SURVIVAL ANALYSIS FOR CERVICAL CANCER IN THE EAST KAZAKHSTAN REGION
Introduction. Cervical cancer (CC) is the fourth most common malignant neoplasm in women and seventh overall globally. The prognosis of the disease is affected by the stage of the disease, the condition of the lymph nodes, the depth and volume of the tumor. Five-year survival in case of unaffected lymph nodes by a tumor it can be 88-99%, in case of metastases in the lymph nodes of the pelvis it can be 50-74%.
Objective. The objective of the study was to analyze the survival rate for cervical cancer in the East Kazakhstan region.
Materials and Methods. Data from the Semey Regional Cancer Center (ROD Semey) and the regional oncology center of Ust-Kamenogorask (OOD-Ust-Kamenogorsk) were used. The study included all deaths from cervical cancer (337 cases) for the period from 2011 to 2016. Survival analysis was performed using the Kaplan-Meier method. A comparison was made between treatments.
Results. Radiation therapy was performed at 50,7% (n=171) of patients, chemotherapy was performed at 8,6% (n=29) of women, symptomatic therapy was performed at 35,6% (n=120) of patients, surgical treatment was performed at 4, 5% (n=15), conization was carried out at 0,6% (n=2). The mean survival time for surgical treatment was 29,7 (95%CI:15,4-43,9) months, for radiotherapy it was 25,0 (95%CI:21,5-28,6) months, for conization it was 18,5 (95%CI:0,0-116,3) months, for chemotherapy 12,4 (95%CI:9,9-14,8) months, for symptomatic therapy 8,8 (95%CI:6,4-11,2) months. Survival curves for all types of treatment were significantly different, the highest frequency of events were at patients who have received symptomatic treatment.
Conclusion. In summary, the longest time free from the outcome was at the surgical treatment, the prognosis was worse at patients who received symptomatic therapy.
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Шалгумбаева Г.М., Зготова Н.С., Фаизова Р.И., Хисметова А.М., Амренова К.Ш., Досбаева А.М., Юрковский А.О. Анализ выживаемости при раке шейки матки в Восточно-Казахстанской области // Наука и Здравоохранение. 2018. 5 (Т.20). С. 68-73. Shalgumbayeva G.M., Zgotava N.S., Faizova R.I., Khismetova A.M., Amrenova K.Sh., Dosbaeva A.M., Yurkovsky A.O. Survival analysis for cervical cancer in the East Kazakhstan region. Nauka i Zdravookhranenie [Science & Healthcare]. 2018, (Vol.20) 5, pp. 68-73. Шалгумбаева Г.М., Зготова Н.С., Фаизова Р.И., Хисметова А.М., Амренова К.Ш., Досбаева А.М., Юрковский А.О. Шығыс Қазақстан облысындағы жатыр мойнының қатерлі ісігі кезіндегі өміршеңдікке талдау // Ғылым және Денсаулық сақтау. 2018. 5 (Т.20). Б. 68-73.Related publications:
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