HEALTH STATUS IN PERSONS OF REPRODUCTIVE AGE WITH METABOLIC SYNDROME
Introduction. As noted in the state program for the development of healthcare of the Republic of Kazakhstan for 2020-2025, the emphasis on non – communicable diseases with high prevalence rates and prone to steady growth is one of the characteristic features of healthcare in Kazakhstan and all developed countries. Among the signs important for understanding health, a special place is occupied by the state of health of the population of reproductive age. Since it is a necessary condition for the well-being of future generations and the guarantee of a sufficient population in the state.
Objective: To determine the health condition of the reproductive age people of suffering from MS.Methods. Study design: observational, simultaneous, case-control. The study involved 1065 people aged 18 to 49 years, the average age was 40.2 years. Metabolic syndrome in respondents was determined according to the IDF criteria (2005). Statistical analysis was performed in the SPSS 24 program. Pearson's test, χ2, Welch T test in two samples, non-parametric Mann-Whitney test for independent groups were performed. The statistical reliability of the indicators was assessed at the level of p <0.05.
Research results. Hemogram indices, lipid profile, body weight, waist volume, visceral fat index, liver enzymes, renal function indices, the state of the common carotid artery layers, biological age indices and the aging rate coefficient were higher in study participants with metabolic syndrome compared with respondents without metabolic syndrome ( p <0.05).
Conclusion. Thus, it was found that patients with metabolic syndrome suffer from obesity, which is accompanied by an excessive accumulation of visceral fat, an increase in the waist volume and body mass index. In patients with metabolic syndrome, the functions of the liver, kidneys, heart are impaired, and the indices of general clinical and biochemical blood tests are changed. In connection with these changes, a greater biological age of patients was revealed, i.e., a faster aging process. In addition, individuals with metabolic syndrome were found to have abnormalities in the structure of the heart and changes in the carotid artery, leading to atherosclerosis.
Kamshat Akhmetova 1-2, https://orcid.org/0000-0003-4225-3025
Таmara Vochshenkova 1, https://orcid.org/0000-0003-0935-6217
Еrbolat Dalenov 2, https://orcid.org/0000-0002-7009-583X
Аigul Abduldayeva 2, https://orcid.org/0000-0002-1310-3290
1 Medical Center Hospital of the President’s Affairs Administration of the Republic of Kazakhstan,
Nur-Sultan c., Republic of Kazakhstan.
2 Astana Medical University, Nur-Sultan c., Republic of Kazakhstan.
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8. Amato M.C. et al. Cut-off points of the visceral adiposity index (VAI) identifying a visceral adipose dysfunction associated with cardiometabolic risk in a Caucasian Sicilian population. Lipids Health Dis. 2011. 10: p. 183.
9. Bo S. Et al. Associations between gamma-glutamyl transferase, metabolic abnormalities and inflammation in healthy subjects from a population-based cohort: a possible implication for oxidative stress. World J Gastroenterol. 2005. 11(45): p. 7109-17.
10. Cerhan J.R. et al. A pooled analysis of waist circumference and mortality in 650,000 adults // Mayo Clin Proc. 2014. 89(3): p. 335-45.
11. Declaration of Helsinki: Ethical Principles for Medical Research Involving Human Subjects, JAMA. 2013. 310 (20): p. 2191–2194. PMID 24141714, doi:10.1001/jama.2013.281053
12. Girona J. Et al. HDL Triglycerides: A New Marker of Metabolic and Cardiovascular Risk. Int J Mol Sci. 2019. 20(13).
13. Çakırca G., Çelik M.M. Lipid profile and atherogenic indices and their association with platelet indices in familial Mediterranean fever. Turk Kardiyol Dern Ars. 2018. 46(3): p. 184-190.
14. Hiam D., Patten R. et.al. The effectiveness of high intensity intermittent training on metabolic, reproductive and mental health in women with polycystic ovary syndrome: study protocol for the iHIT- randomised controlled trial. Trials. 2019. 20: p. 221.
15. Hämäläinen P. et al. Hemoglobin level and lipoprotein particle size. Lipids Health Dis. 2018. 17(1): p. 10.
16. Kälsch J. et al. Normal liver enzymes are correlated with severity of metabolic syndrome in a large population based cohort. Sci Rep. 2015. 5: p. 13058.
17. Lam D., LeRoith D. Metabolic syndrome. In: Feingold K.R. Anawalt B., Boyce A. Et al eds. Endotext [Internet]. South Dartmouth, MA: MDText.com, Inc; 2000. https://www.ncbi.nlm.nih.gov/books/NBK278936/
18. Lorenz M.W. et al. Prediction of clinical cardiovascular events with carotid intima-media thickness: a systematic review and meta-analysis. Circulation. 2007. 115(4): p. 459-67.
19. Nikniaz L. et al. Is within-normal range liver enzymes associated with metabolic syndrome in adults? Clin Res Hepatol Gastroenterol. 2018. 42(1): p. 92-98.
20. Ranasinghe P., et al. Prevalence and trends of metabolic syndrome among adults in the asia-pacific region: a systematic review. BMC Public Health. 2017. 17(1): p. 101.
21. Tanaka K. et al. The relationship between body mass index and uric acid: a study on Japanese adult twins. Environ Health Prev Med. 2015. 20(5): p. 347-53.
22. World Health Organization. The world health report 2002 – Reducing Risks, Promoting Healthy Life. World Health Organization. 2002. P. 240.
23. Wildman R.P. et al.,The obese without cardiometabolic risk factor clustering and the normal weight with cardiometabolic risk factor clustering: prevalence and correlates of 2 phenotypes among the US population (NHANES 1999-2004). Arch Intern Med. 2008. 168(15): p. 1617-24.
24. Würtz P. et al. Metabolite profiling and cardiovascular event risk: a prospective study of 3 population-based cohorts. Circulation. 2015. 131(9): p. 774-85.
25. Yadav D. et al. Combined Effect of Initial and Longitudinal Increases in γ-Glutamyltransferase on Incident Metabolic Syndrome: ARIRANG Study. Yonsei Med J. 2017. 58(4): p. 763-769.
26. Zhang Y. et al. Non-HDL-C is a Better Predictor for the Severity of Coronary Atherosclerosis Compared with LDL-C. Heart Lung Circ. 2016. 25(10): p. 975-81.
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Akhmetova K., Vochshenkova Т., Dalenov Е., Abduldayeva А. Health status in persons of reproductive age with metabolic syndrome // Nauka i Zdravookhranenie [Science & Healthcare]. 2021, (Vol.23) 4, pp. 130-137. doi 10.34689/SH.2021.23.4.014Похожие публикации:
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