СELL THERAPY FOR PARKINSON'S DISEASE: THE EFFECTIVENESS OF MINIMALLY INVASIVE METHODS OF TRANSPLANTATION
Background. Parkinson's disease (PD) is one of the most common neurodegenerative diseases in the world. Treatment of patients with Parkinson disease (PD) using autologous mesenchymal stem cells (MSCs) is a promising method to influence the pathogenesis of the disease.
The aim of the study was to evaluate the effectiveness of minimally invasive methods of transplantation autologous MSCs in doses less than 0.5 million / kg of patient's body weight.
Methods. The study included 34 patients with PD. Group A included 9 patients who received a single intravenous injection of MSCs suspension (the dose Me = 11.85 [10.00-19.20] × 106 cells in 10.0 ml of the prepared solution). The total dose was 0.16 × 106 / kg of patient's body weight. Group B included 12 patients who received a single transnasal injection of autologous MSCs (the dose Me = 10.15 [10.00-13.02] × 106 cells in a volume of 5 ml of the prepared solution). The comparison group included 13 patients who received placebo. Effectiveness of the therapy was evaluated 7 days post-transplantation by assessing motor symptoms of the disease.
Results. We found a statistically significant decrease in the severity of motor symptoms in the groups A and B in the post-transplant period. In the comparison group the dynamics of motor symptoms was not observed.
Conclusions. Positive results allow us to consider MSCs transplantation as a disease-modifying therapeutic strategy in PD. The effectiveness of minimally invasive methods of MSCs transplantation can be considered in the development of long-term maintenance therapy for Parkinson's disease.
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Aleinikava N.Ye., Chyzhyk V.A., Boika A.V., Nizheharodava D.B., Zafranskaya M.M., Ponomarev V.V. Сell therapy for Parkinson's disease: the effectiveness of minimally invasive methods of transplantation // Nauka i Zdravookhranenie [Science & Healthcare]. 2021, (Vol.23) 2, pp. 81-91. doi 10.34689/SH.2021.23.2.008Related publications:
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