THE RELATIONSHIP BETWEEN TYPES OF OBESITY AND TESTOSTERONE LEVELS IN MEN WITH AGE-RELATED HYPOGONADISM FROM KAZAKH POPULATION
Introduction. Overweight and obesity are stated to be pressing clinical and social health problems around the world. This is a complex disease that develops as a result of genetic factors and environmental factors. At the same time, an important feature of obesity in men is a change in the metabolism of sex hormones. Age-related hypogonadism against the background of overweight is a clinical and biochemical syndrome that leads to a significant decrease in the quality of life and negatively affects the function of many systems and organs of an aging organism.
The study under consideration is aimed at assessing the effect of excess weight on the level of testosterone fraction and lipid metabolism in older men of the Kazakh population. In total, the study included 300 men who underwent a comprehensive clinical examination to determine the presence of hypogonadism. The surveyed were stratified by BMI, and divided into 3 groups: with a normal BMI up to 25 kg / m2 (group 1, n = 145), with an overweight BMI from 25-29.9 kg / m2 (group 2, n = 70) and with obesity BMI from 30 kg / m2 and more (group 3, n = 85).
Results. Total testosterone levels are directly related to SHBG concentration, so changes in blood SHBG levels affect plasma distribution of testosterone and its availability to target tissues and cells. In our studies, the percentage of free testosterone correlated negatively with total testosterone, SHBG, and BMI. But by the outcomes of the study, the calculated free testosterone was stated higher in groups with high BMI. But the reference value of free testosterone according to the literature data was directly proportional to the level of total testosterone and BMI. Our study has revealed a direct correlation between BMI and triglyceride and LDL levels, and an inverse relationship with HDL levels.
Conclusion. Overweight and obesity are accompanied by a decrease in SHBG and total testosterone levels and their decrease correlates to obesity degree. Although the calculated free testosterone do not have a solid biological basis, they are entirely suitable to be applied in andrological practice. Lipid metabolism disorders are more often caused by lifestyle and ethnic food habits.
Merkhat N. Akkaliev1, https://orcid.org/0000-0003-3122-7411
Nurlan Ye. Aukenov2, http://orcid.org/0000-0002-3163-2997
Meruyert R. Massabayeva1, https://orcid.org/0000-0001-8240-361Х
Saule O. Rakhyzhanova1, https://orcid.org/0000-0001-5507-0610
Bakytbek А. Apsalikov1, https://orcid.org/0000-0001-6983-9224
Ainur S. Krykpayeva1, Nariman M. Sadykov3,
Muratkhan T. Kuderbaev1, https://orcid.org/0000-0002-7431-6273
1 NCJSC "Semey Medical University", Semey, Republic of Kazakhstan;
2 Department of Health and Human Resources, Ministry of Health of the Republic of Kazakhstan,
Nur-Sultan, Republic of Kazakhstan;
3 Pavlodar Branch of the Semey Medical University, Pavlodar, Republic of Kazakhstan.
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Akkaliev M.N., Aukenov N.Ye., Massabayeva M.R., Rakhyzhanova S.O, Apsalikov B.А., Krykpayeva A.S., Sadykov N.M., Kuderbaev M.T. The relationship between types of obesity and testosterone levels in men with age-related hypogonadism from Kazakh population // Nauka i Zdravookhranenie [Science & Healthcare]. 2021, (Vol.23) 5, pp. 125-131. doi 10.34689/SH.2021.23.5.015Похожие публикации:
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