РОЛЬ ПОЛИМОРФИЗМОВ ГЕНОВ ЦИТОКИНОВ ПРИ БАКТЕРИАЛЬНЫХ ИНФЕКЦИЯХ, ВКЛЮЧАЯ БРУЦЕЛЛЕЗ. ОБЗОР ЛИТЕРАТУРЫ
Актуальность. Проведенными к настоящему времени исследованиями показано наличие ассоциаций полиморфизмов генов ряда цитокинов с предрасположенностью или резистентностью к развитию многих инфекционных заболеваний.
Цель. Анализ литературных источников по ассоциации полиморфизмов генов цитокинов с инфекционными заболеваниями бактериального генеза, в частности, с бруцеллезом.
Стратегия поиска. Проведен поиск научных публикаций в поисковых системах PubMed, GoogleScholar, GoogleAcademia, в электронной научной библиотеке eLibrary.ru, глубиной 10 лет. Критерии включения: глубина поиска составила 10 лет (2008-2018); публикации на казахском, русском и английском языках; полнотекстовые эпидемиологические и клинические исследования. Критерии исключения: публикации с исследованиями, проведенными на животных, повторно встречающиеся публикации, материалы конференций и клинические случаи.
Результаты. Анализ литературных источников показал, что с такими бактериальными инфекциями как туберкулез, рожа и бруцеллез наиболее часто ассоциируются полиморфизмы генов следующих цитокинов: ФНО-α, ИЛ-10, ИЛ-1β, ИЛ-17А, ИЛ-6. Результаты анализа также показали, что одни и те же полиморфизмы у разных этнических групп могут быть связаны как с предрасположенностью, так и с резистентностью. С бруцеллезом чаще были связаны полиморфизмы генов ИЛ-6, ИЛ-10 и ИЛ-17.
Выводы. Таким образом, подобные исследования необходимо проводить в определенной популяции людей одной национальности.
Лидия А. Муковозова1,
Назира Б. Бекенова1, http://orcid.org/0000-0002-3312-3299
Алма З. Токаева1, Ербол М. Смаил1
1 НАО «Медицинский университет Семей», г. Семей, Республика Казахстан
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30. Nadel S., Newport M.J., Booy R., Levin M. Variation in the tumor necrosis factor-α gene promoter region may be associated with death from meningococcal disease // Journal of Infectious Diseases. 1996. N 174(4). Р. 878-880.
31. Ocejo-Vinyals J., de Mateo E., Hoz M. The IL-17 G-152A single nucleotide polymorphism is associated with pulmonary tuberculosis in northern Spain // Cytokine. 2013. N 1. Р.58–61.
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33. Prieto-Pérez R., Cabaleiro T., Dauden E., Abad-Santos F. Gene polymorphisms that can predict response to anti-TNF therapy in patients with psoriasis and related autoimmune diseases // The pharmacogenomics journal. 2013. N13(4). 297-305.
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38. Shen L., Zhang H., Yan T., Zhou G., Liu R. Association between interleukin 17A polymorphisms and susceptibility to rheumatoid arthritis in a Chinese population // Gene.2015. N1. Р.18-22.
39. Stappers M., Thys Y., Oosting M., Plantinga T., Ioana M., Reimnitz P., Mouton J., Netea M., Joosten L.. Polymorphisms in cytokine genes IL6, TNF, IL10, IL17A and IFNG influence susceptibility to complicated skin and skin structure infections // European Journal of Clinical Microbiology & Infectious Diseases. 2014. N 33(12). P 2267-2274.
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41. Tunçbilek S. Relationship between cytokine gene polymorphisms and chronic hepatitis B virus infection // World journal of gastroenterology: WJG. 2014. N 20. Р. 6226-6235.
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12. Bogunia-Kubik K., Świerkot J., Malak A., Wysoczańska B., Nowak B., Białowąs K., Wiland P. IL-17A, IL-17F and IL-23R gene polymorphisms in Polish patients with rheumatoid arthritis. Archiv umimmunologi et therapy experimentalis. 2015. 3. pp.215-221.
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15. Budak F., Göral G., Heper Y., Yılmaz E., Aymak F., Baştürk B., Oral H. B. IL-10 and IL-6 gene polymorphisms as potential host susceptibility factors in Brucellosis. Cytokine. 2008. 38(1). pp. 32-36.
16. Ceylan E., Karkucak M., Coban H., Karadag M., Yakut T. Evaluation of TNF-alpha gene (G308A) and MBL2 gene codon 54 polymorphisms in Turkish patients with tuberculosis. Journal of infection and public health. 10(6). pp. 774-777.
17. Eskandari‐Nasab E., Moghadampour M., Sepanji-Nia A. TNF-α -238, -308, -863 Polymorphisms and Brucellosis Infection. Human Immunology. 2016. 77(1). pp.121-125.
18. Eskandari‐Nasab E., Moghadampour M., Asadi‐Saghandi A., Kharazi‐Nejad E., Rezaeifar A., Pourmasoumi H. Levels of interleukin‐(IL)‐12p40 are markedly increased in brucellosis among patients with specific IL‐12B genotypes. Scandinavian journal of immunology. 2013. 78(1). pp. 85-91.
19. Gunal O., Yigit S., Yalcın A.D., Celik B., Barut S., Demir O., Sezer O.The IL4-VNTR P1 allele, IL4-VNTR P2P2 genotype and IL4-VNTR_IL6-174CG P2P1-GG genotype are susceptable with a increased risk in Brucelosis. Japanese journal of infectious diseases. 2017. 70 (1).pp. 61-64.
20. Haukim N., Bidwell J.L., Smith A.J., Keen L.J., Gallagher G., Kimberly R., Huizinga T., McDermott M.F., Oksenberg J., McNicholl J., Pociot F., Hardt C., DAlfonso S. Cytokine gene polymorphism in human disease: on-line databases, supplement 2. Genes and immunity. 2002. 6. pp. 313-330.
21. Hu Y., Wu L., Li D., Zhao Q., Zhang W., Xu B. Association between cytokine gene polymorphisms and tuberculosis in a Chinese population in Shanghai: a case–control study. BMC immunology. 2015. 16(1). pp. 1-10.
22. Joshi L., Ponnana M., Sivangala R., Chelluri L.K., Nallari P., Penmetsa S., Valluri V., Gaddam S. Evaluation of TNF-α, IL-10 and IL-6 cytokine production and their correlation with genotype variants amongst tuberculosis patients and their household contacts. PloS one. 2015. 10(9). pp.1-15.
23. Karaoglan I., Pehlivan S., Namiduru M., Pehlivan M., Kilinçarslan C., Balkan Y., Baydar I. TNF-alpha, TGF-beta, IL-10, IL-6 and IFN-gamma gene polymorphisms as risk factors for brucellosis. New Microbiology. 2009. 32 (2). pp. 173-8.
24. Karaoglan I., Pehlivan S., Namiduru M., Pehlivan M., Kilinçarslan C., Balkan Y., Baydar I.TNF-alpha, TGF-beta, IL-10, IL-6 and IFN-gamma gene polymorphisms as risk factors for brucellosis. New Microbiology. 2009.32 (2). pp. 173-8.
25. Kazemi S., Saidijam M., Hashemi S. H., Karami M., Vaisi-Raygani A., Alikhani M.Y. Analysis of IL-10 and IL-6 gene polymorphisms and their serum levels in patients with brucellosis: a case control study. Immunological investigations. 2016. 45(2). pp. 107-115.
26. McGuire W., Hill A.V., Allsopp C.E., Greenwood B.M., Kwiatkowski D. Variation in the TNF-α promoter region associated with susceptibility to cerebral malaria. Nature. 1994.371(6497). pp. 508-511.
27. Meenakshi P., Ramya S, Shruthi T, Lavanya J, Mohammed H.H., Vijayalakshmi V, Sumanlatha G. Association of IL‐1β+ 3954 C/T and IL‐10‐1082 G/A Cytokine Gene Polymorphisms with Susceptibility to Tuberculosis. Scandinavian journal of immunology. 2013. 78(1). pp. 92-97.
28. Mira J.P., Cariou A., Grall F., Delclaux C., Losser M.R., Heshmati F., Cheval C., Monchi M., Teboul J.L., Riché F., Leleu G., Arbibe L., Mignon A., Delpech M., Dhainaut J.F. Association of TNF2, a TNF-α promoter polymorphism, with septic shock susceptibility and mortality: a multicenter study. Jama. 1999. 282(6). pp. 561-568.
29. Mosaad Y.M., Soliman O.E., Tawhid Z.E., Sherif D.M. Interferon‐gamma+ 874 T/A and Interleukin‐10‐1082 A/G Single nucleotide Polymorphism in Egyptian Children with Tuberculosis. Scandinavian journal of immunology. 2010. 72(4). pp. 358-364.
30. Nadel S., Newport M.J., Booy R., Levin M. Variation in the tumor necrosis factor-α gene promoter region may be associated with death from meningococcal disease. Journal of Infectious Diseases. 1996. 174(4). pp. 878-880.
31. Ocejo-Vinyals J., de Mateo E., Hoz M. The IL-17 G-152A single nucleotide polymorphism is associated with pulmonary tuberculosis in northern Spain. Cytokine. 2013.1. pp.58–61.
32. Pacheco A.G., Moraes M.O. Genetic polymorphisms of infectious diseases in case-control studies. Disease markers. 2009. 27. pp. 173-186.
33. Prieto-Pérez R., Cabaleiro T., Dauden E., Abad-Santos F. Gene polymorphisms that can predict response to anti-TNF therapy in patients with psoriasis and related autoimmune diseases. The pharmacogenomics journal. 2013. 13(4). pp. 297-305.
34. Rasouli M., Kalani M., Moravej A., Kiany S. Interleukin-18 single nucleotide polymorphisms contribute to the susceptibility to brucellosis in Iranian patients. Cytokine. 2011. 54 (3). pp. 272-276.
35. Rasouli M., Kiany S., Behbin M. Interleukin-10 gene polymorphisms and susceptibility to brucellosis in Iranian patients. Iranian journal of immunology. 2008. 5 (2). pp. 131-135.
36. Rasouli M., Kiany S. Association of interferon-gamma and interleukin-4 gene polymorphisms with susceptibility to brucellosis in Iranian patients. Cytokine. 2008. 38 (1). pp. 49-53.
37. Rasouli M., Asaei S., Kalani M., Kiany S., Moravej A. Interleukin-17A genetic variants can confer resistance to brucellosis in Iranian population. Cytokine. 2013. 61(1). pp. 297-303.
38. Shen L., Zhang H., Yan T., Zhou G., Liu R. Association between interleukin 17A polymorphisms and susceptibility to rheumatoid arthritis in a Chinese population. Gene. 2015. 1. pp.18-22.
39. Stappers M., Thys Y., Oosting M., Plantinga T., Ioana M., Reimnitz P., Mouton J., Netea M., Joosten L. Polymorphisms in cytokine genes IL6, TNF, IL10, IL17A and IFNG influence susceptibility to complicated skin and skin structure infections. European Journal of Clinical Microbiology & Infectious Diseases. 2014. 33(12). pp. 2267-2274.
40. Tarhuni A., Guyot E., Rufat P., Sutton A., Bourcier V., Grando V., Moreau R.Impact of cytokine gene variants on the prediction and prognosis of hepatocellular carcinoma in patients with cirrhosis. Journal of hepatology. 2014. 2. pp. 342-350.
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Муковозова Л.А., Бекенова Н.Б., Токаева А.З., Смаил Е.М. Роль полиморфизмов генов цитокинов при бактериальных инфекциях, включая бруцеллез. Обзор литературы // Наука и Здравоохранение. 2020. 5 (Т.22). С.47-56. doi:10.34689/SH.2020.22.5.004Похожие публикации:
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