INVOLVEMENT OF THE SEROTONIN SYSTEM IN THE DEVELOPMENT OF PULMONARY ARTERIAL HYPERTENSION
Pulmonary arterial hypertension is a multifactorial disease characterized by vasoconstriction and pulmonary vascular remodeling, inflammation and thrombosis. Remodeling of the pulmonary vascular wall leads to an increase in pressure in the pulmonary artery, which increases the load on the right heart and ultimately leads to right ventricular failure [7, 10]. Despite significant progress in treatment, the prognosis of the disease remains unfavorable - in pediatric practice mortality within five years after diagnosis ranges from 25 to 60% [63]. Due to the frequent late diagnosis of pulmonary arterial hypertension and the severe consequences of this condition, the issue of identifying and studying biological markers of pulmonary arterial hypertension is actual problem. Although a growing body of research confirms that pulmonary artery smooth muscle endothelial cells, as well as platelets, play a role in the pathogenesis of pulmonary arterial hypertension, it is still unclear what these factors have in common. Platelets, releasing a wide variety of chemokines, can actively influence the pathogenesis and development of pulmonary arterial hypertension. The effect of platelet serotonin on the endothelium is mediated through vascular constriction and an increase in vascular resistance [9]. Currently, the role of serotonin and its metabolism in the pathogenesis of pulmonary arterial hypertension is widely discussed. This article presents a literature review, the purpose of which is to demonstrate the role of the serotonin system in the development of pulmonary arterial hypertension. The review includes data from articles (original clinical trials and literature reviews) found in the Scopus, Web of Science, Pubmed databases according to keywords. Sources published from 2012 to 2023 were used.
Mariya D. Ospanova1, Farida A. Mindubayeva1, Dinara I. Sadykova2 1 «Medical University of Karaganda» NСJSC, Karaganda, Republic of Kazakhstan; 2 Kazan State Medical University, Kazan, Russian Federation.
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Ospanova M.D., Mindubayeva F.A., Sadykova D.I. Involvement of the serotonin system in the development of pulmonary arterial hypertension // Nauka i Zdravookhranenie [Science & Healthcare]. 2023, (Vol.25) 5, pp. 174-183. DOI 10.34689/SH.2023.25.5.023

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