ANALYSIS OF THE IMPLEMENTATION OF CLINICAL MANIFESTATIONS OF COVID-19 IN CONTACT PERSONS
Introduction. The emergence of a new coronavirus infection (COVID-19) caused by the SARS-CoV-2 virus, which first appeared in December 2019, has led to a rapid spread and a global pandemic with 103 million cases reported worldwide. The clinical picture of COVID-19 develops within 14 days after infection, on average, 97,5% of people experience symptoms within 11.5 days. COVID-19 can progress from asymptomatic infection to extremely severe, critical (acute respiratory failure (ARF), acute respiratory distress syndrome (ARDS), shock, multiple organ failure syndrome (MOFS)).
Purpose of the study. To investigate the age characteristics, comorbidities and timing of the main clinical symptoms of COVID-19 in contact patients.
Methods. A retrospective study was carried out, including the collection of clinical data from electronic medical records of patients with COVID-19 who were hospitalized from March 13 to June 5, 2020, taken from the Integrated Medical Information System (CMIS) from all regions of Kazakhstan. The data obtained were processed by descriptive statistics methods.
Results. We analyzed 5326 electronic medical records of patients with COVID-19, of which 94,4% (n = 5011) patients at the time of laboratory confirmation (PCR +) had clinical manifestations of COVID-19 of varying severity, and the remaining 315 were hospitalized as contact persons with positive PCR SARS-CoV-2, in the process of further monitoring it was found that 5,6% of patients realized clinical manifestations of COVID-19 of varying severity during the period of inpatient treatment.
Conclusions. Early detection and monitoring of contact persons with COVID-19 allows the identification of patients from the “risk group” and timely treatment, which helps to reduce the risk of complications. Patients with a mild and asymptomatic course pose a high risk in the continuation of the pandemic and are the cause of a severe epidemiological situation. The results obtained show the importance of early detection, isolation and monitoring of persons in contact with COVID-19. This study with reliable and timely information obtained contributes to timely preventive, therapeutic and diagnostic measures, which contributes to a significant reduction in deaths among people of the "risk group".
Aitolkyn Mynzhanova 1, https://orcid.org/0000-0002-3015-4153
Dinagul A. Baesheva 1,2, https://orcid.org/0000-0001-9129-5825
Aliya K. Omarova 1,2, Meruert O. Khamitova 1,2, Aiganym U. Daulbaeva 1,2
Bayan R. Turdalina 1,2, https://orcid.org/0000-0002-5219-0753
Aliya J. Seydullaeva 1,2, https://orcid.org/0000-0002-7513-5677
Aygerim A. Zhuzzhasarova1, https://orcid.org/0000-0001-6556-4489
Alyona V. Altynbekova 1,2, https://orcid.org/0000-0002-4407-4525
Ulyana A. Kirpicheva 3,
Almagul А. Kushugulova 4, https://orcid.org/0000-0001-9479-0899
Samat S. Kozhakhmetov 4,5, https://orcid.org/0000-0001-9668-0327
1 NJSC ”Medical University Astana”, Nur-Sultan, Republic of Kazakhstan;
2 Multidisciplinary City Children's Hospital № 3, Nur-Sultan, Republic of Kazakhstan;
3 "Scientific-practical center of sanitary-epidemiological examination and monitoring" of RSE on PVC "National center of public health" MH RK, Nur-Sultan, Republic of Kazakhstan ;
4 National Laboratory Astanа, Nazarbayev University, Nur-Sultan, Republic of Kazakhstan;
5 ArtScience Innovative Center, Nur-Sultan, Republic of Kazakhstan.
1. Акимкин В.Г., Кузин С.Н., Семененко Т.А., Плоскирева А.А., Дубоделов Д.В., Тиванова Е.В., Пшеничная Н.Ю., Каленская А.В. и др. Гендерно-возрастная характеристика пациентов. DOI: 10.21055/0370-1069-2020-3-27-35.
2. Акимкин В.Г., Кузин С.Н., Семененко Т.А., Шипулина О.Ю., Яцышина С.Б., Тиванова Е.В. и др. Закономерности эпидемического распространения SARS-CoV-2 в условиях мегаполиса // Вопросы вирусологии. 2020; 65(4):203–211. DOI: 10.36233/0507-4088-2020-65-4-203-211.
3. Ahmad R. Sedaghat, Isabelle Gengler, Marlene M. Speth. Review Otolaryngol Head Neck Surg. 2020 Jul;163(1):12-15. doi: 10.1177/0194599820926464. Epub 2020 May 5. Olfactory Dysfunction: A Highly Prevalent Symptom of COVID-19 With Public Health Significance Affiliations expand PMID: 32366160 DOI: 10.1177/0194599820926464.
4. CDC COVID-19 Response Team. Coronavirus Disease 2019 in Children – United States, February 12 – April 2, 2020. MMWR Morb. Mortal. Wkly Rep. 2020; 69(14):422–26. DOI: 10.15585/mmwr.mm6914e4.
5. Chun М., Zhou M, Dong X et al. Epidemiological and clinical characteristics of 99 cases of new coronavirus pneumonia 2019 in Wuhan, China: a descriptive study // Lancet 2020; 395 :507-13.
6. Dhochak N., Singhal T., Kabra S.K., Lodha R. Pathophysiology of COVID-19: why children fare better than adults? // Indian J Pediatr. 2020; 87(7):537–46. DOI: 10.1007/s12098-020- 03322-y.
7. Dong Y., Mo X., Hu Y., Qi X., Jiang F., Jiang Z., Tong S. Epidemiology of COVID-19 among children in China // Pediatrics. 2020; 145(6):e20200702.DOI: 10.1542/peds.2020-0702.
8. Gu H., Xie Z., Li T., Zhang S., Lai C. et al. Angiotensin-converting enzyme 2 inhibits lung injury induced by respiratory syncytial virus // Sci Rep.2016. v.6. Р.19840
9. Guan W-j, Ni Z-y, Hu Y. et al. Clinical characteristics of coronavirus disease 2019 in China . N Engl J Med 2020; 382 : 1708–20.
10. He f., Deng Y., Li V. Coronavirus disease 2019 (COVID-19): what do we know? J Med Virol 2020. 92 (7): 719-725, 14 March 2020.
11. He X., Lau E.H.Y., Wu P. et al (2020) Temporal dynamics in viral shedding and transmissibility of COVID-19 // Nat Med. 10.1038/s41591-020-0869-5
12. Jerome R Lechien, Carlos M Chiesa-Estomba, Daniele R De Siati, Mihaela Horoi, Serge D Le Bon, Alexandra Rodriguez, Didier Dequanter, Serge Blecic Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): a multicenter European study Multicenter Study Eur Arch Otorhinolaryngol. 2020 Aug;277(8):2251-2261. doi: 10.1007/s00405-020-05965-1. Epub 2020 Apr 6.
13. Jiang F., Deng L., Zhang L., Cai Y., Cheung C.W., Xia Z. Review of clinical characteristics of coronavirus disease 2019 (COVID ‐ 19) // J Gen Intern Med. 2020 May;35(5):1545-1549. doi: 10.1007/s11606-020-05762-w. Epub 2020 Mar 4.
14. Klopfenstein T., Kadiane-Oussou N.J., Toko L., Royer P.Y., Lepiller Q., Gendrin V. Features of anosmia in COVID-19 // Med Mal Infect. 2020 doi: 10.1016/j.medmal.2020.04.006. [pii: S0399-077X(20)30110-4, Apr 17.
15. Lauer S.A., Grantz K.H., Bi K. et al . Incubation period of coronavirus disease 2019 (COVID-19) from officially registered confirmed cases: assessment and application // Ann Int Med 2020; 172 : 577.
16. Li L.Q., Huang T., Wang Y.Q. et al 2019 novel coronavirus patients' clinical characteristics, discharge rate and fatality rate of meta‐analysis // J Med Virol. 2020; 92: 577–83.
17. Li Q., Guan X., Wu P., et al. Early Transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia // N Engl J Med. 2020;382:1199–1207. doi: 10.1056/NEJMoa2001316.
18. Luers J.C., Rokohl A.C., Loreck N., Wawer Matos P.A., Augustin M., Dewald F. Olfactory and gustatory dysfunction in coronavirus disease 19 (COVID-19) // Clin Infect Dis. 2020 doi: 10.1093/cid/ciaa525, May 1.
19. Ludvigsson J.F. Systematic review of COVID-19 in children shows milder cases and a better prognosis than adults // Acta Paediatr. 2020; 109(6):1088–95. DOI: 10.1111/apa.15270.
20. Mizumoto K., Kagaya K., Zarebski A., Chowell G. Estimating the asymptomatic proportion of coronavirus disease 2019 (COVID-19) cases on board the Diamond Princess cruise ship, Yokohama, Japan, 2020 // Euro Surveill. (2020) 25:2000180. doi: 10.2807/1560-7917.ES.2020.25.10.2000180.
21. She J., Liu L., Liu W. COVID-19 epidemic: disease characteristics in children // J. Med. Virol. 2020; 92(7):747–54. DOI: 10.1002/jmv.25807.
22. Singhal T.A. Review of Coronavirus Disease ‐2019 (COVID‐19) // Indian J Pediatr. 2020; 87: 281–6.
23. Sun P., Lu X., Xu C., Sun W., Pan B. Understanding of COVID‐19 based on current evidence // J Med Virol. 2020; 92: 548–51.
24. Varble Nicole, Maxime Blain, Michael Kassin, Sheng Xu, Evrim B. Turkbey, Amel Amalou, Dilara Long, Stephanie Harmon et al. Author information Article notes Copyright and License information and clinical assessment in asymptomatic and pre-symptomatic patients with early SARS-CoV-2 in outbreak settings // Disclaimer Eur Radiol. 2020 Nov 4: 1–12. doi:10.1007/s00330-020-07401-8 PMCID:PMC7610169 PMID:33146796CT
25. Wang Y., Liu Y., Liu L., Wang X., Luo N., Ling L. Clinical outcome of 55 asymptomatic cases at the time of hospital admission infected with SARS-Coronavirus-2 in Shenzhen, China // J Infect Dis. (2020) 221:1770–4. doi: 10.1093/infdis/jiaa119.
26. Wu Z., McGoogan J.M. Characteristics and important lessons of the 2019 coronavirus outbreak (COVID-19) in China: summary of the report of the Chinese center for disease control and prevention on 72314 cases // JAMA 2020; 323 : 1239–42.
27. www.coronavirus2020.kz, (дата обращения: 29.01.2021).
28. Xiangming Meng, Yanzhong Deng, Zhiyong Dai, and Zhisheng Mengc COVID-19 and anosmia: A review based on up-to-date knowledge // Am J Otolaryngol. 2020 September-October; 41(5): 102581. Published online 2020 Jun 2. doi: 10.1016/j.amjoto.2020.102581 PMCID: PMC7265845 PMID: 32563019
29. Xingfei Pan, Dexiong Chen, Yong Xia, Xinwei Wu, Tangsheng Li, Xueting Ou, Liyang Zhou, and Jing Liuf, Author information Copyright and License information Disclaimer Asymptomatic cases in a family cluster with SARS-CoV-2 infection // Lancet Infect Dis. 2020 Apr; 20(4): 410–411. Published online 2020 Feb 19. doi: 10.1016/S1473-3099(20)30114-6 PMCID: PMC7158985 PMID: 32087116
30. Xyz Zhi, Wang Y. et al. Covid-19 pathology data related to acute respiratory distress syndrome // Lancet Resp Med 2020; 8: 420–2.
31. Yang X., Xu Jet al. Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-center retrospective observational study // Lancet Resp Med 2020; 8: 475–81.
References:
1. Akimkin V.G., Kuzin S.N., Semenenko T.A., Ploskireva A.A., Dubodelov D.V., Tivanova E.V., Pshenichnaja N.Ju., Kalenskaja A.V. et al. Genderno-vozrastnaja harakteristika pacientov. [Gender and age characteristics of patients]. DOI: 10.21055/0370-1069-2020-3-27-35 UDK 616.98:578.2 [in Russian].
2. Akimkin V.G., Kuzin S.N., Semenenko T.A., Shipulina O.Ju., Jacyshina S.B., Tivanova E.V. et al. Zakonomernosti jepidemicheskogo rasprostranenija SARS-CoV-2 v uslovijah megapolisa. [Patterns of the epidemic spread of SARS-CoV-2 in a megalopolis]. Voprosy virusologii [Questions of virology]. 2020; 65(4):203–211. DOI: 10.36233/0507-4088-2020-65-4-203-211 [in Russian].
3. Ahmad R Sedaghat, Isabelle Gengler, Marlene M. Speth Review Otolaryngol Head Neck Surg. 2020 Jul;163(1):12-15. doi: 10.1177/0194599820926464. Epub 2020 May 5. Olfactory Dysfunction: A Highly Prevalent Symptom of COVID-19 With Public Health Significance Affiliations expand PMID: 32366160 DOI: 10.1177/0194599820926464.
4. CDC COVID-19 Response Team. Coronavirus Disease 2019 in Children – United States, February 12 – April 2, 2020. MMWR Morb. Mortal. Wkly Rep. 2020; 69(14):422–26. DOI: 10.15585/mmwr.mm6914e4.
5. Chun М., Zhou M, Dong X et al. Epidemiological and clinical characteristics of 99 cases of new coronavirus pneumonia 2019 in Wuhan, China: a descriptive study. Lancet. 2020; 395 :507-13.
6. Dhochak N., Singhal T., Kabra S.K., Lodha R. Pathophysiology of COVID-19: why children fare better than adults? Indian J Pediatr. 2020; 87(7):537–46. DOI: 10.1007/s12098-020- 03322-y.
7. Dong Y., Mo X., Hu Y., Qi X., Jiang F., Jiang Z., Tong S. Epidemiology of COVID-19 among children in China. Pediatrics. 2020; 145(6):e20200702.DOI: 10.1542/peds.2020-0702.
8. Gu H., Xie Z., Li T., Zhang S., Lai C. et al. Angiotensin-converting enzyme 2 inhibits lung injury induced by respiratory syncytial virus. Sci Rep. 2016. v.6. Р.19840
9. Guan W-j, Ni Z-y, Hu Y. et al. Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med 2020; 382 : 1708–20.
10. He f., Deng Y., Li V. Coronavirus disease 2019 (COVID-19): what do we know? J Med Virol 2020. 92 (7): 719-725, 14 March 2020.
11. He X., Lau E.H.Y., Wu P. et al (2020) Temporal dynamics in viral shedding and transmissibility of COVID-19. Nat Med. 10.1038/s41591-020-0869-5
12. Jerome R Lechien, Carlos M Chiesa-Estomba, Daniele R De Siati, Mihaela Horoi, Serge D Le Bon, Alexandra Rodriguez, Didier Dequanter, Serge Blecic, Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): a multicenter European study Affiliations expandю. Multicenter Study Eur Arch Otorhinolaryngol. 2020 Aug;277(8):2251-2261. doi: 10.1007/s00405-020-05965-1. Epub 2020 Apr 6.
13. Jiang F., Deng L., Zhang L., Cai Y., Cheung C.W., Xia Z. Review of clinical characteristics of coronavirus disease 2019 (COVID ‐ 19). J Gen Intern Med. 2020 May;35(5):1545-1549. doi: 10.1007/s11606-020-05762-w. Epub 2020 Mar 4.
14. Klopfenstein T., Kadiane-Oussou N.J., Toko L., Royer P.Y., Lepiller Q., Gendrin V. Features of anosmia in COVID-19. Med Mal Infect. 2020 doi: 10.1016/j.medmal.2020.04.006. [pii: S0399-077X(20)30110-4, Apr 17.
15. Lauer S.A., Grantz K.H., Bi K. et al . Incubation period of coronavirus disease 2019 (COVID-19) from officially registered confirmed cases: assessment and application. Ann Int Med. 2020; 172 : 577.
16. Li L.Q., Huang T., Wang Y.Q. et al 2019 novel coronavirus patients' clinical characteristics, discharge rate and fatality rate of meta‐analysis. J Med Virol. 2020; 92: 577–83.
17. Li Q., Guan X., Wu P., et al. Early Transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia. N Engl J Med. 2020;382:1199–1207. doi: 10.1056/NEJMoa2001316.
18. Luers J.C., Rokohl A.C., Loreck N., Wawer Matos P.A., Augustin M., Dewald F. Olfactory and gustatory dysfunction in coronavirus disease 19 (COVID-19). Clin Infect Dis. 2020 doi: 10.1093/cid/ciaa525, May 1.
19. Ludvigsson J.F. Systematic review of COVID-19 in children shows milder cases and a better prognosis than adults. Acta Paediatr. 2020; 109(6):1088–95. DOI: 10.1111/apa.15270.
20. Mizumoto K., Kagaya K., Zarebski A., Chowell G. Estimating the asymptomatic proportion of coronavirus disease 2019 (COVID-19) cases on board the Diamond Princess cruise ship, Yokohama, Japan, 2020. Euro Surveill. (2020) 25:2000180. doi: 10.2807/1560-7917.ES.2020.25.10.2000180.
21. She J., Liu L., Liu W. COVID-19 epidemic: disease characteristics in children. J. Med. Virol. 2020; 92(7):747–54. DOI: 10.1002/jmv.25807.
22. Singhal T.A. Review of Coronavirus Disease ‐2019 (COVID‐19). Indian J Pediatr. 2020; 87: 281–6.
23. Sun P., Lu X., Xu C., Sun W., Pan B. Understanding of COVID‐19 based on current evidence. J Med Virol. 2020; 92: 548–51.
24. Varble Nicole, Maxime Blain, Michael Kassin, Sheng Xu, Evrim B. Turkbey, Amel Amalou, Dilara Long, Stephanie Harmon et al. Author information Article notes Copyright and License information and clinical assessment in asymptomatic and pre-symptomatic patients with early SARS-CoV-2 in outbreak settings. Disclaimer Eur Radiol. 2020 Nov 4: 1–12. doi:10.1007/s00330-020-07401-8 PMCID:PMC7610169 PMID:33146796CT
25. Wang Y., Liu Y., Liu L., Wang X., Luo N., Ling L. Clinical outcome of 55 asymptomatic cases at the time of hospital admission infected with SARS-Coronavirus-2 in Shenzhen, China. J Infect Dis. (2020) 221:1770–4. doi: 10.1093/infdis/jiaa119.
26. Wu Z., McGoogan J.M. Characteristics and important lessons of the 2019 coronavirus outbreak (COVID-19) in China: summary of the report of the Chinese center for disease control and prevention on 72314 cases. JAMA. 2020; 323 : 1239–42.
27. www.coronavirus2020.kz, (дата обращения: 29.01.2021).
28. Xiangming Meng, Yanzhong Deng, Zhiyong Dai, and Zhisheng Mengc COVID-19 and anosmia: A review based on up-to-date knowledge. Am J Otolaryngol. 2020 September-October; 41(5): 102581. Published online 2020 Jun 2. doi: 10.1016/j.amjoto.2020.102581 PMCID: PMC7265845 PMID: 32563019
29. Xingfei Pan, Dexiong Chen, Yong Xia, Xinwei Wu, Tangsheng Li, Xueting Ou, Liyang Zhou, and Jing Liuf, Author information Copyright and License information Disclaimer Asymptomatic cases in a family cluster with SARS-CoV-2 infection. Lancet Infect Dis. 2020 Apr; 20(4): 410–411. Published online 2020 Feb 19. doi: 10.1016/S1473-3099(20)30114-6 PMCID: PMC7158985 PMID: 32087116
30. Xyz Zhi, Wang Y. et al. Covid-19 pathology data related to acute respiratory distress syndrome. Lancet Resp Med. 2020; 8: 420–2.
31. Yang X., Xu Jet al. Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-center retrospective observational study. Lancet Resp Med 2020; 8: 475–81.
Количество просмотров: 536
Категория статей:
Актуальная тема COVID-19
Библиографическая ссылка
Mynzhanova A., Baesheva D.A., Omarova A.K., Khamitova M.O., Daulbaeva A.U., Turdalina B.R., Seidullayeva A.Zh., Zhuzzhasarova A.A., Altynbekova A.V., Kirpicheva U.A., Kushugulova A.А., Kozhakhmetov S.S. Analysis of the implementation of clinical manifestations of COVID-19 in contact persons // Nauka i Zdravookhranenie [Science & Healthcare]. 2021, 1 (Vol.23), pp. 5-14. doi 10.34689/SH.2021.23.1.001Похожие публикации:
CONSEQUENCES OF THE CORONAVIRUS INFECTION: THE POST-COVID SYNDROME AND MENTAL MANIFESTATIONS. LITERATURE REVIEW
EFFICACY OF THE ANTIVIRAL DRUG ENISAMY IODIDE IN SEVERE ADULT ACUTE RESPIRATORY INFECTIONS IN THE COVID-19 ERA
КЛИНИЧЕСКИЕ И СОЦИАЛЬНО-ДЕМОГРАФИЧЕСКИЕ ХАРАКТЕРИСТИКИ ПАЦИЕНТОВ С ПСИХИЧЕСКИМИ И ПОВЕДЕНЧЕСКИМИ РАССТРОЙСТВАМИ В ПОСТКОВИДНОМ ПЕРИОДЕ
ИММУНОЛОГИЧЕСКИЕ ИЗМЕНЕНИЯ У ДЕТЕЙ С МУЛЬТИСИСТЕМНЫМ ВОСПАЛИТЕЛЬНЫМ СИНДРОМОМ, АССОЦИИРОВАННЫМ С SARS-COV-2
КЛИНИЧЕСКАЯ КАРТИНА COVID-19 У ВЗРОСЛЫХ ПАЦИЕНТОВ ТУРКЕСТАНСКОЙ ОБЛАСТИ В ЗАВИСИМОСТИ ОТ СОПУТСТВУЮЩИХ ЗАБОЛЕВАНИЙ