CLINICAL CASE OF DIFFICULTY IN THE DIAGNOSIS OF PULMONARY SARCOIDOSIS IN ADOLESCENTS
Relevance: Currently, there is an increase in the incidence and prevalence of sarcoidosis worldwide. This pathology has a variable course and damage to relatively young people all over the world. The disease is extremely heterogeneous with an unpredictable clinical course.
Objective. To study the diagnostic significance of CD68 immunophenotyping based on lung biopsy materials in pulmonary sarcoidosis.
Materials and methods: The article included the interesting clinical example, in which the diagnosis was difficult in spite of sufficient illustration of the stages of pulmonary sarcoidosis course.
Conclusion: The obtained data of morphological and immunohistochemical studies have practical interest in cases of difficulty in the differential diagnosis of lung tuberculosis and sarcoidosis in order to clinical diagnosis verification.
Maida M. Tussupbekova1, https://orcid.org/0000-0003-3105-4450
Leila M. Stabayeva1, https://orcid.org/0000-0001-8598-1829
Bakhytkali A. Ibraimov2, https://orcid.org/0000-0001-5396-0097
Roza A. Bakenova3, https://orcid.org/0000-0002-5024-9096
Gulnazira N. Imanbayeva1, Raikhan Zh. Nygyzbayeva1
1 Department of Pathology, Karaganda State Medical University,
Karaganda c., the Republic of Kazakhstan;
2 National Scientific Medical Center, Nur-Sultan c., the Republic of Kazakhstan;
3 Medical Centre Hospital of the President’s Affairs Administration of the Republic of Kazakhstan,
Nur-Sultan c., the Republic of Kazakhstan.
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4 Maertzdorf J., et al. Common patterns and disease-related signatures in tuberculosis and sarcoidosis // Proc. Natl. Acad. Sci. USA. 2012; 109, №20; 7853-7858.
5 Tussupbekova M., Bakenova R., Stabayeva L., et al. Clinic - Morphologic and Morphometric Criteria for Differential Diagnosis of Sarcoidosis and Pulmonary Tuberculosis // Open Access Maced J Med Sci. 2019; 7(9); 1480‐1485.
6 Zissel G., Müller-Quernheim J. Cellular Players in the Immunopathogenesis of Sarcoidosis // Clin Chest Med. 2015; 36(4); 549-560.
7 Ungprasert P., Ryu J.H., Matteson E.L. Clinical Manifestations, Diagnosis, and Treatment of Sarcoidosis // Mayo Clin PInnov Qual Outcomes. 2019; 2-3(3); 358-375.
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Tussupbekova M.M., Stabayeva L.M., Ibraimov B.A., Bakenova R.A., Imanbayeva G.N., Nygyzbayeva R.Zh. Clinical case of difficulty in the diagnosis of pulmonary sarcoidosis in adolescents // Nauka i Zdravookhranenie [Science & Healthcare]. 2022, (Vol.24) 3, pp. 227-230. doi 10.34689/SH.2022.24.3.026Похожие публикации:
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