FEATURES OF THE PATHOLOGY DEVELOPMENT OF HUMAN DEMODICOSIS. REVIEW
Relevance. Demodex is the most common parasite found on humans, and yet little is known about its pathogenicity in relation to the ocular surface. The growing interest in demodex over the past 20 years has expanded our understanding of this tick and its pathogenetic role. Despite the growing interest in demodex in the literature, numerous obstacles remain for future research, so the section of this review is devoted to identifying and proposing for future consideration. The lack of uniformity in terms of terminology, diagnostic methods and approach to the treatment of demodex remains an obstacle to future comparisons of studies. This review summarizes current knowledge about demodex and hopes to offer some recommendations for future directions in the study of demodex in humans.
Search strategy. The study examined full-text publications in English and Russian, which are devoted features of the pathology development of human demodicosis. In the process of searching for literature, the following search engines were used: Pubmed, Web of science, Cyberleninka, Google Scholar by keywords. The time period was designated 2007-2022. 299 publications were identified on this topic. Of these, 61 publications corresponded to the purpose of our study. Inclusion criteria: Publications of the level of evidence A, B: meta-analyses, systematic reviews, cohort and cross-sectional studies. Exclusion criteria: summary reports, newspaper articles and personal messages.
Results and conclusions. Papulopustular rosacea and demodecosis are common facial skin diseases that can be difficult to diagnose clinically. In addition to well-known clinical signs such as vascular signs and papules, in our study of patients with known papulopustular rosacea or demodecosis, we have shown that other clinical signs are also often present (inconspicuous follicular scales on the face, dandruff, folliculitis on the scalp, itching of the face or scalp). Therefore, the presence of these signs and symptoms should encourage dermatologists to conduct further diagnostic tests (for example, the recently described test based on the high density of demodex mites observed in these conditions) to ensure an accurate diagnosis.
Marina N. Lemishenko1, https://orcid.org/0000-0001-6596-2305
Zaituna A. Khismetova1, https://orcid.org/0000-0001-5937-3045
Zhibek R. Asarbekova2, Kassym Zh. Yermekpayev3,
1 NCJSC “Semey medical university”, Semey, Republic of Kazakhstan;
2 MU "Pobeda", Semey, Republic of Kazakhstan;
3 NCJSC « Semey medical university», resident, Semey, Republic of Kazakhstan.
1. Aumond S., Bitton E. Palpebral and facial skin infestation by Demodex folliculorum // Contact lens & anterior eye : the journal of the British Contact Lens Association. 2020. № 2 (43). C. 115–122.
2. Ayyildiz T., Sezgin F.M. The Effect of Ocular Demodex Colonization on Schirmer test and OSDI Scores in Newly Diagnosed Dry Eye Patients // Eye & contact lens. 2020. (46 Suppl 1). C. S39–S41.
3. Bevins C.L., Liu F.T. Rosacea: skin innate immunity gone awry? // Nature medicine. 2007. № 8 (13). C. 904–906.
4. Bitton E., Ngo W., Dupont P. Eyelid hygiene products: A scoping review // Contact lens & anterior eye : the journal of the British Contact Lens Association. 2019. № 6 (42). C. 591–597.
5. Cheng S. et al. Intense Pulsed Light Therapy for Patients with Meibomian Gland Dysfunction and Ocular Demodex Infestation // Current medical science. 2019. № 5 (39). C. 800–809.
6. Cheung I. et al. In vitro anti-demodectic effects and terpinen-4-ol content of commercial eyelid cleansers // Contact lens & anterior eye : the journal of the British Contact Lens Association. 2018. № 6 (41). C. 513–517.
7. Craig J.P. et al. Preclinical development of MGO Manuka Honey microemulsion for blepharitis management // BMJ open ophthalmology. 2017. № 1 (1), P.1-12.
8. Elston C.A., Elston D.M. Demodex mites // Clinics in Dermatology. 2014. № 6 (32). C. 739–743.
9. Elston D.M. Demodex mites: facts and controversies // Clinics in dermatology. 2010. № 5 (28). C. 502–504.
10. Ertaş R. et al.. The rapid effect of pulsed dye laser on demodex density of facial skin // Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology. 2019. № 3 (21). C. 123–126.
11. Fishman H.A., Periman L.M., Shah A.A. Real-Time Video Microscopy of In Vitro Demodex Death by Intense Pulsed Light // Photobiomodulation, photomedicine, and laser surgery. 2020. № 8 (38). C. 472–476.
12. Foley R. et al. Demodex: a skin resident in man and his best friend // Journal of the European Academy of Dermatology and Venereology : JEADV. 2021. № 1 (35). C. 62–72.
13. Frame K. et al. Comparing the in vitro effects of MGO TM Manuka honey and tea tree oil on ocular Demodex viability // Contact lens & anterior eye : the journal of the British Contact Lens Association. 2018. № 6 (41). C. 527–530.
14. Fromstein S.R. et al. Demodex blepharitis: clinical perspectives // Clinical optometry. 2018. (10). C. 57–63.
15. Gao Y.Y. et al. Clinical treatment of ocular demodecosis by lid scrub with tea tree oil // Cornea. 2007. № 2 (26). C. 136–143.
16. Gazi U., Taylan-Ozkan A., Mumcuoglu K.Y. Immune mechanisms in human and canine demodicosis: A review // Parasite immunology. 2019. № 12 (41), P.1-7.
17. Holzchuh F.G. et al. Clinical treatment of ocular Demodex folliculorum by systemic ivermectin // American journal of ophthalmology. 2011. № 6 (151), P.1030-1034.
18. Horváth A. et al. Risk factors and prevalence of Demodex mites in young adults // Acta microbiologica et immunologica Hungarica. 2011. № 2 (58). C. 145–155.
19. Huang Y. et al. Ocular demodicosis as a risk factor of pterygium recurrence // Ophthalmology. 2013. № 7 (120). C. 1341–1347.
20. Jarmuda S. et al. Potential role of Demodex mites and bacteria in the induction of rosacea // Journal of medical microbiology. 2012. № Pt 11 (61). C. 1504–1510.
21. Kabat A.G. In vitro demodicidal activity of commercial lid hygiene products // Clinical ophthalmology (Auckland, N.Z.). 2019. (13). C. 1493–1497.
22. Karakurt Y., Zeytun E. Evaluation of the Efficacy of Tea Tree Oil On the Density of Demodex Mites (Acari: Demodicidae) and Ocular Symptoms In Patients With Demodectic Blepharitis // The Journal of parasitology. 2018. № 5 (104). C. 473–478.
23. Kheirkhah A. et al. Corneal manifestations of ocular demodex infestation // American journal of ophthalmology. 2007. № 5 (143),P.743-749.
24. Kheirkhah A. et al. Fluorescein dye improves microscopic evaluation and counting of demodex in blepharitis with cylindrical dandruff // Cornea. 2007. № 6 (26). C. 697–700.
25. Kim J.H., Chun Y.S., Kim J.C. Clinical and immunological responses in ocular demodecosis // Journal of Korean medical science. 2011. № 9 (26). C. 1231–1237.
26. Kim J.T. et al. Tear cytokines and chemokines in patients with Demodex blepharitis // Cytokine. 2011. № 1 (53). C. 94–99.
27. Kligman A.M., Christensen M.S. Demodex folliculorum: requirements for understanding its role in human skin disease // The Journal of investigative dermatology. 2011. № 1 (131). C. 8–10.
28. Kulac M. et al. Clinical importance of Demodex folliculorum in patients receiving phototherapy // International journal of dermatology. 2008. № 1 (47). C. 72–77.
29. Lee S.H. et al. The relationship between demodex and ocular discomfort // Investigative ophthalmology & visual science. 2010. № 6 (51). C. 2906–2911.
30. Li J. et al. Correlation between ocular Demodex infestation and serum immunoreactivity to Bacillus proteins in patients with Facial rosacea // Ophthalmology. 2010. № 5 (117).
31. Liang L. et al. Ocular demodicosis as a potential cause of pediatric blepharoconjunctivitis // Cornea. 2010. № 12 (29). C. 1386–1391.
32. Liang L. et al. Significant correlation between meibomian gland dysfunction and keratitis in young patients with Demodex brevis infestation // The British journal of ophthalmology. 2018. № 8 (102). C. 1098–1102.
33. Liang L., Ding X., Tseng S.C.G. High prevalence of demodex brevis infestation in chalazia // American journal of ophthalmology. 2014. № 2 (157), P.1-20.
34. Liu J., Sheha H., Tseng S.C.G. Pathogenic role of Demodex mites in blepharitis // Current opinion in allergy and clinical immunology. 2010. № 5 (10). C. 505–510.
35. López-Ponce D. et al. High prevalence of Demodex spp. infestation among patients with posterior blepharitis: correlation with age and cylindrical dandruff // Archivos de la Sociedad Espanola de Oftalmologia. 2017. № 9 (92). C. 412–418.
36. Luo X. et al. Ocular Demodicosis as a Potential Cause of Ocular Surface Inflammation // Cornea. 2017. № Suppl 1 (36 Suppl 1). C. S9–S14.
37. Messaoud R. et al. Improvement in ocular symptoms and signs in patients with Demodex anterior blepharitis using a novel terpinen-4-ol (2.5%) and hyaluronic acid (0.2%) cleansing wipe // Clinical ophthalmology (Auckland, N.Z.). 2019. (13). C. 1043–1054.
38. Murphy O., O’Dwyer V., Lloyd-McKernan A. The efficacy of tea tree face wash, 1, 2-Octanediol and microblepharoexfoliation in treating Demodex folliculorum blepharitis // Contact lens & anterior eye : the journal of the British Contact Lens Association. 2018. № 1 (41). C. 77–82.
39. Navel V. et al. Efficacy of treatments for Demodex blepharitis: A systematic review and meta-analysis // The ocular surface. 2019. № 4 (17). C. 655–669.
40. Ngo W., Jones L., Bitton E. Short-Term Comfort Responses Associated With the Use of Eyelid Cleansing Products to Manage Demodex folliculorum // Eye & contact lens. 2018. (44 Suppl 2). C. S87–S92.
41. Nicholls S.G. et al. Demodex treatment in external ocular disease: the outcomes of a Tasmanian case series // International ophthalmology. 2016. № 5 (36). C. 691–696.
42. Nicholls S.G. et al. Demodex species in human ocular disease: new clinicopathological aspects // International ophthalmology. 2017. № 1 (37). C. 303–312.
43. O’Reilly N. et al. Demodex-associated bacterial proteins induce neutrophil activation // The British journal of dermatology. 2012. № 4 (166). C. 753–760.
44. O’Reilly N., Menezes N., Kavanagh K. Positive correlation between serum immunoreactivity to Demodex-associated Bacillus proteins and erythematotelangiectatic rosacea // The British journal of dermatology. 2012. № 5 (167). C. 1032–1036.
45. Palamar M. et al. Evaluation of dry eye and meibomian gland dysfunction with meibography in patients with rosacea // Cornea. 2015. № 5 (34). C. 497–499.
46. Papageorgiou P. et al. Treatment of rosacea with intense pulsed light: significant improvement and long-lasting results // The British journal of dermatology. 2008. № 3 (159). C. 628–632.
47. Petropoulos S. et al. The chemical composition, nutritional value and antimicrobial properties of Abelmoschus esculentus seeds // Food & function. 2017. № 12 (8). C. 4733–4743.
48. Qiu T.Y., Yeo S., Tong L. Satisfaction and convenience of using terpenoid-impregnated eyelid wipes and teaching method in people without blepharitis // Clinical ophthalmology (Auckland, N.Z.). 2018. (12). C. 91–98.
49. Randon M. et al. In vivo confocal microscopy as a novel and reliable tool for the diagnosis of Demodex eyelid infestation // The British journal of ophthalmology. 2015. № 3 (99). C. 336–341.
50. Rather P.A., Hassan I. Human demodex mite: the versatile mite of dermatological importance // Indian journal of dermatology. 2014. № 1 (59). C. 60–66.
51. Romanowski E.G. et al. In Vitro Evaluation of a Hypochlorous Acid Hygiene Solution on Established Biofilms // Eye & contact lens. 2018. № Suppl 2 (44 Suppl 2). C. S187–S191.
52. Salem D.A.B. et al. Evaluation of the efficacy of oral ivermectin in comparison with ivermectin-metronidazole combined therapy in the treatment of ocular and skin lesions of Demodex folliculorum // International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases. 2013. № 5 (17).P.342-347.
53. Schaller M., Pietschke K. Successful therapy of ocular rosacea with topical ivermectin // The British journal of dermatology. 2018. № 2 (179). C. 520–521.
54. Sedzikowska A., Oseka M., Skopinski P. The impact of age, sex, blepharitis, rosacea and rheumatoid arthritis on Demodex mite infection // Archives of medical science : AMS. 2018. № 2 (14). C. 353–356.
55. Tarkowski W., Moneta-Wielgoś J., Młocicki D. Do Demodex mites play a role in pterygium development? // Medical hypotheses. 2017. (98). C. 6–10.
56. Tighe S., Gao Y.-Y., Tseng S.C.G. Terpinen-4-ol is the Most Active Ingredient of Tea Tree Oil to Kill Demodex Mites // Translational vision science & technology. 2013. № 7 (2). C. 2.
57. Wesolowska M. et al. Prevalence of Demodex spp. in eyelash follicles in different populations // Archives of medical science : AMS. 2014. № 2 (10). C. 319–324.
58. Wong K. et al. The effect of BlephadexTM Eyelid Wipes on Demodex mites, ocular microbiota, bacterial lipase and comfort: a pilot study // Contact lens & anterior eye : the journal of the British Contact Lens Association. 2019. № 6 (42). C. 652–657.
59. Wu M. et al. Evaluation of the ocular surface characteristics and Demodex infestation in paediatric and adult blepharokeratoconjunctivitis // BMC ophthalmology. 2019. № 1 (19),P.2-7.
60. Zhao Y.E. et al. Retrospective analysis of the association between Demodex infestation and rosacea // Archives of dermatology. 2010. № 8 (146). C. 896–902.
61. Zhao Y.E. et al. Association of blepharitis with Demodex: a meta-analysis // Ophthalmic epidemiology. 2012. № 2 (19). C. 95–102.
Количество просмотров: 226
Категория статей:
Обзор литературы
Библиографическая ссылка
Lemishenko M.N., Khismetova Z.A., Asarbekova Zh.R., Yermekpayev K.Zh. Features of the pathology development of human demodicosis. Review // Nauka i Zdravookhranenie [Science & Healthcare]. 2022, (Vol.24) 5, pp. 196-202. doi 10.34689/SH.2022.24.5.024Похожие публикации:
ДИАГНОСТИЧЕСКАЯ И ТЕРАПЕВТИЧЕСКАЯ ЛАПАРОСКОПИЯ ПРИ ТРАВМАХ ЖИВОТА. ОБЗОР ЛИТЕРАТУРЫ.
КАЧЕСТВО ЖИЗНИ И МЕТОДЫ ЕГО ОЦЕНКИ ПРИ ПЕРВИЧНОМ БИЛИАРНОМ ХОЛАНГИТЕ
ЛЕКАРСТВЕННО-ИНДУЦИРОВАННЫЕ ПОРАЖЕНИЯ ПЕЧЕНИ И ГЕНДЕРНЫЕ РАЗЛИЧИЯ
INTERRELATION OF INTRAABDOMINAL HYPERTENSION AND MARKERS OF GASTROINTESTINAL TRACT INJURY IN PATIENTS WITH MULTIORGAN DYSFUNCTION
НОВЫЕ СИНДРОМЫ И ПАТТЕРНЫ ОСТРОЙ ОККЛЮЗИИ КОРОНАРНЫХ АРТЕРИЙ. ОБЗОР ЛИТЕРАТУРЫ.