PREDICTORS OF ANTIVIRAL THERAPY INEFFECTIVENESS IN CHRONIC HEPATITIS C: A MATCHED CASE-CONTROL STUDY IN ALMATY, A MAJOR METROPOLIS OF KAZAKHSTAN
This study aims to identify factors contributing to the ineffectiveness of antiviral therapy in patients with chronic hepatitis C (CHC) in Almaty. The rising prevalence and mortality associated with CHC, both in Kazakhstan and globally, underscore the need to improve treatment strategies. Despite the high efficacy of direct-acting antiviral agents (DAAs), some patients fail to achieve a sustained virological response (SVR). This retrospective case-control study included 136 CHC patients treated at healthcare facilities in Almaty, focusing on those who did not attain SVR. Variables such as demographic characteristics, virological status, liver disease stage, comorbidities, lifestyle factors, treatment regimens, and adherence to therapy were analyzed. Logistic regression identified risk factors for non-response to treatment, including comorbid conditions (arterial hypertension, hepatocellular carcinoma) and lifestyle factors. The findings highlight the complexity of CHC treatment in Almaty, emphasizing the importance of personalized approaches that address comorbidities and lifestyle influences. This study contributes to understanding the factors affecting CHC treatment outcomes and supports the optimization of therapeutic strategies in similar healthcare contexts.
Arailym Maikenova - Asfendiyarov Kazakh National Medical University, Institute of Gastroenterology, Hepatology and Metabolism "Interna Clinic", Almaty, Republic of Kazakhstan phone: +77751761754, e-mail: a.maikenovaa@gmail.com, https://orcid.org/0000-0003-4658-2272.
Alexander Nersesov - Doctor of Medical Sciences, Professor, Head of the department of gastroenterology Kazakh National Medical University named after S.Zh. Asfendiyarov, Institute of Gastroenterology, Hepatology and Metabolism "Interna Clinic", Almaty, the Republic of Kazakhstan, phone: +77017998212, e-mail alexander.nersesov@gmail.com, https://orcid.org/0000-0002-8601-3966
Aigul Raissova - сandidate of Medical Sciences, department of Gastroenterology, Kazakh National Medical University named after S.Zh. Asfendiyarov, Institute of Gastroenterology, Hepatology and Metabolism "Interna Clinic", Almaty, Republic of Kazakhstan, phone: . e-mail: ram-79@mail.ru, https://orcid.org/0000-0001-5115-8922
Elmira Kuantay - Hepatological Center of Almaty, Institute of Gastroenterology, Hepatology and Metabolism "Interna Clinic", Almaty, Republic of Kazakhstan, phone:+77016322903 . e-mail: Kuantai_elmira@mail.com
Mukhtar Kulimbet- Asfendiyarov Kazakh National Medical University, Almaty, Republic of Kazakhstan, phone: +77079165387. e-mail: mkbkul@gmail.com
Aliya Balabek - Hepatological Center of Almaty, Republic of Kazakhstan, phone: +77474276626. e-mail: Ali.nur89@inbox.ru
Nugmanova Balzhan - Hepatological Center of Almaty, Republic of Kazakhstan, phone:+77762019955. e-mail: b.t.nugmanova@mail.ru
Venera Ayupova - Hepatological Center of Almaty, Republic of Kazakhstan, phone: +77017154220. e-mail: Venera25_84@mail.ru
Aisulu Gainutdin - Asfendiyarov Kazakh National Medical University, Hepatology and Metabolism "Interna Clinic", Almaty, Republic of Kazakhstan, phone: +77473387471. e-mail: aisulu_gainutdin@mail.ru
Madina Kakimova - Asfendiyarov Kazakh National Medical University, Hepatology and Metabolism "Interna Clinic", Almaty, Republic of Kazakhstan, phone: +77776668198 . e-mail: mkakimova55@gmai.com
Malika Aznabakiyeva - Asfendiyarov Kazakh National Medical University, Hepatology and Metabolism "Interna Clinic", Almaty, Republic of Kazakhstan, phone: +77076477137 . e-mail: Abazika_99mail.ru
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Maikenova A., Nersesov A., Raissova A., Kuantay E., Kulimbet M., Balabek A., Nugmanova B., Ayupova V., Gainutdin A., Kakimova M., Aznabakiyeva M. Predictors of antiviral therapy ineffectiveness in chronic hepatitis C: a matched case-control study in Almaty, a major metropolis of Kazakhstan // Nauka i Zdravookhranenie [Science & Healthcare]. 2025. Vol.27 (2), pp. 15-20. doi 10.34689/SH.2025.27.2.002Похожие публикации:
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