DETERMINATION OF MUTATIONS IN KATG, FABG-INHA, AHPC-OXYR GENES RESPONSIBLE FOR IZONIAZID-RESISTANCE AMONG CLINICAL ISOLATES OF M. TUBERCULOSIS FROM DIFFERENT REGIONS OF KAZAKHSTAN
Spectrum of mutations in genes that cause resistance to isoniazid in clinical isolates of M. tuberculosis circulating in 3 regions of Kazakhstan (Almaty, Kostanay, Kyzylorda regions) was estimated in this study. High frequency of mutations at 315 codon of katG gene (97,1%; 92,3%; 69,2% respectively) responsible for resistance to isoniazid was detected among M. tuberculosis isolates distributed in mentioned regions.
1 A.Zh. Аkhmetova, 1 S.E. Rakhimova, 2 L.T. Chingissova, 1 К.Y. Berikkhanova, 1 R.B. Issayeva, 1 А.R. Аkilzhanova
1 Center for Life Sciences, Nazarbayev University, Astana,
2 National Center for Tuberculosis Problems, Almaty
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А.Ж. Ахметова, С.Е. Рахимова, Л.Т. Чингисова, К.Е. Берикханова, Р.Б. Исаева, А.Р. Акильжанова ОПРЕДЕЛЕНИЕ МУТАЦИЙ В ГЕНАХ KATG, FABG-INHA, AHPC-OXYR, ОБУСЛАВЛИВАЮЩИХ УСТОЙЧИВОСТЬ К ИЗОНИАЗИДУ, СРЕДИ КЛИНИЧЕСКИХ ИЗОЛЯТОВ M. TUBERCULOSIS ИЗ РАЗЛИЧНЫХ ОБЛАСТЕЙ КАЗАХСТАНА.//Наука и Здравоохранение 2014.№ 5. С. 45-47 A.Zh. Аkhmetova, S.E. Rakhimova, L.T. Chingissova, К.Y. Berikkhanova, R.B. Issayeva, А.R. Аkilzhanova DETERMINATION OF MUTATIONS IN KATG, FABG-INHA, AHPC-OXYR GENES RESPONSIBLE FOR IZONIAZID-RESISTANCE AMONG CLINICAL ISOLATES OF M. TUBERCULOSIS FROM DIFFERENT REGIONS OF KAZAKHSTAN// Nauka i Zdravookhranenie. 2014.№ 5. С. 45-47 А.Ж. Ахметова, С.Е. Рахимова, Л.Т. Чингисова, К.Е. Берикханова, Р.Б. Исаева, А.Р. Акильжанова ҚАЗАҚСТАННЫҢ ӘР ТҮРЛІ ОБЛЫСТАРЫНДА ТАРАЛҒАН M. TUBERCULOSIS ИЗОЛЯТТАРЫНЫҢ ИЗОНИАЗИДКЕ ТӨЗІМДІЛІГІН АНЫҚТАЙТЫН KATG, FABG-INHA, AHPC-OXYR ГЕНДЕРІНДЕГІ МУТАЦИЯЛАРДЫ АНЫҚТАУ.// Ғылым және Денсаулық сақтау 2014.№ 5. С. 45-47Похожие публикации:
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