ОСОБЕННОСТИ ГЕНЕТИЧЕСКОГО ПОЛИМОРФИЗМА НЕАЛКОГОЛЬНОЙ ЖИРОВОЙ БОЛЕЗНИ ПЕЧЕНИ
Актуальность: Глобальная распространенность неалкогольной жировой болезни печени (НАЖБП), а также ее неуклонный рост в последние десятилетия является одной из важных проблем медицинских исследований. Изучение генетической предрасположенности к заболеванию является одной из важных задач по ранней диагностике и профилактике неблагоприятных исходов и смертности .
Цель: Обьединить современные сведения о наиболее изученных генетических ассоциациях НАЖБП, которые связаны с восприимчивостью и прогресссированием заболевания.
Стратегия поиска: Проведен поиск научных публикаций (мета-анализы, когортные исследования) в поисковых системах E–Library, PubMed, Google Scholar за 2010-2022 г.г. Также проанализированы несколько публикаций, связанных с данной патологией и содержащих первые сведения о генетических аспектах НАЖБП, опубликованные до 2010 года. Ключевые слова для поиска включали «неалкогольная жировая болезнь печени», «эпидемиология», «генетика», «тяжесть течения». В соответствии с алгоритмом отбора литературы анализу подверглись 145 публикации.
Результаты и выводы: В данном обзоре рассматривается вопрос распространенности НАЖБП, ее генетических предикторов, влияющих на восприимчивость и прогрессирование заболевания. По данным мета-анализов выявлены несколько генов-кандидатов, напрямую коррелирующие с агрессивным течением и неблагоприятным исходом НАЖБП. Необходимы дальнейшие исследования, которые помогут в поисках стратегических направлений с целью снижения заболеваемости среди всех категорий пациентов с данной патологией. Соответственно, избранное направление является одним из трендов мировых медицинских исследований.
Сауле А. Алиева1, https://orcid.org/0000-0001-5098-9206
Игорь Г. Никитин1, https://orcid.org/0000-0003-1699-0881
Евгений И. Дедов1, https://orcid.org/0000-0002-9118-3708
Ольга А. Эттингер1, https://orcid.org/0000-0002-1237-3731
Лаура А. Пак2, https://orcid.org/0000-0002-5249-3359
Лаура Т. Касым3, https://orcid.org/0000-0003-4448-6455
Куанткан А. Жабагин4, https://orcid.org/0000-0002-4304-5132
Айнур С. Крыкпаева2, http://orcid.org/0000-0001-7701-9832
Асем Р. Махатова2, https://orcid.org/0000-0003-4127-7279
Ақжан Б. Жұматай2, https://orcid.org/0000-0003-4558-5316
Aсель Э. Какытаева2, https://orcid.org/0000-0003-1943-5859
1 Кафедра госпитальной терапии № 2 им. акад. Г.И. Сторожакова, Лечебный факультет ФГАОУ ВО “Российский национальный исследовательский медицинский университет им. Н.И. Пирогова” Минздрава России, Москва, Российская Федерация;
2 НАО «Медицинский университет Семей», г. Семей, Республика Казахстан;
3 НАО «Медицинский Университет Астана», г. Астана, Республика Казахстан;
4 Центр ядерной медицины и онкологии, г. Семей, Республика Казахстан.
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Алиева С.А., Никитин И.Г., Дедов Е.И., Эттингер О.А., Пак Л.А., Касым Л.Т., Жабагин К.Т., Крыкпаева А.С., Махатова А.Р., Жұматай А.Б., Какытаева A.Э. Особенности генетического полиморфизма неалкогольной жировой болезни печени // Наука и Здравоохранение. 2023. 1(Т.25). С. 209-222. doi 10.34689/SH.2023.25.1.025Похожие публикации:
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