EFFICACY OF PHOTODYNAMIC THERAPY IN THE TREATMENT OF CERVICAL PRECANCEROUS CONDITIONS CAUSED BY HUMAN PAPILLOMAVIRUS
Relevance: PDT is a high-tech treatment that uses a combination of a photosensitizer, light and molecular oxygen. The method is based on the mechanisms of free radical oxidation, disruption of the vascular stroma of tumors and elimination under the influence of immune cells. It is a non-invasive, effective and safe treatment that damages and destroys structures in the affected area. However, to normalize the immune response, ensuring a stable regression of carcinogenesis, prolonged elimination of HPV is necessary.
Aim: to assess the status of various levels of tissue damage in cervical dysplasia in combination with PVI, using PDT as the main method of treatment.
Search strategy: In this study, indicators of the state of the organ, tissue, cellular and molecular levels are used to assess the course of PVI of the cervix. The role of the immune response in HPV-associated precancerous diseases of the cervix is considered. The article presents work on the treatment of dysplasia of varying degrees associated with HPV in 92 patients over a two-year period using PDT.
Results: The use of photodynamic therapy in women with HPV-associated cervical precancerous disease is a promising area of research. The results of the work link the role of TLRs with the development of squamous intraepithelial lesions (SIL). Further clinical studies are needed to evaluate efficacy, safety and optimal timing.
Akmarаl Eskeldikyzy Khangeldi – Obstetrician-Gynecologist, PhD student in Medicine, NCJSC «Astana Medical University», Phone: +7(707)712-00-93, Е-mail: akhangeldi@mail.ru, ORCID: https://orcid.org/0000-0003-0603-1230, 49A Beibitshilik Avenue, Astana, Republic of Kazakhstan;
Zaytuna Gadilovna Khamidullina - PhD, Candidate of Medical Sciences, Head of the Department of Obstetrics and Gynecology No. 1, NCJSC "Astana Medical University", Phone: +7(777)153-65-84, E-mail: 59@gmail.com, ORCID: https://orcid.org/0000-0002-5324-8486, 9/4 Kabanbay Batyr Street, Astana, Republic of Kazakhstan;
Nasrulla Abdullayevich Shanazarov - Doctor of Medical Sciences, Professor, Chief Oncologist, RSE "Hospital of the Medical Center of the Administrative Department of the President of the Republic of Kazakhstan" on the right of economic management, Phone: +7(777)079-13-07, E-mail: nasrulla@inbox.ru, ORCID: https://orcid.org/0000-0002-2976-259X, 2 Y495 Street, Astana, Republic of Kazakhstan;
Maxim Stanislavovich Afanasyev - Doctor of Medical Sciences, Professor of the Department of Clinical Immunology and Allergology, N.V. Sklifosovsky Institute of Clinical Medicine, Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Phone: +7(913)685-52-38, E-mail: maxim.afanasyev78@gmail.com, ORCID: https://orcid.org/0000-0002-5860-4152, 3 Bolshaya Sukharevskaya Square, Moscow, Russian Federation;
Tatyana Georgievna Grishacheva - PhD (Biology), Senior Researcher, Center for Laser Medicine, Pavlov First Saint Petersburg State Medical University, Phone: +7(911)220-38-90, E-mail: grishatanchik82@gmail.com, ORCID: https://orcid.org/0000-0002-9515-914X, 6/8 Lva Tolstogo Street, St. Petersburg, Russian Federation;
Nagima Nurlanovna Akkazhiyeva - Obstetrician-Gynecologist, Municipal State Enterprise on the Right of Economic Management "City Multidisciplinary Hospital No. 2", Phone: +7(701)609-73-27, E-mail: Akk.n.n@mail.ru, ORCID: https://orcid.org/0000-0003-1571-6960, 8 Ryskulov Street, Astana, Republic of Kazakhstan;
Tanysheva Gulyash Altyngazinovna - Candidate of Medical Sciences, Head of the Department of Obstetrics and Gynecology, NCJSC «Semey Medical University», phone 8(777)153-53-57, email gulyash1965@mail.ru, https://orcid.org/0000-0001-9531-5950, 103 Abay Street, Semey, Kazakhstan.
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Khangeldi A.Yе., Khamidullina Z.G., Shanazarov N.A., Afanasyev M.S., Grishache T.G., Akkazhiyeva N.N., Tanysheva G.A. Efficacy of Photodynamic Therapy in the Treatment of Cervical Precancerous Conditions Caused by Human Papillomavirus // Nauka i Zdravookhranenie [Science & Healthcare]. 2025. Vol.27 (3), pp. 53-63. doi 10.34689/SH.2025.27.3.006Похожие публикации:
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