THE ROLE OF BSMI AND APAI POLYMORPHISMS OF THE VITAMIN D RECEPTOR GENE IN THE DEVELOPMENT OF LOW BONE MINERAL DENSITY IN ADULTS. LITERATURE REVIEW
Background. Osteoporosis is a systemic skeletal disease characterized by a decrease in bone mineral density (BMD), which leads to an increased risk of fractures and greater bone fragility [1]. The global prevalence of osteoporosis is estimated to be 18.3%. Gender and genetics are non-modifiable risk factors for osteoporosis, whereas other factors (modifiable ones) can be influenced, such as diet, physical activity, and lifestyle. Vitamin D plays a crucial role in bone metabolism and is essential for the prevention of osteoporosis (OP). In recent years, numerous studies have been conducted to explore the correlation between VDR gene variants and osteoporosis risk, suggesting the presence of ethnic differences in the genetic association with osteoporosis. However, there is still no definitive evidence confirming their impact in the studies conducted so far.
The aim was of this review is to examine the available literature on the role of vitamin D and the association of BsmI and ApaI polymorphisms in the development of low mineral density.
Search Strategy: A systematic search was conducted in the electronic databases PubMed and Google Scholar using the following keywords: “osteoporosis,” “BsmI,” “ApaI,” “VDR gene,” “bone mineral density, and “vitamin D.” The search was limited to English-language studies published between 2014 and 2024. A total of 24 sources were reviewed. The article selection for this review was conducted by the authors, who identified relevant studies and excluded those that did not meet the inclusion criteria.
Conclusion. Although some studies on various populations have identified an association between several VDR gene polymorphisms and bone mineral density (BMD), many questions in this area remain unresolved. Research on VDR gene polymorphisms has shown that their impact on low BMD can yield different results across populations.
Madina Madiyeva1, https://orcid.org/0000-0001-6431-9713
Alida Kaskabayeva1, https://orcid.org/0000-0002-5184-214X
Nurgul Kultumanova1, https://orcid.org/0009-0005-2475-2009
Gulzhan Bersimbekova1, https://orcid.org/0000-0002-9416-5054
Gulnur Kanapiyanova1, https://orcid.org/0000-0002-8102-5220
Zhanna Sarmanova1, https://orcid.org/0009-0000-4728-511X
Makpal Sabyrkyzy1, https://orcid.org/0009-0006-8902-7593
1 NCJSC «Semey Medical University»,
Semey, Republic of Kazakhstan.
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Madiyeva M., Kaskabayeva A., Kultumanova N., Bersimbekova G., Kanapiyanova G., Sarmanova Zh., Sabyrkyzy M. The Role of BsmI and ApaI Polymorphisms of the Vitamin D Receptor Gene in the Development of Low Bone Mineral Density in Adults. Literature Review // Nauka i Zdravookhranenie [Science & Healthcare]. 2024. Vol.26 (6), pp. 160-176. doi 10.34689/SH.2024.26.6.017Похожие публикации:
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