MICROSCOPIC PECULIARITIES OF DIFFERENT FORM OF GASTROESOPHAGEAL REFLUX DISEASE
The work devoted for investigation of the prevalence and significance of microscopic changes in the esophageal mucosa in gastroesophageal reflux disease (GERD) for the biopsy results. It was studied 223 patients with biopsy, which have been diagnosed with GERD. Material was divided after comparing endoscopic and histological data into three subgroups: non-erosive GERD was referred 104 cases or 46.64%; the picture of erosive ulcerous form corresponded in 77 patients, or 34.53%; Barrett's esophagus was detected in 42 patients (18.8%). The following histological features were evaluated: degree of hyperplasia of basal cells, epithelial papillae elongation, the level of infiltration with leukocyte lymphocytic elements, the presence of erosive or ulcerative changes, the presence of metaplasia and dysplasia. Study of esophageal biopsies indicates cases of metaplasia (Barrett's esophagus) and esophageal dysplasia in GERD. All patients with GERD, a comprehensive diagnostic approach that combines not only endoscopic examination, but histological analysis of biopsy samples. Diagnostically most significant are the basal layer hyperplasia, infiltration of inflammatory cells for all forms of metaplasia and dysplasia detection for Barrett's esophagus.
Gargin V.V., Sakal V.V.
Kharkiv National Medical University, Ukraine
Institute of Therapy named after L.T. Malaya NAMS of Ukraine
1. Tutuian R. Update in the diagnosis of gastroesoph-ageal reflux disease. // J. Gastrointestin Liver Dis. – 2006. - Sep;15(3). P.243-247.
2. Champion G., Richter J.E., Vaezi M.F., Singh S., Alexander R. Duodenogastro-esophageal reflux: relationship to pH and importance in Barrett’s esophagus. // Gas-troenterology. – 1994. - 107(3). – P.747–754.
3. Thomas H., Wilhelm L., Petermann J., Rosenbaum K.D., Lorenz D. Simultaneous long-term measurement of duodenogastric reflux and gastroduodenal motility. // Chirurg. – 1997. - 68(6). – P.618–623.
4. Geboes K., Desmet V., Vantrappen G., Louvain A. Esophageal histology in the early stage of gastroesophageal reflux. // Arch Pathol Lab Med. – 1979. – 103. –P.205.
5. Papa A., Urgesi R., Danese S. et. al. Pathophysiology, diagnosis and tritment of non-erosiv reflux disease (NERD) // Minerva Gastroenterol. Dietol. - 2004. - Vol.50. - P.215-226.
6. Weinstein W.M., Ippoliti A.F. The diagnosis of Barrett’s esophagus: Goblets, goblets, goblets. // Gastrointest Endosc. – 1996. – 44. - P.91–94.
7. Egger K., Werner M., Meining A. et.al. Biopsy sur-veillance is still necessary in patients with Barrett’s esophagus despite new endoscopic imeging techniques / Gut. – 2003. – 52. – Р.18-23.
8. Vakil N., van Zanten S.V., Kahrilas P., Dent J., Jones R. The Montreal definition and classification of gas-troesophageal reflux disease: a global evidence-based consensus. // Am J Gastroenterol. 2006. - 101(8) – P.1900-1920.
9. Oberg S., Wenner J., Johansson J., Walther B., Willen R. Barrett esophagus: risk factors for progression to dysplasia and adenocarcinoma. // Ann Surg. – 2005. - 242(1). – P.49-54.
10. Mueller J., Werner M., Stolte M. Barrett's esophagus: histopathologic definitions and diagnostic criteria. // World J Surg. – 2004. - 28(2). – P.148-154.
11. Glickman J.N., Chen Y.Y., Wang H.H., Antonioli D.A., Odze R.D. Phenotypic characteristics of a distinctive multilayered epithelium suggests that it is a precursor in the development of Barrett's esophagus. // Am J Surg Pathol. – 2001. - 25(5). - P569-578.
12. Riddell R.H. The genesis of Barrett esophagus: has a histologic transition from gastroesophageal reflux disease-damaged epithelium to columnar metaplasia ever been seen in humans? // Arch Pathol Lab Med. – 2005. - 129(2). – P.164-169.
13. Lagergren J., Bergstrom R., Lindgren A., Nyren O. Symptomatic gastroesophageal reflux as a risk factor for esophageal adenocarcinoma. // N Engl J. – 1999. – 18. -P.825–831.
14. Dent J. Microscopic esophageal mucosal injury in nonerosive reflux disease. // Clin Gastroenterol Hepatol. – 2007. - 5(1). P4-16.
15. Vieth M., Haringsma J., Delarive J., Wiesel P.H., Tam W., Dent J., et al. Red streaks in the oesophagus in patients with reflux disease: is there a histomorphological correlate? // Scand J Gastroenterol. – 2001. - 36(11). – P.1123-1127.
Количество просмотров: 489
Категория статей:
Статьи
Библиографическая ссылка
Гаргин В.В., Сакал В.В. Харьковский национальный медицинский университет, Украина, Институт терапии имени Л.Т. Малай НАМН Украины // Наука и Здравоохранение. 2014.№ 2. С.38-40 Gargin V.V., Sakal V.V. MICROSCOPIC PECULIARITIES OF DIFFERENT FORM OF GASTROESOPHAGEAL REFLUX DISEASE // Nauka i Zdravookhranenie. 2014.№ 2. С. 38-40 Гаргин В.В., Сакал В.В. Харьков ұлттық медициналық университеті, Украина, Л.Т. Малай атынд. терапия институты, Украина ҰМҒА // Ғылым және Денсаулық сақтау 2014.№ 2. С. 38-40 В.В., Сакал В.В. Харьковский национальный медицинский университет, Украина, Институт терапии имени Л.Т. Малай НАМН Украины // Наука и Здравоохранение. 2014.№ 2. С.38-40 Gargin V.V., Sakal V.V. MICROSCOPIC PECULIARITIES OF DIFFERENT FORM OF GASTROESOPHAGEAL REFLUX DISEASE // Nauka i Zdravookhranenie. 2014.№ 2. С. 38-40 Гаргин В.В., Сакал В.В. Харьков ұлттық медициналық университеті, Украина, Л.Т. Малай атынд. терапия институты, Украина ҰМҒА // Ғылым және Денсаулық сақтау 2014.№ 2. С. 38-40Похожие публикации:
МЕТОДЫ РАБОТЫ МЕДИЦИНСКИХ СЕСТЕР С ПАЦИЕНТАМИ, ИМЕЮЩИМИ ПОВЕДЕНЧЕСКИЕ ФАКТОРЫ РИСКА (КУРЕНИЕ, АЛКОГОЛЬ): ОБЗОР ЛИТЕРАТУРЫ
ВЗАИМОСВЯЗЬ ИНСУЛИНОРЕЗИСТЕНТНОСТИ И ПОЛИМОРФИЗМОВ ГЕНОВ ЛИПИДНОГО ОБМЕНА И РЕНИН-АНГИОТЕНЗИН-АЛЬДОСТЕРОНОВОЙ СИСТЕМЫ. ОБЗОР ЛИТЕРАТУРЫ
ГЕНЕТИЧЕСКИЕ АСПЕКТЫ ИДИОПАТИЧЕСКОЙ ФОРМЫ ПРИВЫЧНОГО НЕВЫНАШИВАНИЯ БЕРЕМЕННОСТИ. ОБЗОР ЛИТЕРАТУРЫ
Тұжырым НИМЕСУЛИД ҚОЛДАНЫСЫНЫҢ ТИІМДІЛІГІНІҢ САРАПШЫЛЫҒЫ БАС ЖАС ЕМДЕЛУШІЛЕРІНІҢ ДОРСАЛГИЯЛАРМЕН, ОМЫРТҚАНЫҢ ОСТЕОХОНДРОЗЫНЫҢ КЛИНИКАЛЫҚ МАНИФЕСТІМЕН ШАҚЫРТҚАН
EVALUATION OF EFFECTIVENESS OF DICLOBERL® USING AT A HOSPITAL STAGE IN PATIENTS WITH DORSOPATHIES, ACCOMPANIED DORSALGY