A CASE OF AUTOIMMUNE COMPLICATIONS FOLLOWING COVID-19 VACCINATION WITH SINOVAC-CORONAVAC (CHINA)
During the COVID-19 pandemic, vaccination in the Republic of Kazakhstan utilized the vaccine SinoVac-CoronaVac (China), which contains a chemically inactivated form of the SARS-CoV-2 virus and an adjuvant to stimulate immunity. A retrospective analysis was conducted on the medical history and observation of a patient, T., born in 1989, who developed overlap syndrome, rheumatoid arthritis, and systemic lupus erythematosus (SLE) after receiving the SinoVac-CoronaVac vaccine.
Blood analysis revealed leukopenia (2.8 × 10⁹), thrombocytopenia (104 units/µL), hypochromic anemia (hemoglobin 87 g/L), increased ESR, elevated rheumatoid factor (13.9), increased CRP (70.4), and elevated anti-streptolysin O (218 IU/mL). Antibodies to nuclear antigens (ANA) were also detected (32 units). The patient was treated with hormones, non-steroidal anti-inflammatory drugs, and rituximab.
This case suggests that COVID-19 vaccination with the SinoVac-CoronaVac vaccine activated the immune system and acted as a trigger for the development of autoimmune overlap syndrome. Recognizing the possibility of autoimmune complications enables better patient monitoring and care post-vaccination.
Nurgaliyeva Bayan – Doctor of Medical Sciences, MSP, Head of the Department of Propedeutics of Internal Diseases at NPJSC "Kazakh National Medical University named after S.D. Asfendiyarov", Chief Physician of the "Kazmed Company" Clinic, Almaty, Republic of Kazakhstan. ORCID: 0000-0003-2555-8644; Postal Address: 050012, Almaty, Tole Bi Street, 94, Department of Propedeutics of Internal Diseases; E-mail: nurgalieva.b@kaznmu.kz, +7 701 210 62 81;
Akzhalova Yuliya Ivanovna –a physician at "Kazmed Company"; E-mail: yuliya.lipai@mail.ru, +7 747 484 6050
Khaidarov Saken - a lecture on molecular biology nonprofit joint stock company "Kazakh National Medical University named after S.D. Asfendiyarov, ORCID:0000-0001-7770-8427
Moldakaryzova Aizhan Zhanarbekova - Cand. Sc. Biology, associate professor, NPJSC "Kazakh National Medical University named after S.D. Asfendiyarov", Almaty, Tole Bi Street, 94, Kazakhstan; 8 701-557-52-23; ORCID:0000-0003-0186-978X
1. Вакцинация против COVID-19 в Казахстане — Википедия http://ru.wikipedia.org/wiki/
2. Вакцина против COVID-19 в мире ru.wikipedia.org›wiki/Вакцина_против_COVID-19
3. Вакцинация против COVID-19 вакциной CoronaVac компании SinoVac (SinoVac CoronaVac): Краткое руководство. World Health Organization. July 2021:1–6.
4. Clinical Trial of Efficacy and Safety of Sinovac's Adsorbed COVID-19 (Inactivated) Vaccine in Healthcare Professionals (PROFISCOV). Available at: [clinicaltrials.gov]https://clinicaltrials.gov/study/NCT04456595). Last updated February 15, 2024.
5. Chile initiates clinical study for COVID-19 vaccine. Available at: [web.archive.org](https://web.archive.org/web/20201011190302/https://chilereports.cl/en/news/2020/08/04). (Accessed August 4, 2020).
6. King E.R., Towner E. A case of immune thrombocytopenia after BNT162b2 mRNA COVID-19 vaccination. Am J Case Rep. 2021. 22:e931478. doi:10.12659/AJCR.931478.
7. Lemoine C., Padilla C., Krampe N. et al. Systemic lupus erythematosus after Pfizer COVID-19 vaccine: a case report. Clin Rheumatol. 2022. 41(5):1597–1601. doi:10.1007/s10067-022-06126-x.
8. Meijiao Wang, Huanpeng Gu, Yingqi Zhai, Xuanlin Li, Lin Huang, Haichang Li, Zhijun Xie, Chengping Wen. Vaccination and the risk of systemic lupus erythematosus: a meta-analysis of observational studies Arthritis Res Ther. 2024 Mar 4.26:60. doi:10.1186/s13075-024-03296-8
9. Pfizer–BioNTech COVID-19 vaccine. Available at: [Wikipedia](https://en.wikipedia.org/wiki/Pfizer%E2%80%93BioNTech_COVID-19_vaccine). Accessed [Insert Date].
10. Radwi M., Farsi S. A case report of acquired hemophilia following COVID-19 vaccine. J Thromb Haemost. 2021.19(6):1515–1518. doi:10.1111/jth.15291.
11. Renisi G., Lombardi A., Stanzione M., et al. Anterior uveitis onset after BNT162b2 vaccination: is this just a coincidence? Int J Infect Dis. 2021. 110:95–97. doi:10.1016/j.ijid.2021.07.035.
12. Tang Y., Tao H., Gong Y. et al. Changes of serum IL-6, IL-17, and complements in systemic lupus erythematosus patients. J Interferon Cytokine Res. 2019.39(7):410–415. doi:10.1089/jir.2018.0169.
13. Turkey begins phase three trials of Chinese COVID-19 vaccine. Available at: [trtworld.com](https://www.trtworld.com/turkey/turkey-begins-phase-three-trials-of-chinese-covid-19-vaccine-39806). (Accessed August 4, 2020)
14. Wraith D.C., Goldman M., Lambert P.H. Vaccination and autoimmune disease: What is the evidence? Lancet. 2003.362:1659–1666. doi:10.1016/S0140-6736(03)14802
Number of Views: 99
Category of articles:
Clinical case
Bibliography link
Nurgaliyeva B., Akzhalova Yu., Khaidarov S., Moldakaryzova A. A Case of Autoimmune Complications Following COVID-19 Vaccination with SinoVac-CoronaVac (China) // Nauka i Zdravookhranenie [Science & Healthcare]. 2024. Vol.26 (6), pp. 230-233. doi 10.34689/SH.2024.26.6.026Related publications:
COMMUNITY-ACQUIRED PNEUMONIA IN PREGNANT. CLINICAL CASE.
A CASE OF AUTOIMMUNE COMPLICATIONS FOLLOWING COVID-19 VACCINATION WITH SINOVAC-CORONAVAC (CHINA)
EOSINOPHILIC GASTROINTESTINAL DISEASES IN CHILDREN. СLINICAL CASE.
USE OF A NEW DEVICE FOR DRAINAGE OF THE PLEURAL CAVITY IN CHILDREN
USTEKINUMAB: A GENETICALLY ENGINEERED BIOLOGIC FOR PSORIASIS TREATMENT – A CASE REPORT