FACTORS OF LIMITED DIAGNOSIS OF PHARAMACORESISTANT EPILEPSY
Background: Drug-resistant epilepsy (DRE) remains a serious clinical challenge, especially in settings with limited access to specialized care. A significant proportion of patients in Kazakhstan do not receive timely diagnosis or referral to specialized centers.
Objective: The aim of this study is to identify, using the example of the Epilepsy center’s work, the barriers that limit access to specialized treatment, particularly the timely establishment of a diagnosis of drug-resistant epilepsy.
Materials and methods: This retrospective observational study included 560 Kazakh patients with DRE who presented to the Center between 2017 and 2023. Clinical and demographic data, social status, place of residence, and access to specialized care were analyzed. Statistical processing was performed using non-parametric methods and the χ² test, with a significance level of p < 0.05.
Results: In the overall patient group, delayed identification of drug resistance was associated with marital status and region of residence. Among patients whose diagnosis was first established at the Epilepsy center, unmarried individuals predominated (p < 0.006). A statistically significant predominance of individuals from Astana who received specialized care was observed (p < 0.0001). Examination of the association between DRE diagnosis and different epilepsy duration groups revealed no significant relationship in any group. Analysis of factors contributing to delayed DRE diagnosis in patients with disease duration over 20 years showed that men were almost 1.5 times more likely to experience delayed diagnosis compared to women (OR, 95% CI: 1.12 (1.02–1.31), p = 0.02), and lack of social protection reduced the likelihood of receiving specialized care (OR, 95% CI: 0.65 (0.54–0.79), p < 0.0001).
Conclusions: Timeliness of DRE diagnosis in Kazakhstan is determined by a combination of sociodemographic and regional factors. Patients from Astana and those with social support have better access to specialized care. Systemic measures are needed to improve patient referral pathways, reduce regional disparities, and combat stigmatization.
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Suleimenova A., Bekenova N., Vochshenkova T., Kassiyeva B., Aitkaliyev A., Belikhina T., Utebekov Zh., Dossov M., Factors of limited diagnosis of pharamacoresistant epilepsy // Nauka i Zdravookhranenie [Science & Healthcare]. 2025. Vol.27 (6), pp. 101-108. doi 10.34689/SH.2025.27.6.012Похожие публикации:
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