THE EFFECT OF PRECONCEPTION CARE ON PERINATAL OUTCOMES OF THE MOTHER-PLACENTA-FETUS SYSTEM
Relevance. Examining the placenta could provide valuable insights into the effectiveness of preconception care, inform pregnancy management strategies, and aid in planning future pregnancies.
Objective: comparative clinical and morphological characteristics of the "mother-patient-fetus" system in women with preconception care and women without preconception care.
Methods. A prospective study compared maternal, perinatal and placental outcomes in a group of women who received preconception 6 months prior to their current pregnancy and women who did not receive preconception prior to their current pregnancy, provided that they also had placental histology. Clinical data were obtained from the medical records of the mother and newborn in a comprehensive health information system. The examination of the placenta and the collection of placental tissue fragments were carried out in accordance with the consensus recommendations of the Amsterdam Placental Workshop Group.
Results. Women with preconception care suffered less from serious pregnancy complications, such as Preeclampsia (4.3% vs. 11.6%; p=0.015) or gestational hypertension (7.9% vs. 15.2%; p=0.039). In the group of newborns from women with preconception care, young children for gestational age are less common (10.4% vs. 19.5%; p=0.021), newborns have fewer respiratory complications (14.0% vs. 23.8%; p=0.025) and antenatal fetal mortality (0.6% vs. 6.1%; p=0.006). Histopathological results of maternal vascular malperfusion (12.8% vs. 29.9%; p<0.01), acute inflammation of the placenta (4.9% vs. 11.6%; p=0.028) and chronic inflammation of the placenta (5.5% vs. 12.8%; p=0.022) are rare in the placentas of women with preconception care, as well as macrophages are rare. chorial with meconium in the lamina and amniotic membranes (7.9% vs. 16.5%; p=0.019).
Conclusion. Preconception care, aimed at improving the health of the mother, leads to a decrease in histopathological findings in the placentas and an improvement in the perinatal outcome. Morphological examination of the placenta should be an integral part of the strategy aimed at mitigating the adverse outcomes of current and subsequent pregnancy and childbirth in women without preconception care.
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Podilyakina Y., Stabayeva L., Kulov D., Kamyshanskiy Ye., Amirbekova Zh., Stundžienė R., Zhamantayev O., Nukeshtaeva K. The effect of preconception care on perinatal outcomes of the mother-placenta-fetus system // Nauka i Zdravookhranenie [Science & Healthcare]. 2025. Vol.27 (6), pp. 67-76. doi 10.34689/SH.2025.27.6.008Похожие публикации:
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