Online ISSN: 3007-0244,
Print ISSN:  2410-4280
СОВРЕМЕННОЕ СОСТОЯНИЕ ПРОБЛЕМЫ СТАНОВЛЕНИЯ И ДИНАМИКИ МИКРОБИОТЫ У МЛАДЕНЦЕВ. ОБЗОР ЛИТЕРАТУРЫ
Актуальность: Микробиом человека представляет собой сложную и динамичную экосистему. Он играет важную роль в метаболизме и физиологии хозяина. Исследования показывают критическую взаимосвязь между микробиомом человека и метаболизмом хозяина. Взаимодействие между микробиомом и метаболизмом хозяина влияет на здоровье и болезни человека. Требуются дополнительные исследования с использованием новых технологий, чтобы лучше понять формирование микробиоты. Цель: Общая характеристика современных сведений о траекториях формирования микробиома младенцев. Стратегия поиска: Проведен поиск научных публикаций, находящихся в открытом доступе, с использованием следующих баз данных научных публикаций и специализированных поисковых систем: PubMed, Google Scholar, Web of Science, Сyberleninca. Проанализирован ряд оригинальных публикаций и обзоров по направлению исследования за последние 10 лет. В результате поиска нами было изучено 1695 зарубежных и русскоязычных публикаций, из них в данный обзор вошли 78 публикаций. Критерии включения: Публикации уровня доказательности А, В: мета-анализы, систематические обзоры, когортные и поперечные исследования. Критерии исключения: краткие отчеты, газетные статьи и мнение экспертов в виде коротких сообщений. Результаты и выводы: Мы проанализировали современные данные по микробиому кишечника младенцев и оценили влияние способа родов и кормления на его формирование. В отличие от младенцев, родившихся естественным путем, микробиота кишечника младенцев, родившихся путем кесарева сечения, показала значительно меньшее сходство с их материнским микробиомом. Значительное влияние на состав и функции микробиоты на ранних стадиях оказывает вид вскармливания (естественное или искусственное), а также введение прикорма в рацион младенцев. Состав микробиоты и экологическая сеть имели отличительные особенности под влиянием социальных детерминантов здоровья. Эти результаты создают основу для понимания взаимодействия между микробиомом кишечника и организмом человека в раннем возрасте.
Зарина Қ. Мейірманова1, https://orcid.org/0000-0002-4997-6704 Марина А. Моренко1, https://orcid.org/0000-0001-9553-3560 Ксения В. Шнайдер1, https://orcid.org/0000-0002-4919-1878 Бакыткуль Ж. Токтабаева2, https://orcid.org/0000-0001-5899-1247 Самат С. Кожахметов3, https://orcid.org/0000-0001-9668-0327 Ирина Н. Захарова4, Арайлым Қ. Дүйсебаева1, https://orcid.org/0000-0003-4249-7652 Мадина Р. Гатауова1, https://orcid.org/0000-0002-6517-192Х 1 НАО «Медицинский университет Астана», г. Астана, Республика Казахстан; 2 НАО «Медицинский университет Семей», г. Семей, Республика Казахстан; 3 ЧУ «Центр наук о жизни» АОО «Назарбаев Университет», г. Астана, Республика Казахстан; 4 Кафедра педиатрии им. акад. Г.Н. Сперанского ФГБОУ ДПО РМАНПО Минздрава России, ФГАУ «Национальный медицинский исследовательский центр здоровья детей», г. Москва, Россия Федерация.
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Мейірманова З.Қ., Моренко М.А., Шнайдер К.В., Токтабаева Б.Ж., Кожахметов С.С., Захарова И.Н., Дүйсебаева А.Қ., Гатауова М.Р. Современное состояние проблемы становления и динамики микробиоты у младенцев. Обзор литературы // Наука и Здравоохранение. 2023. 1(Т.25). С. 232-242. doi 10.34689/SH.2023.25.1.027

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