INVESTIGATION OF NPY AND FTO GENE POLYMORPHISM IN INDIVIDUALS WITH METABOLIC SYNDROME: LITERATURE REVIEW
Relevance. Conducting a comprehensive genetic study allows us to form a holistic picture of the genetic predictors of metabolic syndrome, which is considered important, since the priority area of modern healthcare is personalized medicine based on the identification of adequate genetic markers of the human body, which, in turn, determines the relevance of this study.
The purpose of the study: Conducting a literature review on the problem of polymorphisms of neuropeptide Y and FTO (fat mass and obesity associated) genes in patients with metabolic syndrome.
Research methods: During the literature review, 63 articles from the scientific databases Pubmed, Medline, Google Scholar, Embase, Web of Science published from 2018 to 2024 were analyzed. Keywords were used for the search: "metabolic syndrome", "polymorphism of the rs16147 gene (neuropeptide Y) in NPY", "Polymorphism of the FTO rs9939609 gene".
Results: In the course of research, scientists have proved that the polymorphism of the NPY rs16147 gene is associated with body weight, insulin resistance, serum adipokine levels and the risk of developing metabolic syndrome, obesity, diet, glucose and lipid metabolism and blood pressure indicators. Polymorphism of the FTO rs9939609 gene has shown in a study by scientists that obesity is an important genetic risk factor for the development of metabolic syndrome.
Conclusions: In the literature review, polymorphism of the FTO rs9939609 metabolic syndrome gene and its association with components were identified in populations of China, Vietnam, Brazil, Iran, Turkey, Arabs, Mexico and Poland. The dependence of polymorphism of the FTO rs9939609 gene on obesity and type 2 diabetes has been studied in Kazakhstan. Despite the fact that the polymorphism of the RS16147 NPY gene has been sufficiently studied in the world and the connection with metabolic syndrome and its components has been shown, the results of similar studies conducted in Kazakhstan have not been found in the literature available to us. Thus, the analysis of literature data confirms the need for a comprehensive genetic study to form a holistic vision of the genetic predictors of metabolic syndrome.
Нускабаева Гульназ Оразбековна - Қожа Ахмет Ясауи атындағы Халықаралық қазақ-түрік университеті, «Арнайы клиникалық пәндер» кафедрасының меңгерушісі, м.ғ.к., қауымдастырылған профессор; эл. почта: nuskabayeva.gulnaz@ayu.edu.kz; тел.: +77052853131; ORCID - 0000-0002-2906-1427
Садыкова Карлыгаш Жарылкасыновна - Қожа Ахмет Ясауи атындағы Халықаралық қазақ-түрік университеті, «Арнайы клиникалық пәндер» кафедрасының PhD, аға оқытушысы; эл. почта: karlygash.sadykova@ayu.edu.kz; тел.: +77077316476; ORCID - 0000-0002-9120-8565
Нұрдинов Нұрсұлтан Сейсенбайұлы - Қожа Ахмет Ясауи атындағы Халықаралық қазақ-түрік университеті, «Арнайы клиникалық пәндер» кафедрасының PhD, аға оқытушысы; эл. почта: nursultan.nurdinov@ayu.edu.kz; тел.: +77053787891; ORCID - 0000-0001-5341-7211
Анартаева Мария Уласбековна - «Оңтүстік Қазақстан медицина ақадемиясы» АҚ, Оқу-әдістемелік жұмыс жөніндегі проректор, медицина ғылымдарының докторы, доцент; эл. почта: mariya_anartayev@mail.ru; тел.: +77013794841; ORCID - 0000-0003-1087-6578
Сарсенбаева Гульзат Жанабаевна - «Оңтүстік Қазақстан медицина ақадемиясы» АҚ, «Әлеуметтік медициналық сақтандыру және қоғамдық денсаулық» кафедрасының меңгерушісі, м.ғ.к., қауымдастырылған профессор; эл. почта: gulsat.1969@mail.ru; тел.: +77017496288; ORCID - 0000-0002-1518-6528
Кемельбеков Канатжан Сауханбекович - «Оңтүстік Қазақстан медицина ақадемиясы» АҚ, «Педиатрия-1» кафедрасының меңгерушісі, PhD; эл. почта: kanat-270184@mail.ru; тел.: +77085334300; ORCID - 0009-0008-1619-6278
Сейдахметова Айзат Ашимхановна - «Оңтүстік Қазақстан медицина ақадемиясы» АҚ, «Шұғыл медицина және мейіргер ісі» кафедрасының меңгерушісі, м.ғ.к.; эл. почта: aizat-seidahmetova@mail.ru; тел.: +77017671448; ORCID - 0000-0002-5794-3814
Хат алмасуға жауапты автор:
Айдарбекова Дильбар Нургалиевна - Қожа Ахмет Ясауи атындағы Халықаралық қазақ-түрік университеті, «Арнайы клиникалық пәндер» кафедрасының магистр, аға оқытушысы; ORCID - 0009-0008-6845-032X
Почталық адрес: Түркістан облысы, Туркестан қ, Шымкент тас жолы көшесі, Каскад 10/3-9,
Е-mail: dilbar.aidarbekova@ayu.edu.kz
Телефон: +7 747 500 77 85.
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Aidarbekova D.N., Nuskabayeva G.O., Sadykova K.Zh., Nurdinov N.S., Anartayeva M.U., Sarsenbayeva G.Zh., Kemelbekov K.S., Seidakhmetova A.A. Investigation of NPY and FTO gene polymorphism in individuals with metabolic syndrome: literature review // Nauka i Zdravookhranenie [Science & Healthcare]. 2024. Vol.26 (6), pp. 184-195. doi 10.34689/SH.2024.26.6.021Related publications:
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