THE ROLE OF THE INTESTINAL MICROBIOTA IN THE DEVELOPMENT OF AUTOIMMUNE RHEUMATIC DISEASES
Introduction: The gut microbiota plays an important role in developing rheumatoid arthritis (RA), ankylosing spondylitis (AS), psoriatic arthritis (PsA), juvenile idiopathic arthritis (JIA) and others rheumatic diseases. Its studies promote new opportunities for improving the early diagnosis, and possibly the prevention of severe autoimmune rheumatic diseases, as well as correcting the tactics of a personalized approach to treatment.
Aim: This review evaluates the relevant information on the relationship between changes in the microbiota and the development of rheumatic diseases in children and adults.
Search strategy: Literature search was carried out using PubMed (Medline), Scopus databases, eLibrary.ru, Google Scholar by keywords: “gut microbiome”, “microbiota”, “rheumatoid arthritis”, “rheumatic diseases”, “spondyloarthropathies”. The search depth is 20 years (2000-2021). The original language is English. Inclusion criteria: reports of randomized and cohort studies conducted on large populations, meta-analyses and systematic reviews. Exclusion criteria: articles describing single cases, series of cases, as well as experimental work on animals. Out of 113 literary sources, 78 were selected as analytical material for this article.
Summary: Analysis of the sources showed that the conducted studies revealed deviations in the diversity of intestinal microflora in patients with rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis. The main attention was paid to cataloging the microorganisms present, identifying the relationship between microbial species and diseases. Differences in the composition of the microbiota in children and adults have been established. Currently, the relationship of various factors, such as gender, age, race, living conditions, geographical location, remains not completely explored. However, there are no long-term studies with the collection of samples of the intestinal microbiome in several time intervals: before and after the appointment of basic anti-inflammatory therapy, against the background of ineffective therapy, as well as tracking the relationship with the nature of the course, the activity of the disease or the intensity of symptoms.
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Petrova Yu.V., Ivanova R.L., Tugelbayeva A.M., Zonova E.V., Lobanov Yu. F., Goremykina М.V. The role of the intestinal microbiota in the development of autoimmune rheumatic diseases // Nauka i Zdravookhranenie [Science & Healthcare]. 2022, (Vol.24) 4, pp. 137-145. doi 10.34689/SH.2022.24.4.018Похожие публикации:
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