MOLECULAR CHARACTERIZATION OF MULTIDRUG RESISTANT M.TUBERCULOSIS STRAINS DISTRIBUTED IN THE TERRITORY OF KAZAKHSTAN
In spite of that the rate of tuberculosis is decreasing every year in Kazakhstan wide distribution of drug-resistant tuberculosis threatens tuberculosis control. According to various studies, M.tuberculosis W-Beijing genotype is associated with drug resistance and more severe forms of tuberculosis. Aim of the study: estimation of mutations spectrum in katG, fabG-inhA, oxyR-ahpC and rpoB responsible for drug resistance of M. tuberculosis to isoniazid and rifampicin, and determination of genetic families of 103 multidrug resistant clinical isolates of M.tuberculosis spread in Kazakhstan by Sanger method and spoligotyping, respectively. Among 103 multidrug resistant strains in Kazakhstan mutations at 531 codon Ser→Leu of rpoB gene (87,4%) and at 315 codon Ser→Thr of katG gene (97%) responsible for resistance to rifampicin and izoniazid respectively were prevailed. More than 80% of multidrug resistant M.tuberculosis strains were referred to Beijing genotype, the most virulent and widely spread genotype in the world. M. tuberculosis Beijing family strains prevail among multidrug and drug resistant strains in Kazakhstan.
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Аkhmetova A.Zh., Akilzhanova A.R., Molkenov A.B., Kairov U.E., Bismilda V.L., Chingissova L.T., Kozhamkulov U.A. Molecular characterization of multidrug resistant M.TUBERCULOSIS strains distributed in the territory of Kazakhstan // Nauka i Zdravookhranenie [Science & Healthcare]. 2019, (Vol.21) 5, pp. 45-52.Related publications:
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