THE CLINICAL EFFECT OF PROBIOTIC-CONTAINING PRODUCT ON HEALTH INDICATORS AMONG A POPULATION OF CENTRAL ASIA
Introduction. The main goal is to test the efficacy of a synbiotic product which consists of the selected probiotic strains (Lactobacillus plantarum, Lactobacillus fermentum, Lactobacillus acidophilus, Bifidobacterium longum, Bifidobacterium bifidum), inulin, pectin, and fish collagen in adults diagnosed with metabolic syndrome.
Materials and methods. This double-blind placebo-controlled trial was conducted among 180 participants aged 25 to 75 years. Subjects with and without metabolic syndrome were randomly assigned to receive synbiotic or placebo daily for three months. 134 of 180 participants completed the study.
Results. Compared with the placebo group, the synbiotic group had significantly decreased total cholesterol (TC) from 5.16±0.95 to 4.86±0.86 mmol/L, due to lowering the levels of LDL and triglyceride (p <0.0005). The present findings suggest positive influence of the tested synbiotic on controlling excess weight and in treating some metabolic disorders in adults.
Conclusion We conclude that the presented synbiotic formulation here has potential within efforts to reduce the risk and progression of the metabolic syndrome. This trial suggests beneficial effects of a synbiotic supplement for controlling excess weight, as well as the progression of some metabolic disorders, as determined from circulating levels of risk factor biomarkers among adults.
Almagul R. Kushugulova1,2*, http://orcid.org/0000-0001-9479-0899
Sofia K. Forslund3,4,5,6, https://orcid.org/0000-0003-4285-6993
Samat S. Kozhakhmetov1,2, https://orcid.org/0000-0003-4358-7879
Ulykbek E. Kairov1, http://orcid.org/0000-0001-8511-8064
Askhat B. Molkenov1, http://orcid.org/0000-0003-2339-5204
Shynggys D. Sergazy1,2, https://orcid.org/0000-0002-6030-620X
Saule A. Saduakhassova2,
Gulzhanat S. Urazbayeva7, https://orcid.org/0000-0001-6723-4598
Saltanat Ch. Beysembayeva7,
Raushan Zh. Karabaeva7,
Roza A. Bakenova7,
Talgat S. Nurgozhin8, https://orcid.org/0000-0002-8036-604X
Valery V. Benberin7, https://orcid.org/0000-0002-7286-1593
Zhaxybay Sh. Zhumadilov1, 9, https://orcid.org/0000-0003-3855-6429
Bork Peer6, https://orcid.org/0000-0002-2627-833X
Institutes:
1 National Laboratory Astana, Nazarbayev University, Nur-Sultan, Republic of Kazakhstan;
2 Kazakhstan society of researchers of human microbiome”, Nur-Sultan, Republic of Kazakhstan;
3 Experimental and Clinical Research Center, a cooperation of Charité-Universitätsmedizin Berlin and Max Delbruck Center for Molecular Medicine, 13125 Berlin, Germany;
4 Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany;
5 Max Delbruck Center for Molecular Medicine in the Helmholtz Association, 13125 Berlin, Germany;
6 The European Molecular Biology Laboratory (EMBL), Structural and Computational Biology Unit, Heidelberg, Germany;
7 Medical Centre Hospital of President’s Affairs Administration of the Republic of Kazakhstan, Astana, Republic of Kazakhstan;
8 Asfendiyarov Kazakh National Medical University, Almaty, Republic of Kazakhstan;
9 University Medical Center, Nazarbayev University, Nur-Sultan, Republic of Kazakhstan.
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Кушугулова А.Р., Форсланд С.K., Кожахметов С.С., Каиров У.E., Молкенов А.Б., Сергазы Ш.Д., Садуахасова С.А., Уразбаева Г.С., Бейсембаева С.Ч., Карабаева Р.Ж., Бакенова Р.А., Нургожин Т.С., Бенберин В.В., Жумадилов Ж.Ш., Пир Б. Клинический эффект пробиотик-содержащего продукта на показатели здоровья в популяции Центральной Азии // Наука и Здравоохранение. 2020. 2(Т.22). С. 49-60. doi 10.34689/SH.2020.22.2.005Похожие публикации:
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