LONG-TERM RESULTS AND QUALITY OF LIFE AFTER SURGICAL TREATMENT OF DIFFUSE TOXIC GOITER
This study is devoted to improving the results of surgical treatment of patients with diffuse toxic goiter by justifying the choice of thyroid residue volume and predicting thyroid status in the long term. The work is based on the study of the long-term results of surgical treatment of 90 patients suffering from diffuse toxic goiter.
Aim: to study the long-term results of surgical treatment of CTD based on quality of life (QOL) and determination of the optimal amount of surgical intervention.
Materials and methods of research: From 2013 to September 2024, 90 patients with diffuse toxic goiter were operated in the surgical department of the University Hospital NСJSC «Semey Medical University».
All patients were divided into 2 groups: I — the main group, which included 63 patients who underwent subtotal subfascial resection of the thyroid gland (PCF) with the removal of thyroid tissue, II — the control group, in which 27 patients underwent thyroidectomy (TE).
There were 78 (86.6%) women and 12 (13.4%) men among the patients. The age of the patients ranged from 20 to 69 years and averaged 41.9±10.58 years. In 46 cases, accounting for 51.1% of all patients, DTT was combined with endocrine ophthalmopathy (EOP)
Results: Based on a clinical and hormonal examination conducted between 3 and 11 years after breast cancer (group I), it was found that 4 (4.7%) patients developed a recurrence of thyrotoxicosis, 65 (76.5%) patients developed hypothyroidism, and only 16 (18.8%) patients retained their euthyroid state. Hypothyroidism was achieved in all 40 patients after TE.
We did not find an effect of the age, gender of patients, average duration of the disease, severity of thyrotoxicosis, hormonal parameters (T3, T4, TSH), antibody titer to thyroid peroxidase (AT to TPO) before surgery, as well as the morphological structure of thyroid tissue on the long-term results of surgical treatment of DTP.
There were no fatal outcomes among the patients of both the main and control groups.
Conclusions: With an equal thyroid balance, different outcomes of subtotal thyroid resection are possible: hypothyroidism (76.5%), euthyroidism (18.8%) and thyrotoxicosis recurrence (4.7%). The main factors that increase the likelihood of recurrence of diffuse toxic goiter after subtotal resection of the thyroid gland are: preoperative antibody levels to the thyroid-stimulating hormone receptor of more than 30 U / l, combination of DTT with endocrine ophthalmopathy.
The quality of life of DTT patients 6 months after surgical treatment does not significantly differ in many indicators from the quality of life of healthy people.
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Omarov N.B., Aimagambetov M.Zh., Dyussupov A.A., Mukash Ye.A., Bulegenov T.А., Abdrakhmanov S.T., Auyenov M.A., Zharikov A.N. Long-term results and quality of life after surgical treatment of diffuse toxic goiter // Nauka i Zdravookhranenie [Science & Healthcare]. 2025. Vol.27 (6), pp. 126-134. doi 10.34689/SH.2025.27.6.015Похожие публикации:
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