CLINICAL SIGNIFICANCE OF SERUM KLOTHO LEVELS IN PATIENTS WITH STEMI AND RENAL DYSFUNCTION
Introduction: Renal dysfunction is recognized as a major global public health issue, with an estimated worldwide prevalence of up to 13.4%. Patients with renal dysfunction represent a growing proportion of the PCI population. At the same time, patients with chronic kidney disease are at high risk of adverse cardiovascular events.
Objective: To evaluate the relationship between the Klotho protein and traditional cardiovascular risk markers in patients with ST-segment elevation myocardial infarction (STEMI) combined with renal dysfunction.
Materials and Methods:
Design: Cross-sectional clinical study.
Timeline: 2022–2023.
Location: The department of Cardiac surgery of the hospital at NJSC “Medical University of Semey.”
The study methods included evaluation of residual platelet reactivity and measurement of serum Klotho protein levels.
Results: A total of 123 patients were included. An inverse correlation was found between age and Klotho protein level (Rho = –0.673; p < 0.001). A direct correlation was found between estimated glomerular filtration rate (GFR) and serum Klotho (Rho = 0.463; p < 0.001). Additionally, for the first time, a correlation between Klotho and total cholesterol (Rho = –0.417; p < 0.001) and C-reactive protein (Rho = –0.416; p < 0.01) was demonstrated.
Conclusion: In patients with ST-segment elevation myocardial infarction (STEMI) and GFR < 60 mL/min/1.73 m², assessment of serum Klotho levels may serve as an early and independent biomarker of renal dysfunction and a predictor of adverse cardiovascular outcomes.
Количество просмотров: 799
Категория статей:
Оригинальное исследование
Библиографическая ссылка
Zhunuspekova A.S., Karazhanova L.K., Mansurova J.A., Orekhov A.Y., Akkaliyev M..N., Kozhabayeva A.D, Kapakova М.A, Satieva G.S., Ashirov B.A. Clinical Significance of Serum Klotho Levels in Patients with STEMI and Renal Dysfunction // Nauka i Zdravookhranenie [Science & Healthcare]. 2025. Vol.27 (2), pp. 62-69. doi 10.34689/SH.2025.27.2.008Похожие публикации:
REPROGRAMMING EXPERIENCE OF BLOOD MONONUCLEAR CELLS INTO INDUCED PLURIPOTENT STEM CELLS (IPSCS) IN A PATIENT WITH CATECHOLAMINERGIC POLYMORPHIC VENTRICULAR TACHYCARDIA (CPVT)
CREATION OF THE PREGNANCY MICE MODEL TO STUDY THE EFFECT OF GLP-1/GIP AGONISTS
SATISFACTION WITH THE QUALITY OF PRIMARY CARE FOR PATIENTS WITH HYPERTENSION
EPIDEMIOLOGY, RESOURCE DISTRIBUTION, AND MANAGEMENT CHALLENGES OF CHRONIC HEART FAILURE IN KAZAKHSTAN: A NATIONAL RETROSPECTIVE ANALYSIS
PREVALENCE OF POLYMORPHISMS IN WARFARIN METABOLISM-RELATED GENES AMONG THE KAZAKH POPULATION