PREDICTIVE VALUE OF HEMOGRAM INDICES IN THE EVALUATION OF THE 30-DAY MORTALITY RISKS IN COVID-19 DEPENDING ON GENDER
The aim. SARS-CoV-2 infection can have a profound effect on the functioning of the immune system. Differences in the prognostic significance of hemogram indices raise the question of existing gender immunological differences. The study aims to compare the significance of the hematological indices for the evaluation of the 30-day mortality risk in men and women.
Materials and methods. A retrospective observational study included 1419 patients with a positive PCR nasopharyngeal swab for COVID-19 hospitalized between 1 May 2021 and 30 August 2021 at Karaganda clinical hospital, Kazakhstan. Laboratory tests performed upon admission included a complete blood count to obtain NLR, NPR, PLR, and SII. A receiver operating characteristic curve was performed to analyze the efficiency of the prognosis of the 30-day mortality. Using univariate and multivariate Cox regression was analyzed the association of neutrophil indices with mortality.
Results. In total, 95 people (8.5%) died in 30 days, the mortality rate among men was 1,9 times higher than among women. The value of SII and TLR in predicting mortality in women was AUC 0.714 and 0.624 respectively. In men, NLR had the highest AUC of 0.736.
Conclusion. Elevated NLR, NPR, and SII have significant predictive value in COVID-19 mortality, especially NPR in females and NLR in males.
Lyudmila G. Turgunova1, https://orcid.org/0000-0002-6962-4247
Irina V. Mekhantseva1, https://orcid.org/0000-0001-6601-8172
Yelena M. Laryushina1, https://orcid.org/0000-0002-9590-690X
Assel R. Alina1, https://orcid.org/0000-0002-3229-1506
Anar A. Turmukhambetova2, https://orcid.org/0000-0002-4668-3295
1 Karaganda Medical University, Department of Internal Medicine, Karaganda, Kazakhstan;
2 Karaganda Medical University, Department of Strategic Development and Science, Karaganda, Kazakhstan.
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Актуальная тема COVID-19
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Turgunova L.G., Mekhantseva I.V., Laryushina Ye.M., Alina A.R., Turmukhambetova A.A. Predictive value of hemogram indices in the evaluation of the 30-day mortality risks in COVID-19 depending on gender // Nauka i Zdravookhranenie [Science & Healthcare]. 2023, (Vol.25) 3, pp. 7-15. doi 10.34689/SH.2023.25.3.001Похожие публикации:
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