Online ISSN: 3007-0244,
Print ISSN:  2410-4280
THE USE OF PRP THERAPY IN OPTIMIZING WOUND HEALING AFTER HEMORRHOIDECTOMY
Relevance. Hemorrhoids are a disease with an exceptionally high prevalence, amounting to 140-160 per 1000 adult population (14-16%), whose share among colorectal diseases is more than 40%. To date, various methods of performing hemorrhoidectomy are known. This operation, regardless of the method used. it leads to the formation of open wounds of the anal canal, the healing time of which remains long, reaching 45 days. The aim of our research is to explore the effect of the use of PRP therapy in accelerated recovery and wound healing after hemorrhoidectomy. Materials and methods: We analyzed the results of a study of the treatment of patients with chronic hemorrhoids who were treated from January 2021 to January 2022, conducted on the basis of the surgical department of the RDC and MIPO Clinics LLP. The study included 100 patients aged 21 to 72 years with chronic hemorrhoids of stage II and III, in the treatment of which the method of hemorrhoidectomy with PRP therapy (main group) and open hemorrhoidectomy (control group) was used. In the analysis of clinical efficacy, the severity and duration of pain syndrome, manifestations of complications in the early postoperative period, cytomorphological analysis of fingerprint smears, the number of bed days spent and the period of recovery were used. An analysis of the assessment of the quality of life of patients after surgery in the long-term period was also carried out. Statistical processing of the results obtained in the course of the study was carried out by using the statistical software package R 3.4.4 for Windows using standard algorithms of variational statistics, as well as by using the SPSSv program 25 USA. Results: The intensity of pain severity was estimated at an average of 3±0.2 points in the main group and 6.1±0.3 points in the control comparison group. The duration of pain continuation after surgery averaged 3.1±0.2 days in the main group and 4.4± 0.2 days in the control comparison group. The development of early postoperative complications in the main group – in 6 (12%), in the control group were diagnosed in 14 (28%) cases. When assessing the dynamics of the wound process according to the cytological picture, it was noted that the neutrophil reaction was more pronounced in the control group. In the main group, epithelization elements appeared faster (from the 10th day - in 35%). The average epithelialization time was 31.1±2.2 days in the control group compared to 20.3±3.9 days in the main group. In the main group, by day 15, 31 (62%) patients and by day 25, 50 (100.0%) all patients returned to work. In the control group, 32 (64%) patients started working by day 30 and 100% by day 40. Conclusion: Taking into account the results of the study, the use of an integrated approach with the use of PRP therapy in the treatment of chronic hemorrhoids is recommended. It is shown that the use of the proposed patented treatment regimen leads to a decrease in postoperative pain syndrome, accelerated wound healing, and a decrease in the number of complications.
Dinara Nuspekova1, https://orcid.org/0000-0003-3577-907X Auyeskhan Dzhumabekov1, https://orcid.org/0000-0002-5817-8851 Aidos Doskaliev2, https://orcid.org/0000-0001-8727-567X Nurlan Kemelkhanov3, https://orcid.org/0000-0002-6382-8564 Adilbek Artykbayev1, https://orcid.org/0000-0003-4587-0969 1 Kazakhstan’s Medical University “Kazakhstan School of Public Health”, Almaty c., the Republic of Kazakhstan; 2 National Center for Neurosurgery, Astana c., Republic of Kazakhstan; 3Al-Farabi Kazakh National University, Almaty c., the Republic of Kazakhstan.
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Nuspekova D., Dzhumabekov A., Doskaliev A., Kemelkhanov N., Artykbayev A. The use of PRP therapy in optimizing wound healing after hemorrhoidectomy // Nauka i Zdravookhranenie [Science & Healthcare]. 2023, (Vol.25) 1, pp. 106-114. doi 10.34689/SH.2023.25.1.014

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