Online ISSN: 3007-0244,
Print ISSN:  2410-4280
THE PROGNOSTIC VALUE OF LEUKOCYTE IN CEREBROVASCULAR DISEASES
Introduction. Among adult neurological diseases, cerebrovascular diseases (CVD) are common and important. Therefore, to fight against the preventable prognostic factors in these patients has an important role in reducing the severity of the disease. Methods. In this study, during the six-month period, 98 patients hospitalized at the neurology services after the first evaluation at the emergency department were examined retrospectively. Their white blood cell (WBC) counts are recorded and the relationship of them with mortality in the hospital was researched. Median of the age was 73 (37-99). M:F ratio was 0.78. Results. 87(88.8%) of the patients diagnosed as ischemic CVD and others were hemorrhagic CVD. In hospital mortality was 19.4%, %66.3 of them were discharged with sequel and %14.3 of them without any complication and sequel. Mean value of WBC was 9.30±3.31 (10^3/µL) in ischemic CVD and 10.05±5.45 (10^3/µL) in hemorrhagic CVD group, there wasn't any statistical difference. WBC values of dead patient group was higher than the alive patient group. Conclusion. In alive patient group, there wasn't any difference of WBC between patient with and without sequel. There wasn't any relationship between type of CVD and prognosis. Leucocytes contribute the onset and continuation of ischemic CVD and elevations in leukocytes may be independently associated with markers of subclinical atherosclerosis and increased risk of ischemic stroke. The increased level of the WBC of patients diagnosed with CVD was considered to be an important role in the severity of the disease.
Ahmet Burak Erdem1-2, Umut Yücel Çavuş2, Ahmet Ceylan2, Ural Kaya2, Fatih Büyükcam2, Cemil Kavalcı2 1 Ankara State Hospital, Emergency Medicine Department, Ankara, Turkey 2 Ankara Dışkapı Yıldırım Beyazıt Training and Resarch Hospital, Emergency Medicine Department, Ankara, Turkey.
1. Akopov S.E., Simonian N.A., Grigorian G.S. Dynamics of polymorphonuclear leukocyte accumulation in acute cerebral infarction and their correlation with brain tissue damage // Stroke. 1996;27(10):1739-43. Epub 1996/10/01. 2. Altinbilek E., Ozturk D., Algın A., Caltili C., Calik M., Sahin B., Kavalci G., Kavalci C. The Role of Mean Platelet Volume and Neutrophil Lymphoscyte Ratio Determınıng. Early Mortality in Stroke Patıents // Science & Healthcare 2019; 6 (V.21): 30-33 DOI 10.34689/SH.2019.21.54541 3. Anderson R.E., Tan W.K., Martin H.S., Meyer F.B. Effects of glucose and PaO2 modtion on cortical intracellular acidosis, NADH redox state, and infarction in the ischemic penumbra // Stroke. 1999;30(1):160-70. Epub 1999/01/08. 4. Arauz A., Murillo L., Cantu C., Barinagarrementeria F., Higuera J. Prospective study of single and multiple lacunar infarcts using magnetic resonance imaging: risk factors, recurrence, and outcome in 175 consecutive cases // Stroke. 2003;34(10):2453-8. Epub 2003/09/23. 5. Ates A.H., Canpolat U., Yorgun H., Kaya E.B., Sunman H., Demiri E., Taher A., Hazirolan T., Aytemir K., Tokgozoglu L., Kabakci G., Oto A. Total white blood cell count is associated with the presence, severity and extent of coronary atherosclerosis detected by dual-source multislice computed tomographic coronary angiography // Cardiol J. 2011;18(4):371-7. Epub 2011/07/20. 6. Celik T., Bugan B. White blood cell count and stable coronary artery disease: the role of neutrophil to lymphocyte ratio // Cardiol J. 2011;18(6):720; author reply 1. Epub 2011/11/25. 7. Furie M.B., Randolph G.J. Chemokines and tissue injury // Am J Pathol. 1995;146(6):1287-301. Epub 1995/06/01. 8. Garcia J.H., Liu K.F., Yoshida Y., Lian J., Chen S., del Zoppo G.J. Influx of leukocytes and platelets in an evolving brain infarct (Wistar rat) // Am J Pathol. 1994;144(1):188-99. Epub 1994/01/01. 9. Garcia J.H., Liu K.F., Ho K.L. Neuronal necrosis after middle cerebral artery occlusion in Wistar rats progresses at different time intervals in the caudoputamen and the cortex // Stroke. 1995;26(4):636-42. 10. Güven H., Çilliler A.E., Sarıkaya S.A., Köker C., Çomoğlu S.S. Erken Lökosit ve Nötrofil Yüksekliğinin Akut İskemik İnmede Etyolojik ve Prognostik Önemi // Journal of Neurological Sciences. 2010;27:311-8. 11. Hartl R., Schurer L., Schmid-Schonbein G.W., del Zoppo G.J. Experimental antileukocyte interventions in cerebral ischemia // J Cereb Blood Flow Metab. 1996;16(6):1108-19. Epub 1996/11/01. 12. Imtiaz F., Shafique K., Mirza S.S., Ayoob Z., Vart P., Rao S. Neutrophil lymphocyte ratio as a measure of systemic inflammation in prevalent chronic diseases in Asian population // Int Arch Med. 2012;5(1):2. Epub 2012/01/28. 13. Kavalci C., Genchallac H., Durukan P., Cevik Y. Value Of Biomarker-Based Diagnostic Test in Differentıal Diagnosis of Hemorrhagic-Ischemic Stroke // Bratislava Medical Journal, 2011;112:398-40 14. Klijn C.J., Hankey G.J. Management of acute ischaemic stroke: new guidelines from the American Stroke Association and European Stroke Initiative // Lancet Neurol. 2003;2(11):698-701. 15. Lindsberg P.J., Roine R.O. Hyperglycemia in acute stroke // Stroke. 2004;35(2):363-4. Epub 2004/02/06. 16. Mankovsky B.N., Patrick J.T., Metzger B.E., Saver J.L. The size of subcortical ischemic infarction in patients with and without diabetes mellitus // Clin Neurol Neurosurg. 1996;98(2):137-41. Epub 1996/05/01. 17. Matsuo Y., Onodera H., Shiga Y., Nakamura M., Ninomiya M., Kihara T., Kogure K. Correlation between myeloperoxidase-quantified neutrophil accumulation and ischemic brain injury in the rat //. Effects of neutrophil depletion. Stroke. 1994; 25(7):1469-75. Epub 1994/07/01. 18. Ozdemir G., Ozkan S., Uzuner N., Ozdemir O. Türkiye’de Beyin Damar Hastalıkları için Risk Faktörleri Türk Beyin Damar Hastalıkları Dergisi 2000;6:31-3. 19. Ridker P.M. Inflammatory biomarkers, statins, and the risk of stroke: cracking a clinical conundrum // Circulation. 2002;105(22):2583-5. Epub 2002/06/05. 20. Rodriguez-Yanez M., Castillo J. Role of inflammatory markers in brain ischemia // Curr Opin Neurol. 2008;21(3):353-7. Epub 2008/05/03. 21. Sharaiha R.Z., Halazun K.J., Mirza F., Port J.L., Lee P.C., Neugut A.I., Altorki N.K., Abrams J.A. Elevated preoperative neutrophil:lymphocyte ratio as a predictor of postoperative disease recurrence in esophageal cancer // Ann Surg Oncol. 2011;18(12):3362-9. 22. Shen X.H., Chen Q., Shi Y., Li H.W. Association of neutrophil/lymphocyte ratio with long-term mortality after ST elevation myocardial infarction treated with primary percutaneous coronary intervention // Chin Med J (Engl). 2010;123(23):3438-43. 23. Steinberg H.O., Tarshoby M., Monestel R., Hook G., Cronin J., Johnson A., Bayazeed B., Baron A.D. Elevated circulating free fatty acid levels impair endothelium-dependent vasodilation // J Clin Invest. 1997;100(5):1230-9. Epub 1997/09/01. 24. Whisnant J.P., Basford J.R., Bernstein E.F., Cooper E.S., Dyken M.L., Easton J.D., Little J.R., Marler J.R., Millikan C.H., Petito C.K., Price T.R., Raichle M.E., Robertson J.T., Thiele B., Walker M.D., Zimmerman R.A. Special Report From The National Institute of Neurological Disorders and Stroke // Classification of Cerebrovascular Diseases III. Stroke. 1990; 21: 637-76.
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Erdem A.B., Çavuş U.Y., Ceylan A., Kaya U., Fatih B., Kavalcı C. Прогностическая ценность лейкоцитарного показателя при цереброваскулярных заболеваниях // Наука и Здравоохранение. 2020. 2(Т.22). С. 61-65. doi 10.34689/SH.2020.22.2.006

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