Introduction: Hyperinsulinemia can occur at any age and is a known major factor in metabolic disease and may increase the chance of developing a number of functional or pathological conditions and diseases. Decreased insulin sensitivity primarily affects the liver, muscles, and adipose tissue. Insulin resistance develops several years before the onset of type 2 diabetes mellitus, it is associated with obesity, abdominal obesity, but can also occur in lean people with hypertension. The aim: To study the frequency of hyperinsulinemia in the Kazakh population. Materials and methods: One-stage cross-sectional study. A survey of 342 representatives of the Kazakh nationality aged 18-65 was conducted. The inclusion criteria were healthy males and females aged 18 to 65 years of the Kazakh population. The exclusion criteria included patients with malignant neoplasms; having heart and / or kidney failure in the decompensated stage; pregnancy; lactation. The object of the study are healthy representatives of the Kazakh population in different age groups that meet the inclusion criteria. Results: In our study, abdominal obesity is more common in Kazakh women than in men. Hyperinsulinemia was more common in people who consumed alcohol. The chance of developing hyperinsulinemia increased by 2.3 times (95% CI: 0.99-5.41) in individuals who drink alcohol compared to those who do not drink alcohol. In our study, insulin levels were not associated with gender, BMI, waist circumference, smoking, or exercise. Age had a significant correlation with BMI and waist circumference (rs=0.7; p=0.0001). Conclusions: Thus, it can be assumed that alcohol consumption may contribute to the development of hyperinsulinemia.
Aizhan Т. Shakhanova1, http://orcid.org/0000-0001-8214-8575 Zauresh K. Zhumadilova1, http://orcid.org/0000-0001-6211-6154 Alida Sh. Kaskabayeva1, http://orcid.org/0000-0002-5184-214X Madina R. Madiyeva1, https://orcid.org/0000-0001-6431-9713 Dina Zhambylova1, Karina Kazhmuratova1, Elmira Zhumasheva1, Diana Kairbekova1, Diana Bakibaeva1, Dana Kamadova1 1 NJSC "Semey Medical University", Semey city, Republic of Kazakhstan
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Shakhanova A.Т., Zhumadilova Z.K., Kaskabaeva A.Sh., Madieva M.R., Zhambylova D., Kazhmuratova K., Zhumasheva E., Kairbekova D., Bakibaeva D., Kamadova D. Evaluation of the frequency of hyperinsulinemia in representatives of the Kazakh nationality // Nauka i Zdravookhranenie [Science & Healthcare]. 2022, (Vol.24) 5, pp. 82-88. doi 10.34689/SH.2022.24.5.011

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