RISK FACTORS FOR AGE-RELATED DEMENTIA IN KAZAKHSTAN: A CASE-CONTROL STUDY
To our knowledge, no population-based studies have been conducted on dementia in Kazakhstan yet. The aim of our pilot research was evaluation of the risk factors of Alzheimer’s disease and vascular dementia in Kazakhstani settings. 79 patients of dementia (37 males and 42 females) and 121 healthy controls (50 males and 71 females) were included in the study. Among 79 dementia cases 45 (57%) had Alzheimer’s dementia, 34 (43%) vascular dementia. Dementia patients varied in age from 50 to 85 years, with a mean of 67.5 ± SD 8.3 years. There were 42 (53%) females and 37 (47%) males. A logistic regression analysis was employed to calculate odds ratios (OR) and corresponding 95% confidence intervals (CI) for potential factors associated with dementia. In our cohort, a significant risk factor for AD and VD was a nearly childhood in rural areas and small towns, whereas obtaining at least secondary education had protective effect on vascular dementia. Surprisingly, higher body mass index, having history of heart disease, high blood pressure and stroke had negative association with Alzheimer’s dementia. These findings may be useful for facilitating advanced research on dementia and developing prevention plan of age-related dementias in Kazakhstan.
Aiym Kaiyrlykyzy1*, Andrey Tsoy1, Farkhad Olzhayev1, Dinara Alzhanova2, Alma Zhussupova2, Sholpan Askarova1 1 Laboratory of Bioengineering and Regenerative Medicine, Center for Life Sciences, National Laboratory Astana, Nazarbayev University, Nur-Sultan, Republic of Kazakhstan; 2 Department of Neurology, Astana Medical University, Nur-Sultan, Republic of Kazakhstan.
1. Chapman D.P., Strine T.W., Anda R.F., Moore M.J. Dementia and its implications for public health. In: Preventing Chronic Disease; 2006. 3(2):A34. 2. Cholerton B., Baker L.D., Montine T.J., Craft S. Type 2 Diabetes, Cognition, and Dementia in Older Adults: Toward a Precision Health Approach. Diabetes spectrum : a publication of the American Diabetes Association 2016,29: pp. 210-219. 3. de la Monte S.M., Wands J.R. Alzheimer's disease is type 3 diabetes-evidence reviewed // Journal of diabetes science and technology 2008,2: pp. 1101-1113. 4. Gabin J.M., Tambs K., Saltvedt I., Sund E., Holmen J. Association between blood pressure and Alzheimer disease measured up to 27 years prior to diagnosis: the HUNT Study // Alzheimer's research & therapy 2017,9:37-37. 5. Järvenpää Tarja*; Rinne, Juha O. Koskenvuo, Markku‡; Räihä, Ismo§; Kaprio, Jaakko Binge Drinking in Midlife and Dementia Risk, Epidemiology: November 2005 - Volume 16 - Issue 6 - p 766-771. 6. Kivimäki M., Luukkonen R., Batty G.D., Ferrie J.E., Pentti J., Nyberg S.T., et al. Body mass index and risk of dementia: Analysis of individual-level data from 1.3 million individuals // Alzheimer's & dementia : the journal of the Alzheimer's Association 2018,14:601-609. 7. Klonoff-Cohen H. The role of procedural vs. chronic stress and other psychological factors in IVF success rates. In: Life Style and Health Research Progress; 2008. pp. 67-85. 8. McKhann G., Drachman D., Folstein M., Katzman R., Price D., Stadlan E.M. Clinical diagnosis of Alzheimer’s disease // Neurology 1984,34:939. 9. McKhann G.M., Knopman D.S., Chertkow H., Hyman B.T., Jack C.R., Kawas C.H., et al. The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease // Alzheimer's & dementia: the journal of the Alzheimer's Association 2011,7:263-269. 10. Nieoullon A. Neurodegenerative diseases and neuroprotection: current views and prospects // Journal of Applied Biomedicine 2011,9:173-183. 11. Østergaard S.D., Mukherjee S., Sharp S.J., Proitsi P., Lotta L.A., Day F., et al. Associations between Potentially Modifiable Risk Factors and Alzheimer Disease: A Mendelian Randomization Study // PLoS medicine 2015,12:e1001841-e1001841. 12. Prince M. AE, Guerchet M., Prina M. World Alzheimer Report 2014. Dementia and Risk Reduction. In. London: Alzheimer's Disease International; 2014.pp. 7-10 13. Prince M. Methodological issues for population-based research into dementia in developing countries. A position paper from the 10/66 Dementia Research Group // International Journal of Geriatric Psychiatry 2000,15:21-30. 14. Rizzi L., Rosset I., Roriz-Cruz M. Global Epidemiology of Dementia: Alzheimer’s and Vascular Types // BioMed Research International 2014,2014:8. 15. Russ T.C., Batty G.D., Hearnshaw G.F., Fenton C., Starr J.M. Geographical variation in dementia: systematic review with meta-analysis // International journal of epidemiology 2012,41:1012-1032. 16. Seriana van den Berg M.S. Policy brief. Risk factors for dementia. In; 2012.pp. 2-3 17. Takeda S., Rakugi H., Morishita R. Roles of vascular risk factors in the pathogenesis of dementia // Hypertens Res. 2020;43(3):162-167. 18. Wang X-J, Xu W, Li J-Q, Cao X-P, Tan L, Yu J-T. Early-Life Risk Factors for Dementia and Cognitive Impairment in Later Life: A Systematic Review and Meta-Analysis // Journal of Alzheimer's Disease 2019,67:221-229.
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Kaiyrlykyzy A., Tsoy A., Olzhayev F., Alzhanova D., Zhussupova A., Askarova Sh. Risk factors for age-related dementia in Kazakhstan: a case-control study // Nauka i Zdravookhranenie [Science & Healthcare]. 2020, (Vol.22) 4, pp. 80-85. doi 10.34689/SH.2020.22.4.008

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