TREATMENT OF HEEL PAIN WITH MINERAL SALTS EXCHANGE: PROTOCOL FOR A CLINICAL PILOT STUDY
Introduction: The pain of the Achilles tendon and heel (ATHP) is a major concern, particularly for athletes, military people, and ordinary workers badly using inferior arts. Mineral displacement therapy to rescue the correct mineral balance in the osteoarticular districts can ameliorate heel pain. Methods: The present study investigated if treatment with mineral salts in subjects suffering from ATHP can rescue their normal health and decrease pain. A cohort of 15 persons, aged 50-65 years equally sex distributed, suffering from chronic heel pain, underwent the administration of 5.0 mg copper sulfate and 200 mg disodium-hydrogen-orthophosphate (with 500 mg of ascorbate) dissolved separately in 100 ml of drinking water as a daily beverage, morning/evening one hour after meals for three weeks. In the study, pain perception was the main outcome measure. Results: Mineral treatment improved ATHP with a different trend according to age and sex distribution. The scores of pain perception showed differential sensitivity among different genders. No one of the patients in the study experienced a relapse during the two years of follow-up. Conclusions: The present study showed that the therapeutic supplementation with displaced minerals might address the concern of heel pain in males and females with encouraging results in the early elderly population. Placebo-controlled such trials involving large populations with monitoring of blood/hair mineral profiles are suggested and further recommended. Monitoring of quantitative mineral profiles in blood and hair should be considered during medications for any ill effects.
Kundan Singh Dhillon1, http://orcid.org/0000-0003-4038-3248 Jasmer Singh2, http://orcid.org/0000-0002-3103-4698 Salvatore Chirumbolo3, http://orcid.org/ 0000-0003-1789-8307 Max Stanley Chartrand4, http://orcid.org/ 0000-0002-0613-0215 Jarnail Singh Lyall1, http://orcid.org/ 0000-0001-7439-5955 Geir Bjørklund5*, http://orcid.org/ 0000-0003-2632-3935 1 Punjab Agricultural University, Ludhiana, Punjab, India; 2 Guru Angad Dev Veterinary and Animal Sciences University, Ludhiāna, India; 3 Department of Neurological and Movement Sciences, University of Verona, Verona, Italy; 4 DigiCare Institute for Behavioral Research, Casa Grande, AZ, USA; 5 Council for Nutritional and Environmental Medicine, Mo i Rana, Norway.
1. Alfredson H. Chronic midportion Achilles tendinopathy: an update on research and treatment // Clin Sports Med. 2003. № 22. Р. 727-741. 2. Alfredson H., Thorsen K., Lorentzon R. In situ microdialysis in tendon tissue: high levels of glutamate, but not prostaglandin E2 in chronic Achilles tendon pain // Knee Surg Sports Traumatol Arthrosc. 1999. №7. Р.378-381. 3. Benjamin M., Moriggl B., Brenner E., Emery P., McGonagle D., Redman S. The “enthesis organ” concept: why enthesopathies may not present as focal insertional disorders // Arthritis Rheum. 2004. №50. Р. 3306-3313. 4. Brewer G.J. Zinc and tetrathiomolybdate for the treatment of Wilson’s disease and the potential efficacy of anticopper therapy in a wide variety of diseases // Metallomics. 2009. №1. Р. 199-206. 5. General Assembly of the World Medical Association. World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects // J Am Coll Dent. 2014. №81. Р. 14-18. 6. Hou G., Dick R., Brewer G.J. Improvement in dissolution of liver fibrosis in an animal model by tetrathiomolybdate // Exp Biol Med (Maywood). 2009. № 234. Р. 662-665. 7. Jozsa L., Balint J., Kannus P., Jarvinen M., Lehto M. Mechanoreceptors in human myotendinous junction // Muscle Nerve. 1993. №16. Р. 453-457. 8. Karousou E., Ronga M., Vigetti D., Passi A., Maffulli N. Collagens, proteoglycans, MMP-2, MMP-9 and TIMPs in human achilles tendon rupture // Clin Orthop Relat Res. 2008. № 466. Р. 1577-1582. 9. Khan K.M., Cook J.L., Maffulli N., Kannus P. Where is the pain coming from in tendinopathy? It may be biochemical, not only structural, in origin // Br J Sports Med. 2000. № 34. 81-83. 10. Lemont H., Ammirati K.M., Usen N. Plantar fasciitis: a degenerative process (fasciosis) without inflammation // J Am Podiatr Med Assoc. 2003. № 93. Р. 234-237. 11. Mendel R.R. The molybdenum cofactor // J Biol Chem. 2013. №288. Р. 13165-13172. 12. Phillips A., McClinton S. Gait deviations associated with plantar heel pain: A systematic review // Clin Biomech (Bristol, Avon). 2017. №42. Р. 55-64. 13. Pingel J., Fredberg U., Qvortrup K., Larsen J.O., Schjerling P., Heinemeier K. Local biochemical and morphological differences in human Achilles tendinopathy: a case control study // BMC Musculoskelet Disord. 2012. №13. Р. 53. 14. Quemeneur A.S., Trocello J.M., Ea H.K., Ostertag A., Leyendecker A., Duclos-Vallee J.C. Bone status and fractures in 85 adults with Wilson’s disease // Osteoporos Int. 2014. № 25. Р. 2573-2580. 15. Sharma P., Maffulli N. Biology of tendon injury: healing, modeling and remodeling // J Musculoskelet Neuronal Interact. 2006. № 6. Р. 181-190. 16. Shaw H.M., Santer R.M. Watson A.H., Benjamin M. Adipose tissue at entheses: the innervation and cell composition of the retromalleolar fat pad associated with the rat Achilles tendon // J Anat. 2007. №211. Р. 436-443. 17. Thomas J.L., Christensen J.C., Kravitz S.R., Mendicino R.W., Schuberth J.M, Vanore J.V. The diagnosis and treatment of heel pain: a clinical practice guideline-revision //J Foot Ankle Surg 2010. 49. S1-19. 18. Van Linthoudt D., Gerster J.C. Acute heel pain related to apatite deposition in the plantar fascia // Joint Bone Spine. 2013. № 80. Р. 344-345.
Количество просмотров: 283

Ключевые слова:


Библиографическая ссылка

Dhillon K.S., Singh J., Chirumbolo S., Chartrand M.S., Lyall J.S., Bjørklund G. Treatment of heel pain with mineral salts exchange: protocol for a clinical pilot study // Nauka i Zdravookhranenie [Science & Healthcare]. 2021, (Vol.23) 5, pp. 118-124. doi 10.34689/SH.2021.23.5.014

Авторизируйтесь для отправки комментариев