CLINICAL EFFICACY OF SELECTIVE PLASMA FILTRATION (EVACLIO) IN CARDIOVASCULAR COMPLICATIONS: A CASE SERIES FROM THE HEART CENTER KAZAKHSTAN
Background: Cardiovascular surgical patients with sepsis and hepatic dysfunction present significant perioperative management challenges. Selective plasma filtration using the Evaclio system has emerged as a novel extracorporeal therapy for the removal of inflammatory mediators and bilirubin. This is the first case series from Kazakhstan reporting the use of Evaclio in a cardiothoracic setting.
Materials and methods: This retrospective case series describes 15 patients (mean age: 56±3,65 years) who underwent open-heart surgery at the CF UMC “Heart Center” between 2023 and 2024 and subsequently developed sepsis and/or hyperbilirubinemia indicative of acute hepatic dysfunction. All patients received selective plasma filtration using the Evaclio system as part of their post-operative critical care. Statistical data processing was performed using IBM SPSS 29.0. Descriptive statistics, Wilcoxon test and Spearman correlation test were used. Values of p < 0.05 were considered statistically significant.
Results: This retrospective cohort study was conducted at the CF UMC “Heart Center” in Astana, Kazakhstan, from January 2023 to December 2024. The study included 15 patients who underwent heart defect correction with cardiopulmonary bypass (CPB). The use of the Evaclio filter was associated with a significant reduction in ALT, AST levels (p < 0.01), and platelets (p < 0.05), reflecting a decrease in inflammatory response and cytolysis. A positive trend in bilirubin and uremic markers was observed, and in some patients (up to 40%), a reduction in bilirubin of ≥ 30% was achieved, indicating the potential effectiveness of the method as part of comprehensive sepsis therapy.
Conclusion: Evaclio selective plasma filtration demonstrated promising results in managing postoperative sepsis and hepatic dysfunction in pediatric cardiac surgery patients. Its use may offer an effective adjunct to conventional intensive care in similar settings. Further prospective studies are needed to validate these findings.
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Amanzholova A.K., Koichubayeva D.K., Zuparov Y.N., Serikova A.A., Abilbayeva A.А., Bekishev B.E. Clinical Efficacy of Selective Plasma Filtration (Evaclio) in Cardiovascular Complications: A Case Series from the Heart Center Kazakhstan // Nauka i Zdravookhranenie [Science & Healthcare]. 2025. Vol.27 (6), pp. 38-45. doi 10.34689/SH.2025.27.6.005Похожие публикации:
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CLINICAL EFFICACY OF SELECTIVE PLASMA FILTRATION (EVACLIO) IN CARDIOVASCULAR COMPLICATIONS: A CASE SERIES FROM THE HEART CENTER KAZAKHSTAN