ГЕОГРАФИЧЕСКОЕ РАСПРЕДЕЛЕНИЕ ГЕНОТИПОВ ВИРУСА ГЕПАТИТА В И СВЯЗЬ С КЛИНИЧЕСКИМИ ПРОЯВЛЕНИЯМИ ХРОНИЧЕСКОГО ВИРУСНОГО ГЕПАТИТА В: ОБЗОР ЛИТЕРАТУРЫ
Актуальность. Хронический вирусный гепатит Впредставляет собой глобальную проблему для общественного здравоохраненияво всем мире из-за высоких показателей инфицированности (более 250 млн. человек) исмертности (около 2 млн. человек). На прогрессирование и клинические исходы заболеваниявлияют множество факторов, начиная от биологических свойств вируса до генетических факторов.
Цель. Анализ литературных источников, посвященных изучению распространенности генотипов и их влияния на клиническое течение хронического вирусного гепатита В.
Стратегия поиска. Проведен поиск научных публикаций в поисковых системах PubMed, GoogleScholar, GoogleAcademia, в электронной научной библиотеке eLibrary.ru, CyberLeninka. Критерии включения: глубина поиска составила 15 лет (2004-2019); публикации на казахском, русском и английском языках; полнотекстовые эпидемиологические и клинические исследования. Критерии исключения: исследования, проведенные на животных, повторно встречающиеся публикации, исследования, связанные с изучением генотипов при вирусном гепатите С, с ответом на противирусную терапию, материалы конференций и клинические случаи.
Результаты.Генотип D наиболее часто встречается и имеет повсеместное распространение. Генотипы А, В, С имеют характерное географическое распределение в Европе, странах Африканского контингента (генотип А) и Азии, в частности в Китае (генотип В) и Корее (генотип С). С благоприятным прогнозом чаще связан генотип В, в то время как неблагоприятное течение заболевания ассоциируется с С генотипом.
Выводы.Таким образом, генотипы имеют характерное географическое расспределение и влияют на клиническое течение и исходы хронического вирусного гепатита В.
Айнур К. Кумарбекова1, Имдат М. Эфендиев1, Лидия А. Муковозова1
1 НАО «Медицинский университет Семей»,
г. Семей, Республика Казахстан
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Кумарбекова А.К., Эфендиев И.М., Муковозова Л.А. Географическое распределение генотипов вируса гепатита В и связь с клиническими проявлениями хронического вирусного гепатита В: обзор литературы // Наука и Здравоохранение. 2019. 6 (Т.21). С. 11-23.Похожие публикации:
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