Relevance: One of the important topical problems in the neonatal period with intranatal fetal hypoxia is hypoxic-ischemic brain damage in newborns. Timely adequate hardware therapeutic hypothermia has a positive neuroprotective effect, and its positive effects exceed its possible complications. In our case, in the early neonatal period, we were able to quickly stabilize the Blood gases (pCO2, BE, pH, lactate level), and also achieved a reduction in the duration of stay on the ventilator, thereby reducing the duration of hospitalization in the neonatal intensive care unit (NICU). Our patient was successfully extubated on the 4th day of his life, and on the 5th day he was transferred fr om the neonatal intensive care unit (NICU). Objective: To present a case of the effectiveness of therapeutic hypothermia in the case of macrosomy of a fetus born in severe asphyxia: clinical manifestations, changes in laboratory parameters and possible outcome. Materials and methods: Retrospective analysis. This clinical case is described on the basis of the history of the development of a newborn with a large weight, born in severe asphyxia. Results: In the description of this clinical case, characteristic changes in clinical and laboratory parameters in a newborn boy with a diagnosis of severe asphyxia are given. A large fruit. Hypoxic-ischemic encephalopathy of severe severity. Convulsions of a newborn. Conclusion: The clinical case was in the Perinatal Center of Semey in 2021. The newborn underwent stabilization measures, followed by transfer to the neonatal intensive care unit (NICU) of the Perinatal Center (PC) in Semey, wh ere intensive therapy was initiated: invasive respiratory support, therapeutic hypothermia for 72 hours, with correction of metabolic disorders, as well as other laboratory changes. In dynamics, against the background of intensive therapy, the condition improved, the child was transferred for further management to the 5th day of life in the department of pathology of Department of Pathology of Newborns and Nursing of Premature Babies (DPNandNPB).
Nazym M. Ailbayeva1, Gulnar B. Taiorazova1, Aliya R. Alimbaeva1, Sayat Z. Tanatarov1, Zhanargul K. Smailova1, Yuri F. Lobanov2, 1 NJSC Semey Medical University, Semey, Republic of Kazakhstan; 2 Altai State Medical University, Barnaul, Russian Federation.
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Ailbayeva N.M., Alimbaeva A.R., Tanatarov S.Z., Smailova Zh.K., Lobanov Yu.F. Practical aspects of neuroprotective treatment in a newborn with macrosomia born in acute hypoxia // Nauka i Zdravookhranenie [Science & Healthcare]. 2022, (Vol.24) 2, pp. 233-239. doi 10.34689/SH.2022.24.2.029

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