METHODS OF DETERMINING THE LOCOMOTOR ACTIVITY OF RATS
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Introduction: studying locomotor activity of rat used in experimental research in worldwide. This is due to the fact that it is an integral part of clinical trials. With the definition of mobility, we can evaluate the effect of certain pharmacological agents, environmental influences on psycho-emotional state of a living organism. The article presents the literature review on the various techniques of determining the locomotor activity of mammals as well as our personal development about studying the mobility of rats. Aim: to develop a method for twenty-four-hour observation of the locomotor activity of rats. Materials and methods: to achieve this aim an experiment was conducted on sixteen white laboratory «Wistar’s» rats, as well as the analysis of systematic search of research papers. Results: the proposed method allows us to record the locomotor activity of mammal almost around the clock, except only one hour, which is necessary to clean the box and feeding. The method consists in the use of «Activity Sensor» apparatus. It is a sensor, has infrared rays which determined the activity of rats. Data were recorded on a computer which has been connected to the device. Conclusion: determination of the level of activity living organism - considered one of the necessary steps in the epidemiological and experimental studies. Because only use this method we can evaluate how condition influence on the psycho-emotional state on it.
Aisulu Zh. Saimova ¹, http//orcid.org/0000-0002-9564-732X Кassym Sh. Zhumadilov 2, http://orcid.org/0000-0002-0205-4585 Nailya Zh. Chaizhunusоva 1, httр://оrcid.оrg/0000–0002–6660–7118 Ynkar O. Kairkhanova ¹, httр://оrcid.оrg/0000–0001–9533–1723 Darkhan Е. Uzbеkоv ¹, httр://оrcid.оrg/0000–0003–4399–460X Valеriy F. Stерanеnkо 3, http://orcid.org/0000-0002-3541-0515 Tоlеbay K. Rаkhyрbеkоv 1, httр://оrcid.оrg/0000–0002–5699–3086 Masaharu Hоshi 4, httр://оrcid.оrg/0000–0001–6978–0883 1 Semey State Medical University, Semey. Kazakhstan; 2 International Department of Nuclear Physics, New Materials and Technology, L.N. Gumilyov Eurasian National University, Astana, Kazakhstan; 3 A. Tsyb Medical Radiological Research Center (MRRC) – National Medical Research Radiological Center Ministry of Health of Russian Federation, Obninsk, Russia; 4 Hiroshima University, Hiroshima Japan.
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