CLINICAL SIGNIFICANCE OF SERUM KLOTHO LEVELS IN PATIENTS WITH STEMI AND RENAL DYSFUNCTION
Introduction: Renal dysfunction is recognized as a major global public health issue, with an estimated worldwide prevalence of up to 13.4%. Patients with renal dysfunction represent a growing proportion of the PCI population. At the same time, patients with chronic kidney disease are at high risk of adverse cardiovascular events.
Objective: To evaluate the relationship between the Klotho protein and traditional cardiovascular risk markers in patients with ST-segment elevation myocardial infarction (STEMI) combined with renal dysfunction.
Materials and Methods:
Design: Cross-sectional clinical study.
Timeline: 2022–2023.
Location: The department of Cardiac surgery of the hospital at NJSC “Medical University of Semey.”
The study methods included evaluation of residual platelet reactivity and measurement of serum Klotho protein levels.
Results: A total of 123 patients were included. An inverse correlation was found between age and Klotho protein level (Rho = –0.673; p < 0.001). A direct correlation was found between estimated glomerular filtration rate (GFR) and serum Klotho (Rho = 0.463; p < 0.001). Additionally, for the first time, a correlation between Klotho and total cholesterol (Rho = –0.417; p < 0.001) and C-reactive protein (Rho = –0.416; p < 0.01) was demonstrated.
Conclusion: In patients with ST-segment elevation myocardial infarction (STEMI) and GFR < 60 mL/min/1.73 m², assessment of serum Klotho levels may serve as an early and independent biomarker of renal dysfunction and a predictor of adverse cardiovascular outcomes.
Aisulu S. Zhunuspekova - PhD, Acting Associate Professor of the Department of Therapy of the NAO "Semey Medical University", Postal address: 071400, Republic of Kazakhstan, Abai region, Semey, Abai Kunanbayeva str., 103, https://orcid.org/0000-0002-2413-317Х , e-mail: aisulu.zhunuspekova@smu.edu.kz ; Phone number: +7 771 840 5880,
Lyudmila K. Karazhanova - Doctor of Medical Sciences, Professor of the Department of Therapy of the NAO "Semey Medical University", Postal address: 103 Abai Kunanbayev str., Semey, 071400, Republic of Kazakhstan, Abay region, https://orcid.org/0000-0002-4719-6034, e-mail: kar_ludmila@bk.ru; Phone number: +7 701 355 9976,
Jamilya A. Mansurova - PhD, Associate Professor, Head of the Department of Therapy at the NAO "Semey Medical University", Postal address: 103 Abai Kunanbayeva str., Semey, 071400, Republic of Kazakhstan, Abay region, Semey, https://orcid.org/0000-0003-2439-2056, e-mail: mansurova_dzhami@mail.ru; Phone number: +7 777 330 5104,
Andrey Yu. Orekhov - PhD, Assistant Professor at the Department of Therapy of the NAO "Semey Medical University", Postal address: 103 Abai Kunanbayeva str., Semey, 071400, Republic of Kazakhstan, Abay region, Semey, https://orcid.org/0000-0001-7201-1399, e-mail: orekhov-andrei@list.ru ; Phone number: +7 777 414 1476,
Merkhat N. Akkaliyev - PhD, Acting Associate Professor of the Department of Surgical Disciplines, NAO "Semey Medical University", Republic of Kazakhstan; https://orcid.org/0000-0003-3122-7411, Postal address: 071400, Republic of Kazakhstan, Abai region, Semey, Abai Kunanbayev str., 103, e-mail: merhat.akkaliev@smu.edu.kz ; Phone number: +7 777 153 9854
Anar D. Kozhabayeva- PhD, Doctoral student at the Department of Therapy of the NAO "Semey Medical University", Postal address: 103 Abai Kunanbayev str., Semey, 071400, Republic of Kazakhstan, Abay region, https://orcid.org/0000-0003-4132-6755, e-mail:anik97.kz@bk.ru; Phone number: +7 705 817 9617,
Mirgul A. Kapakova - Candidate of Medical Sciences, Head of the Department of Therapy at the NAO "Semey Medical University", Postal address: 103 Abai Kunanbayev str., Semey, 071400, Republic of Kazakhstan, Abay region, https://orcid.org/0000-0003-4186-8933, e-mail: kma_mira@mail.ru; Phone number: +7 777 278 9724,
Gulraushan S. Satieva – Deputy Chief Physician, HR expert of the Pobeda Institution, Postal address: 071400, Republic of Kazakhstan, Abad region, Semey, Pobedy St. 18, e-mail: vika-1955@mail.ru; Phone number: +7 701 442 0658
Bolat A. Ashirov - Candidate of Medical Sciences, South Kazakhstan Medical Academy, Republic of Kazakhstan, https://orcid.org/0000-0003-0242-9700, e-mail: bolat.baja@mail.
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Zhunuspekova A.S., Karazhanova L.K., Mansurova J.A., Orekhov A.Y., Akkaliyev M..N., Kozhabayeva A.D, Kapakova М.A, Satieva G.S., Ashirov B.A. Clinical Significance of Serum Klotho Levels in Patients with STEMI and Renal Dysfunction // Nauka i Zdravookhranenie [Science & Healthcare]. 2025. Vol.27 (2), pp. 62-69. doi 10.34689/SH.2025.27.2.008Похожие публикации:
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