IMMUNOPATHOGENETIC BASES OF SEVERITY OF COVID-19. LITERATURE REVIEW
Relevance. The outbreak of COVID-19 began in late 2019 in Hubei Province, China. Already in the first quarter of 2020, the disease spread around the world. On March 11, 2020, WHO declared a COVID-19 pandemic. The first cases of the disease in Kazakhstan were registered in March 2020.
The aim of the study: a systematic search for scientific information about the socially significant disease COVID-19 and its immunopathogenetic basis for the severity of the course.
Search strategy: Research publications were searched in PubMed, ResearchGate, GoogleScholar databases. A total of 325 literary sources were found, of which 89 were selected for analysis.
Results: To date, clinical experience suggests a wide range of clinical manifestations of COVID-19 from asymptomatic to severe disease with poor survival associated with an aggressive inflammatory response. There is clinical evidence that suggests that cytokine storm is associated with the severity of COVID-19 and is also the leading cause of death. Hyperactivation of the immune system during COVID-19 leads to a sharp increase in the levels of pro-inflammatory cytokines - a cytokine storm that is characterized by systemic inflammation, hyperferritinemia, acute respiratory distress syndrome, systemic inflammatory response syndrome, hemodynamic disturbances, thrombosis, disseminated intravascular coagulation, lung damage and others. organs, multiple organ failure with a poor prognosis.
Conclusion. The cytokine storm caused by SARS-CoV-2 infection is a central mediator of lung damage and, as a result, can cause life-threatening complications. We present several leukocyte and cytokine changes that may help determine the progression and severity of COVID-19 from early to advanced in both mild and severe cases.
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Yessenbayeva A.A., Mussazhanova Zh.B., Kazymov M.S., Apsalikov B.A., Saidualiev D.N., Shalgumbayeva G.M., Kozykenova Zh.U., Krykpayeva A.S., Khamitova M.O., Massabayeva M.R. Immunopathogenetic bases of severity of COVID-19. Literature review // Nauka i Zdravookhranenie [Science & Healthcare]. 2022, (Vol.24) 2, pp. 93-102. doi 10.34689/SH.2022.24.2.012Похожие публикации:
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