн высокого качества - когортные исследования, систематические обзоры, мета-анализ. В случае их отсутствия, учитывались результаты поперечных исследований. В анализ включены 56 работ.
Результаты: молекулярная аллергологическая диагностика является важным шагом в повышении точности определения IgE-опосредованной сенсибилизации при пищевой аллергии. Возможность правильно идентифицировать и характеризовать отдельные аллергены на молекулярном уровне приводит к четкому пониманию механизмов сенсибилизации к пище.
Выводы: Выявлены новые инсайты и тренды относительно процесса сенсибилизации, определены новые возможности и эффективность специфической иммунотерапии при использовании рекомбинантных аллергенов.
Кристина Г. Влашенюк1, Марина А. Моренко1,
Сауле М. Жумамбаева1, Рафаил И. Розенсон1
1 НАО «Медицинский университет Астана», Кафедра детских болезней №1,
г. Нур-Султан, Республика Казахстан.
1. Балаболкин И.И. Пищевая аллергия у детей: современные аспекты патогенеза и подходы к терапии и профилактике // Иммунопатология, аллергология, инфектология. 2013. №3. С. 36-46.
2. Испаева Ж.Б., Ревякина В.А., Сенцова Т.Б., с соавт. Взаимосвязь пищевой аллергии и атопического дерматита у детей // Вестник Казахского Национального медицинского университета, 2013. №. 4(1). С.183-187.
3. Лусс Л.В. Пищевые аллергены и пищевые добавки: роль в формировании пищевой аллергии и пищевой непереносимости // Эффективная фармакотерапия. 2014. N 33. С. 12-19.
4. Макарова С.Г., Намазова-Баранова Л.С., Вишнёва Е.А., Ерешко О.А., Гордеева И.Г. Гастроинтестинальная пищевая аллергия у детей // Вопросы современной педиатрии. 2017. 16 (3), C. 202-212.
5. Салтабаева У.Ш. Сравнительная оценка эффективности видов аллерген-специфической иммунотерапии при поллинозе: дис. … докт. философии: 6D110100. Астана, 2017. 211 С.
6. Baroglio C., Giuffrida M.G., Cantisani A., Napolitano L., Bertino E., Fabris C., Conti A. Evidence for a common epitope between bovine alpha-lactalbumin and beta-lactoglobulin // Biol Chem 2014. N 379. P. 1453-1456.
7. Blankestijn M.A., Remington B.C., Houben G.F., et al. Threshold Dose Distribution in Walnut Allergy // J Allergy Clin Immunol Pract. 2017. N5 (2). P. 376‐380.
8. Bloom K.A., Huang F.R., Bencharitiwong R., et al. Effect of heat treatment on milk and egg proteins allergenicity // Pediatr Allergy Immunol. 2014. N 25 (8). P. 740‐746.
9. Boyce J.A., Assa'ad A., Burks A.W., et al. Guidelines for the Diagnosis and Management of Food Allergy in the United States: summary of the NIAID-sponsored expert panel report // J Am Diet Assoc. 2011;111(1):17-27.
10. Bunyavanich S., Rifas-Shiman S.L., Platts-Mills T.A., et al. Peanut allergy prevalence among school-age children in a US cohort not selected for any disease // J Allergy Clin Immunol. 2014. N 134 (3). P. 753‐755.
11. Caubet J.C., Kondo Y., Urisu A., Nowak-Węgrzyn A. Molecular diagnosis of egg allergy // Curr Opin Allergy Clin Immunol. 2011. N 11(3). P. 210‐215.
12. Caubet J.C., Wang J. Current understanding of egg allergy // Pediatr Clin North Am. 2011. N. 58. (2). P. 427-xi.
13. Chang C., Lahti T., Tanaka T., Nickerson M.T. Egg proteins: fractionation, bioactive peptides and allergenicity // J Sci Food Agric. 2018. N 98. (15). P. 5547-5558.
14. Chipps B.E. Update in pediatric anaphylaxis: a systematic review // Clin Pediatr (Phila) 2013. N 6. P. 451–461
15. Chruszcz M., Kapingidza A.B., Dolamore C., Kowal K. A robust method for the estimation and visualization of IgE cross-reactivity likelihood between allergens belonging to the same protein family // PLoS One. 2018. N. 13. (11). P, e0208276.
16. Ebisawa M., Shibata R., Sato S., Borres M.P., Ito K. Clinical utility of IgE antibodies to ω-5 gliadin in the diagnosis of wheat allergy: a pediatric multicenter challenge study // Int Arch Allergy Immunol. 2012. N 158(1). P. 71‐76.
17. Ferreira F., Wolf M., Wallner M. Molecular approach to allergy diagnosis and therapy // Yonsei Med J. 2014. N 55(4) P. 839‐852.
18. García B.E., Lizaso M.T. Cross-reactivity Syndromes in Food Allergy // J Investig Allergol Clin Immunol 2011. N 21. Р. 162-170.
19. Glaumann S., Nopp A., Johansson S.G., Rudengren M., Borres M.P., Nilsson C. Basophil allergen threshold sensitivity, CD-sens, IgE-sensitization and DBPCFC in peanut-sensitized children // Allergy. 2012. N 67(2). P. 242‐247.
20. Hemmer W., Klug C., Swoboda I. Update on the bird-egg syndrome and genuine poultry meat allergy // Allergo J Int. 2016. N. 25. P. 68-75.
21. Hu Y., Chen J., Li H. Comparison of food allergy prevalence among Chinese infants in Chongqing, 2009 versus 1999 // Pediatr Int 2010. N 52. P. 820-824.
22. Iweala O.I., Choudhary S.K., Commins S.P. Food Allergy // Curr Gastroenterol Rep. 2018 N20 (5) P. 17.
23. Jackson K.D., Howie L.D., Akinbami L.J. Trends in allergic conditions among children: United States, 1997-2011 // NCHS Data Brief. 2013. N 121. P. 1‐8.
24. Jakob T., Forstenlechner P., Matricardi P., Kleine-Tebbe J. Molecular allergy diagnostics using multiplex assays: methodological and practical considerations for use in research and clinical routine: Part 21 of the Series Molecular Allergology // Allergo J Int. 2015. N 24. P. 320-332.
25. Julie Wang., Jing Lin. et al. Correlation of IgE/IgG4 milk epitopes and affinity of milk-specific IgE antibodies with different phenotypes of clinical milk allergy // Allergy Clin Immunol. 2010. N 125 (3). P. 695–702.
26. Keet C.A., Savage J.H., Seopaul S., Peng R.D., Wood R.A., Matsui E.C. Temporal trends and racial/ethnic disparity in self-reported pediatric food allergy in the United States // Ann Allergy Asthma Immunol. 2014;112(3):222-229.e3.
27. Linhart B., Freidl R., Elisyutina O., Khaitov M., Karaulov A., Valenta R. Molecular Approaches for Diagnosis, Therapy and Prevention of Cow´s Milk Allergy // Nutrients. 2019. N. 11(7). P. 1492.
28. Longo G., Berti I., Burks A.W., Krauss B., Barbi E. IgE-mediated food allergy in children // Lancet. 2013. N 382(9905). P.1656‐1664.
29. Maryniak N.Z., Hansen E.B., Ballegaard A.R., Sancho A.I., Bøgh K.L. Comparison of the Allergenicity and Immunogenicity of Camel and Cow's Milk-A Study in Brown Norway Rats // Nutrients. 2018. N. 10 (12). P. 1903.
30. Matricardi P.M., Kleine-Tebbe J., Hoffmann H.J., et al. EAACI Molecular Allergology User's Guide // Pediatr Allergy Immunol. 2016. N 27 (Suppl 23). P. 1‐250.
31. Melioli G., Canonica G.W., Compalati E., Bonini S. The added value of allergen microarray technique to the management of poly-sensitized allergic patients // Curr. Opin. Allergy Clin. Immunol. 2012. N12. P. 434-439.
32. Moonesinghe H., Mackenzie H., Venter C., et al. Prevalence of fish and shellfish allergy: A systematic review // Ann Allergy Asthma Immunol. 2016. N117(3). P. 264‐272.
33. Muraro A., Werfel T., Hoffmann-Sommergruber K., et al. EAACI food allergy and anaphylaxis guidelines: diagnosis and management of food allergy // Allergy. 2014. N 69 (8). P. 1008‐1025.
34. Nurmatov U., Dhami S., Arasi S., et al. Allergen immunotherapy for IgE-mediated food allergy: a systematic review and meta-analysis // Allergy. 2017. N 72 (8). P. 1133‐1147.
35. Nwaru B.I., Hickstein L., Panesar S.S., et al. Prevalence of common food allergies in Europe: a systematic review and meta-analysis // Allergy. 2014. N 69 (8). P. 992‐1007.
36. Pekar J., Ret D., Untersmayr E. Stability of allergens // Mol Immunol. 2018;100:14‐20.
37. Pomés A., Davies J.M., Gadermaier G., et al. WHO/IUIS Allergen Nomenclature: Providing a common language // Mol Immunol. 2018. N. 100. P. 3-13.
38. Popescu F.D. Cross-reactivity between aeroallergens and food allergens // World J Methodol. 2015. N 5(2). P.31‐50.
39. Pree I., Valenta R. et al. Inhibition of CD23-dependent facilitated allergen binding to B cells following vaccination with genetically modified hypoallergenic Bet v 1 molecules // Clin Exp Allergy. 2010. N 40. P. 1346-1352.
40. Ricci G., Andreozzi L., Cipriani F., Giannetti A., Gallucci M., Caffarelli C. Wheat Allergy in Children: A Comprehensive Update // Medicina (Kaunas). 2019. N 55(7). P. 400.
41. Schocker F., Kull S., Schwager C., Behrends J., Jappe U. Individual Sensitization Pattern Recognition to Cow's Milk and Human Milk Differs for Various Clinical Manifestations of Milk Allergy // Nutrients. 2019. N 11(6). P. 1331.
42. Scott H.S. Food allergies // Medicine Allergology and Immunology. 2009. N 28. P. 211-219.
43. Sicherer S.H., Sampson H.A. Food allergy: A review and update on epidemiology, pathogenesis, diagnosis, prevention, and management // J Allergy Clin Immunol. 2018. N 141(1). P. 41‐58.
44. Siqueiros-Cendón T., Arévalo-Gallegos S., Iglesias-Figueroa B.F., García-Montoya I.A., Salazar-Martínez J., Rascón-Cruz Q. Immunomodulatory effects of lactoferrin // Acta Pharmacol Sin. 2014. N. 35. (5). P. 557-566.
45. Tan J.W., Joshi P. Egg allergy: an update // J. Paediatr. Child Health. 2014. N 50 (1). P. 11–50.
46. Tripodi S., Frediani T., Lucarelli S., Macri F. et al. Molecular profiles of IgE to Phleum pratense in children with grass pollen allergy: Implications for specific immunotherapy // J. Allergy Clin. Immunol. 2012. N 129. P. 834-839.
47. Tscheppe A., Breiteneder H. Recombinant Allergens in Structural Biology, Diagnosis, and Immunotherapy // Int Arch Allergy Immunol. 2017. № 172. (4). P. 187-202.
48. Umasunthar T., Leonardi-Bee J., Hodes M., et al. The incidence of food anaphylaxis in people with food allergies: a systematic review and meta-analysis // Clin Exp Allergy 2013. N 43. P.1333-1341.
49. Urisu A., Kondo Y., Tsuge I. Hen's Egg Allergy. // Chem Immunol Allergy. 2015. N. 101. P. 124-130.
50. Valenta R., Karaulov A., Niederberger V., et al. Molecular Aspects of Allergens and Allergy // Adv Immunol. 2018. N 138. P. 195-256.
51. Valenta R., Campana R., Focke-Tejkl M. Vaccine development for allergen-specific immunotherapy based on recombinant allergens and synthetic allergen peptides: Lessons from the past and novel mechanisms of action for the future // J Allergy Clin Immunol. – 2016. N 137 (2). P. 351-357.
52. Valenta R., Lidholm J., Ferreira F. et al. From allergen genes to allergy vaccines // Annu Rev Immunol. 2010. N 28. P. 211-241.
53. van Zuuren E.J., Terreehorst I., Tupker R.A., Hiemstra P.S., Akkerdaas J.H. Anaphylaxis after consuming soy products in patients with birch pollinosis // Allergy. 2010. N 65(10). P. 1348‐1349.
54. Willits E.K., Park M.A., Hartz M.F., Schleck C.D., Weaver A.L., Joshi A.Y. Food allergy: a comprehensive population-based cohort study // Mayo Clin Proc. 2018. N 93. P. 1423-1430.
55. Zhernov Y., Curin M., Khaitov M., Karaulov A., Valenta R. Recombinant allergens for immunotherapy: state of the art // Curr Opin Allergy Clin Immunol. 2019. N 19(4). P. 402‐414.
56. Zijlstra W.T., Flinterman A.E., Soeters L., et al. Parental anxiety before and after food challenges in children with suspected peanut and hazelnut allergy // Pediatr Allergy Immunol. 2010. N 21(2). P. 439‐445.
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7. Blankestijn M.A., Remington B.C., Houben G.F., et al. Threshold Dose Distribution in Walnut Allergy. J Allergy Clin Immunol Pract. 2017. N5 (2). P. 376‐380.
8. Bloom K.A., Huang F.R., Bencharitiwong R., et al. Effect of heat treatment on milk and egg proteins allergenicity. Pediatr Allergy Immunol. 2014. N 25 (8). P. 740‐746.
9. Boyce J.A., Assa'ad A., Burks A.W., et al. Guidelines for the Diagnosis and Management of Food Allergy in the United States: summary of the NIAID-sponsored expert panel report. J Am Diet Assoc. 2011;111(1):17-27.
10. Bunyavanich S., Rifas-Shiman S.L., Platts-Mills T.A., et al. Peanut allergy prevalence among school-age children in a US cohort not selected for any disease. J Allergy Clin Immunol. 2014. N 134 (3). P. 753‐755.
11. Caubet J.C., Kondo Y., Urisu A., Nowak-Węgrzyn A. Molecular diagnosis of egg allergy. Curr Opin Allergy Clin Immunol. 2011. N 11(3). P. 210‐215.
12. Caubet J.C., Wang J. Current understanding of egg allergy. Pediatr Clin North Am. 2011. N. 58. (2). P. 427-xi.
13. Chang C., Lahti T., Tanaka T., Nickerson M.T. Egg proteins: fractionation, bioactive peptides and allergenicity. J Sci Food Agric. 2018. N 98. (15). P. 5547-5558.
14. Chipps B.E. Update in pediatric anaphylaxis: a systematic review. Clin Pediatr (Phila) 2013. N 6. P. 451–461
15. Chruszcz M., Kapingidza A.B., Dolamore C., Kowal K. A robust method for the estimation and visualization of IgE cross-reactivity likelihood between allergens belonging to the same protein family. PLoS One. 2018. N. 13. (11). P, e0208276.
16. Ebisawa M., Shibata R., Sato S., Borres M.P., Ito K. Clinical utility of IgE antibodies to ω-5 gliadin in the diagnosis of wheat allergy: a pediatric multicenter challenge study. Int Arch Allergy Immunol. 2012. N 158(1). P. 71‐76.
17. Ferreira F., Wolf M., Wallner M. Molecular approach to allergy diagnosis and therapy. Yonsei Med J. 2014. N 55(4) P. 839‐852.
18. García B.E., Lizaso M.T. Cross-reactivity Syndromes in Food Allergy. J Investig Allergol Clin Immunol 2011. N 21. Р. 162-170.
19. Glaumann S., Nopp A., Johansson S.G., Rudengren M., Borres M.P., Nilsson C. Basophil allergen threshold sensitivity, CD-sens, IgE-sensitization and DBPCFC in peanut-sensitized children. Allergy. 2012. N 67(2). P. 242‐247.
20. Hemmer W., Klug C., Swoboda I. Update on the bird-egg syndrome and genuine poultry meat allergy. Allergo J Int. 2016. N. 25. P. 68-75.
21. Hu Y., Chen J., Li H. Comparison of food allergy prevalence among Chinese infants in Chongqing, 2009 versus 1999. Pediatr Int 2010. N 52. P. 820-824.
22. Iweala O.I., Choudhary S.K., Commins S.P. Food Allergy. Curr Gastroenterol Rep. 2018 N20 (5) P. 17.
23. Jackson K.D., Howie L.D., Akinbami L.J. Trends in allergic conditions among children: United States, 1997-2011. NCHS Data Brief. 2013. N 121. P. 1‐8.
24. Jakob T., Forstenlechner P., Matricardi P., Kleine-Tebbe J. Molecular allergy diagnostics using multiplex assays: methodological and practical considerations for use in research and clinical routine: Part 21 of the Series Molecular Allergology. Allergo J Int. 2015. N 24. P. 320-332.
25. Julie Wang., Jing Lin. et al. Correlation of IgE/IgG4 milk epitopes and affinity of milk-specific IgE antibodies with different phenotypes of clinical milk allergy. Allergy Clin Immunol. 2010. N 125 (3). P. 695–702.
26. Keet C.A., Savage J.H., Seopaul S., Peng R.D., Wood R.A., Matsui E.C. Temporal trends and racial/ethnic disparity in self-reported pediatric food allergy in the United States. Ann Allergy Asthma Immunol. 2014;112(3):222-229.e3.
27. Linhart B., Freidl R., Elisyutina O., Khaitov M., Karaulov A., Valenta R. Molecular Approaches for Diagnosis, Therapy and Prevention of Cow´s Milk Allergy. Nutrients. 2019. N. 11(7). P. 1492.
28. Longo G., Berti I., Burks A.W., Krauss B., Barbi E. IgE-mediated food allergy in children. Lancet. 2013. N 382(9905). P.1656‐1664.
29. Maryniak N.Z., Hansen E.B., Ballegaard A.R., Sancho A.I., Bøgh K.L. Comparison of the Allergenicity and Immunogenicity of Camel and Cow's Milk-A Study in Brown Norway Rats. Nutrients. 2018. N. 10 (12). P. 1903.
30. Matricardi P.M., Kleine-Tebbe J., Hoffmann H.J., et al. EAACI Molecular Allergology User's Guide. Pediatr Allergy Immunol. 2016. N 27 (Suppl 23). P. 1‐250.
31. Melioli G., Canonica G.W., Compalati E., Bonini S. The added value of allergen microarray technique to the management of poly-sensitized allergic patients. Curr. Opin. Allergy Clin. Immunol. 2012. N12. P. 434-439.
32. Moonesinghe H., Mackenzie H., Venter C., et al. Prevalence of fish and shellfish allergy: A systematic review. Ann Allergy Asthma Immunol. 2016. N117(3). P. 264‐272.
33. Muraro A., Werfel T., Hoffmann-Sommergruber K., et al. EAACI food allergy and anaphylaxis guidelines: diagnosis and management of food allergy. Allergy. 2014. N 69 (8). P. 1008‐1025.
34. Nurmatov U., Dhami S., Arasi S., et al. Allergen immunotherapy for IgE-mediated food allergy: a systematic review and meta-analysis. Allergy. 2017. N 72 (8). P. 1133‐1147.
35. Nwaru B.I., Hickstein L., Panesar S.S., et al. Prevalence of common food allergies in Europe: a systematic review and meta-analysis. Allergy. 2014. N 69 (8). P. 992‐1007.
36. Pekar J., Ret D., Untersmayr E. Stability of allergens. Mol Immunol. 2018;100:14‐20.
37. Pomés A., Davies J.M., Gadermaier G., et al. WHO/IUIS Allergen Nomenclature: Providing a common language. Mol Immunol. 2018. N. 100. P. 3-13.
38. Popescu F.D. Cross-reactivity between aeroallergens and food allergens. World J Methodol. 2015. N 5(2). P.31‐50.
39. Pree I., Valenta R. et al. Inhibition of CD23-dependent facilitated allergen binding to B cells following vaccination with genetically modified hypoallergenic Bet v 1 molecules. Clin Exp Allergy. 2010. N 40. P. 1346-1352.
40. Ricci G., Andreozzi L., Cipriani F., Giannetti A., Gallucci M., Caffarelli C. Wheat Allergy in Children: A Comprehensive Update. Medicina (Kaunas). 2019. N 55(7). P. 400.
41. Schocker F., Kull S., Schwager C., Behrends J., Jappe U. Individual Sensitization Pattern Recognition to Cow's Milk and Human Milk Differs for Various Clinical Manifestations of Milk Allergy. Nutrients. 2019. N 11(6). P. 1331.
42. Scott H.S. Food allergies. Medicine Allergology and Immunology. 2009. N 28. P. 211-219.
43. Sicherer S.H., Sampson H.A. Food allergy: A review and update on epidemiology, pathogenesis, diagnosis, prevention, and management. J Allergy Clin Immunol. 2018. N 141(1). P. 41‐58.
44. Siqueiros-Cendón T., Arévalo-Gallegos S., Iglesias-Figueroa B.F., García-Montoya I.A., Salazar-Martínez J., Rascón-Cruz Q. Immunomodulatory effects of lactoferrin. Acta Pharmacol Sin. 2014. N. 35. (5). P. 557-566.
45. Tan J.W., Joshi P. Egg allergy: an update. J. Paediatr. Child Health. 2014. N 50 (1). P. 11–50.
46. Tripodi S., Frediani T., Lucarelli S., Macri F. et al. Molecular profiles of IgE to Phleum pratense in children with grass pollen allergy: Implications for specific immunotherapy. J. Allergy Clin. Immunol. 2012. N 129. P. 834-839.
47. Tscheppe A., Breiteneder H. Recombinant Allergens in Structural Biology, Diagnosis, and Immunotherapy. Int Arch Allergy Immunol. 2017. № 172. (4). P. 187-202.
48. Umasunthar T., Leonardi-Bee J., Hodes M., et al. The incidence of food anaphylaxis in people with food allergies: a systematic review and meta-analysis. Clin Exp Allergy. 2013. N 43. P.1333-1341.
49. Urisu A., Kondo Y., Tsuge I. Hen's Egg Allergy. Chem Immunol Allergy. 2015. N. 101. P. 124-130.
50. Valenta R., Karaulov A., Niederberger V., et al. Molecular Aspects of Allergens and Allergy. Adv Immunol. 2018. N 138. P. 195-256.
51. Valenta R., Campana R., Focke-Tejkl M. Vaccine development for allergen-specific immunotherapy based on recombinant allergens and synthetic allergen peptides: Lessons from the past and novel mechanisms of action for the future. J Allergy Clin Immunol. 2016. N 137 (2). P. 351-357.
52. Valenta R., Lidholm J., Ferreira F. et al. From allergen genes to allergy vaccines. Annu Rev Immunol. 2010. N 28. P. 211-241.
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Влашенюк К.Г., Моренко М.А., Жумамбаева С.М., Розенсон Р.И. Молекулярные паттерны пищевой аллергии в детском возрасте: обзор литературы // Наука и Здравоохранение. 2020. 4 (Т.22). С. 49-59. doi:10.34689/SH.2020.22.4.005Похожие публикации:
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