CLINICAL CASE: POSTSTREPTOCOCCAL ARTHRITIS ASSOCIATED WITH COVID-19
Introduction: Poststreptococcal arthritis associated with COVID-19 is a rare but severe inflammatory condition that arises following a prior COVID-19 infection, contributing to complications of a preceding streptococcal infection. It serves as an example of how COVID-19 may precede and trigger autoimmune diseases. In recent years, there has been an increase in cases associated with infections linked to COVID-19, highlighting the importance of studying the long-term health consequences of the pandemic and the rising incidence of infectious disorders.
The purpose of the study: To draw the attention of rheumatologists, general practitioners, and infectious disease specialists to the risks of developing autoimmune diseases following COVID-19 infection, as well as to emphasize the importance of early diagnosis, prevention, and comprehensive management of COVID-19 to minimize long-term complications, including autoimmune disorders.
Materials and Methods: To diagnose this condition, patient anamnesis and clinical-laboratory data were collected. Additionally, a review of global publications from the last five years was conducted, examining the role of COVID-19 as a precursor to autoimmune diseases and a predictor of complications from various infectious diseases that may lead to autoimmune pathology.
Results: Based on anamnesis, clinical and laboratory, instrumental data a diagnosis of poststreptococcal arthritis associated with COVID-19 was established. The investigation results confirmed the presence of an inflammatory (streptococcal) process related to a previous COVID-19 infection, suggesting a possible link between past infection and the development of an autoimmune disorder.
Conclusions: COVID-19 causes a cytokine storm, leading to a decrease in T-lymphocyte levels, suppression of cellular immunity, and increased susceptibility to other infections. In this clinical case, poststreptococcal arthritis developed in a patient with laboratory-confirmed immune alterations following COVID-19. This case underscores the importance of primary and secondary prevention of infectious diseases, as well as the necessity of monitoring the immune status of patients who have recovered from COVID-19 to ensure timely detection and treatment of potential autoimmune complications.
Nogayeva Maral Gazizovna – Candidate of Medical Sciences, Professor of the Department of Rheumatology, Kazakh National Medical University named after S.D. Asfendiyarov, e-mail: maral.nogaeva@xmail.ru, Almaty, +7 708 800 52 65. https://orcid.org/0000-0003-1182-5967
Atasheva Arailim Askarbekovna – Assistant of the Department of Rheumatology, Kazakh National Medical University named after S.D. Asfendiyarov, e-mail: harika07@mail.ru, Almaty, +7 701 474 73 57. https://orcid.org/0000-0002-9825-9461
Omargali Kymbat Seidullakyzy – First-year resident-rheumatologist of the Department of Rheumatology, Kazakh National Medical University named after S.D. Asfendiyarov, e-mail: kymbat.omargalieva@mail.ru, Almaty, +7 775 846 92 03. https://orcid.org/0009-0004-8489-8512
Nurgaliyeva Bayan – Doctor of Medical Sciences, MSP, Head of the Department of Propedeutics of Internal Diseases at NPJSC "Kazakh National Medical University named after S.D. Asfendiyarov", Chief Physician of the "Kazmed Company" Clinic, Almaty, Republic of Kazakhstan. ORCID: 0000-0003-2555-8644; Postal Address: 050012, Almaty, Tole Bi Street, 94, Department of Propedeutics of Internal Diseases; E-mail: nurgalieva.b@kaznmu.kz, +7 701 210 62 81
1. Аксенова А.В., Шостак Н.А., Гусева О.А. Постстрептококковые заболевания в клинической практике // Вестник оториноларингологии. 2016. Т.81(2). С.39-43. https://doi.org/10.17116/otorino201681239-43
2. Аронова Е.С., Белов Б.С. Полиартрит, ассоциированный с COVID-19. Современная ревматология. 2021. С. 76-79. doi.org/10.14412/1996-7012-2021-5-76-79
3. Насонов Е.Л. Аутоиммунитет при COVID-19: патогенез и клинические последствия // International Journal of Molecular Sciences. 2021. Т. 59(1). С. 5-9.
4. Карпович Г.С., Куимова И.В., Серова Ю.С. COVID-19 как вероятный триггерный фактор аутоиммунных заболеваний у детей // Журнал эпидемиологии и инфекционных заболеваний. 2022. Т.101(3). С. 93-100. DOI: https://dx.doi.org/10.18565/epidem.2022.12.1.93-1007
5. Министерство здравоохранения Республики Казахстан Коронавирусная инфекция COVID-19 у взрослых https://diseases.medelement.com/disease/коронавирусная-инфекция-cоvid-19-у-взрослых-6-редакция-кп-рк-2022/17238// (дата обращения: 25.02.2021)
6. Саидахмедова З.И., Махмудова У.И., Давлатова Ш.К. Новые взгляды на постстрептококковый артрит // Новости образования: исследования в 21 веке. 2024. Т.2(21). С.14-25.
7. Тарадин Г.Г., Куглер Т.Е., Маловичко И.С., Кононенко Л.В. Острый артрит, ассоциированный с COVID-19 // Альманах клинической медицины. 2022. Т.50(2). С. 139-141.
8. Ayaka Ohashi, Masanori A Murayama, Yoshige Miyabe, Kazuo Yudoh, Chie Miyabe Streptococcal infection and autoimmune diseases // Front Immunol. 2024 Feb 23:15:1361123. doi: 10.3389/fimmu.2024.1361123. eCollection 2024.
9. Burhan Fatih Kocyigit, Ahmet Akyol. Reactive arthritis after COVID-19: a case-based review // Rheumatol Int. 2021 Nov;41(11):2031-2039. doi: 10.1007/s00296-021-04998-x.
10. Cunningham M.W. Pathogenesis of group A streptococcal infections. Clin Microbiol Rev. 2000 Jul;13(3):470-511. doi: 10.1128/CMR.13.3.470.
11. Maroua Slouma, Maissa Abbes, Takoua Mehmli, Rim Dhahri, Leila Metoui, Imen Gharsallah, Bassem Louzir. Reactive arthritis occurring after COVID-19 infection: a narrative review // Infection. 2023 Feb;51(1):37-45. doi: 10.1007/s15010-022-01858-z. Epub 2022 Jun 2.
12. Michael Ehrenfeld, Angela Tincani, Laura Andreoli, Marco Cattalini, Assaf Greenbaum, Darja Kanduc, Jaume Alijotas-Reig, Vsevolod Zinserling, Natalia Semenova, Howard Amital, Yehuda Shoenfeld. Covid-19 and autoimmunity // Autoimmun Rev. 2020 Aug;19(8):102597. doi: 10.1016/j.autrev.2020.102597.
13. Waleed H Mahallawi, Talal M. Aljeraisi. Infection with SARS-CoV-2 primes immunological memory in human nasal-associated lymphoid tissue // Clin Immunol. 2021 Oct:231:108850. doi: 10.1016/j.clim.2021.108850.
Количество просмотров: 45
Категория статей:
Клинический случай
Библиографическая ссылка
Nogayeva M.G., Atasheva A.A., Omargali K.S. Nurgalieva B.K. Clinical case: poststreptococcal arthritis associated with COVID-19 // Nauka i Zdravookhranenie [Science & Healthcare]. 2025. Vol.27 (1), pp. 267-273. doi 10.34689/SH.2025.27.1.029Похожие публикации:
CLINICAL CASE: POSTSTREPTOCOCCAL ARTHRITIS ASSOCIATED WITH COVID-19
SYSTEMIC RETINOIDS IN THE MANAGEMENT OF MODERATE TO-SEVERE ACNE: A CLINICAL CASE STUDY
ВАРИАНТ ХИРУРГИЧЕСКОГО ЛЕЧЕНИЯ СИНОВИАЛЬНОЙ САРКОМЫ МЯГКИХ ТКАНЕЙ ЛИЦА
ПОЛНАЯ ТРАНСПОЗИЦИЯ ОРГАНОВ (SITUS VISCERUM INVERSUS TOTALIS) НА ПРИМЕРЕ КЛИНИЧЕСКОГО СЛУЧАЯ
COMMUNITY-ACQUIRED PNEUMONIA IN PREGNANT. CLINICAL CASE.