CAUSAL RISK FACTORS FOR MACROSOMIA OF NEWBORNS WITH VITAMIN D DEFICIENCY
Relevance: In the modern world, the frequency of macrosomia is growing dynamically. The World Health Organization (WHO) has recognized obesity, type 2 diabetes mellitus and non-communicable diseases as global epidemics [2]. Macrosomia is defined as a birth weight of more than 4000 g regardless of gestational age and occurs in 3-15% of all pregnancies worldwide [4,9,22]. Vitamin D deficiency during pregnancy is associated with an increased risk of gestational diabetes and preeclampsia, which may indirectly affect the health of offspring [5,6,21].
Objective: To assess risk factors and the level of vitamin D in umbilical cord blood in macrosomal newborns.
Materials and methods of research. Case - control. The study was conducted in the period from January 2021 to April 2021 at the clinical bases "Perinatal Center of Semey and Ust-Kamenogorsk. The study included full-term newborns in the number of 100 children. Informational consents were received from mothers of newborns to participate in the study. The mothers were informed about the processing of the received data, with the subsequent publication of the research results, without specifying personal data. Inclusion criteria: full-term children with macrosomia. Exclusion criteria: children with defects, genetic diseases, premature newborns.
The data analysis was carried out using the SPSS package version 20.0. To check the statistical significance of the differences between the group of "cases" and "controls", the Pearson and Mann-Whitney χ2 criterion was used, and the odds ratio is calculated taking into account the 95% confidence interval. Continuous data is presented in the form of (Me) and standard deviation (CD).
Results: According to the results of the analysis of risk factors, the cause of macrosomia was maternal diabetes mellitus. The study showed that the pronounced vitamin D deficiency in serum was significantly lower in patients with macrosomia compared to normal-weight children.
Conclusion: the leading risk factor for macrosomia was diabetes mellitus of pregnant women. In newborns with macrosomia, a pronounced deficiency of 25(OH) D.
Nazym М. Ailbayeva1, https://orcid.org/0000-0003-1700-9696
Aliya R. Alimbaeva1, https://orcid.org/0000-0002-5082-4636
Sayat Z. Tanatarov1, https://orcid.org/0000-0001-8958-8768
Dinara О. Ahmetzhanova1, https://orcid.org/0000-0003-0000-2535
Yuri F. Lobanov2, https://orcid.org/0000-0001-6284-1604
Gulnarа B. Taiorazova1, https://orcid.org/0000-0002-8450-9204
Duman Berikuly1, https://orcid.org/0000-0002-9738-7453
Aziza K. Nurgazinova1, https://orcid.org/0000-0002-3181-5347
1 NJSC «Semey Medical University», Semey, Republic of Kazakhstan;
2 Altai State Medical University, Barnaul, Russian Federation.
1. Abolfazl M., Hamidreza T.S., Narges M.Y. Gestational diabetes and its association with unpleasant outcomes of pregnancy // Pak J Med Sci. 2008. 24:566–70.
2. Akanmode A.M., Macrosomia M.H. [Updated 2022 Sep 9]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan. Available from: https://www.ncbi.nlm.nih.gov/books/NBK557577/ (Дата обращения: 07.09.2022)
3. American College of Obstetricians and Gynecologists’ Committee on Practice Bulletins—Obstetrics. Practice Bulletin No. 173: Fetal Macrosomia // Obstet Gynecol. 2016 Nov. 128(5):e195-e209
4. Asplund C.A., Seehusen D.A., Callahan T.L., Olsen C. Percentage change in antenatal body mass index as a predictor of neonatal macrosomia // Ann Fam Med. 2008. 6:550–4.
5. Brannon P.M., Vitamin D., and adverse pregnancy outcomes: beyond bone health and growth // Proceedings of the Nutrition Society 2012. 71. 205-212. https://doi.org/10.1017/S0029665111003399
6. Bodnar L.M., Catov Janet M., Simhan Hyagriv N., Holick Michael F., Powers Robert W., Roberts James M. Maternal Vitamin D Deficiency Increases the Risk of Preeclampsia // The Journal of Clinical Endocrinology & Metabolism, 2007. 92(9), 3517–3522. doi:10.1210/jc.2007-0718 (Дата обращения: 09.09.2022)
7. Boulet S.L., Alexander G.R., Salihu H.M., Pass M. Macrosomic births in the United States: determinants, outcomes, and proposed grades of risk // Am J Obstet Gynecol. 2003 May. 188(5):1372-8. doi: 10.1067/mob.2003.302. PMID: 12748514.
8. Catalano P.M., Hauguel-De Mouzon S. Is it time to revisit the Pedersen hypothesis in the face of the obesity epidemic? // Am J Obstet Gynecol. 2011 Jun. 204(6):479-87.
9. Harvey L., van Elburg R., van der Beek E.M. Macrosomia and large for gestational age in Asia: One size does not fit all // J Obstet Gynaecol Res. 2021 Jun. 47(6):1929-1945. doi: 10.1111/jog.14787. PMID: 34111907.
10. Health Study II. Prev Chronic Dis. 2013 Sep 19. 10:E156. doi: 10.5888/pcd10.120336. PMID: 24050526. PMCID: PMC3780709.
11. He X.J., Qin F.Y., Hu C.L., Zhu M, Tian C.Q., Li L. Is gestational diabetes mellitus an independent risk factor for macrosomia: a meta-analysis? // Arch Gynecol Obstet. 2015 Apr. 291(4):729-35. doi: 10.1007/s00404-014-3545-5. Epub 2014 Nov 12. PMID: 25388922.
12. Holick M.F., Binkley N.C., Bischoff-Ferrari H.A. Endocrine Society. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline // J Clin Endocrinol Metab 2011. Dec. 96(12):3908. PMID: 21646368.
13. James-Todd T.M., Karumanchi S.A., Hibert E.L., Mason S.M., Vadnais M.A., Hu F.B., Rich-Edwards J.W. Gestational age, infant birth weight, and subsequent risk of type 2 diabetes in mothers: Nurses' Health Study II. Prev Chronic Dis. 2013 Sep 19-10: E156. doi: 10.5888/pcd10.120336. PMID: 24050526; PMCID: PMC3780709. (Дата обращения:08.09.2022)
14. Kerényi Z., Tamás G., Kivimäki M., Péterfalvi A., Madarász E., Bosnyák Z. Maternal glycemia and risk of large-for-gestational-age babies in a population-based screening // Diabetes Care. 2009. 32:2200–5.
15. Krishnaveni G.V., Veena S.R., Winder N.R., Hill J.C., Noonan K., Boucher B.J., Karat S.C., Fall C.H. Maternal vitamin D status during pregnancy and body composition and cardiovascular risk markers in Indian children: the Mysore Parthenon Study // American Journal of Clinical Nutrition. 2011. 93. 628-635. https://doi.org/10.3945/ajcn.110.003921) (Дата обращения: 30.08.2022)
16. Macrosomia: ACOG Practice Bulletin, Number 216 // Obstet Gynecol. 2020 Jan. 135(1):e18-e35. doi: 10.1097/AOG.0000000000003606. PMID: 31856124.
17. Mohammadbeigi A., Farhadifar F., Soufi Zadeh N., Mohammadsalehi N., Rezaiee M., Aghaei M. Fetal macrosomia: risk factors, maternal, and perinatal outcome // Ann Med Health Sci Res. 2013. Oct. 3(4):546-50.
18. Mondestin M.A.J., Ananth C.V., Smulian J.C., Vintzileos A.M. Birth weight and fetal death in the United States: the effect of maternal diabetes during pregnancy // American Journal of Obstetrics and Gynecology. 2002. 187(4):922–926.
19. Ng S.K., Olog A., Spinks A.B., Cameron C.M., Searle J., Mc Clure R.J. Risk factors and obstetric complications of large for gestational age births with adjustments for community effects: Results from a new cohort study // BMC Public Health. 2010. 10:460.
20. Nkwabong E., Nzalli Tangho G.R. Risk Factors for Macrosomia // J Obstet Gynaecol India. 2015. Jul, 65(4): 226-9.
21. Senti J., Thiele D.K., Anderson C.M. Maternal vitamin D status as a critical determinant in gestational diabetes // Journal of Obstetric, Gynecologic, and Neonatal Nursing. 2012. 41. 328-338. https://doi.org/10.1111/j.1552-6909.2012.01366.x Дата обращения: 02.09.2022)
22. Zheng W., Zhang L., Tian Z.H., et al. Analysis of population attributable risk of large for gestational age // Zhonghua Fu Chan Ke Za Zhi. 2019. Dec 25.54(12) :833-839. Chinese. doi:10.3760/cma.j.issn.0529-567x.2019.12.007. PMID: 31874473.
23. Zhu L., Wen J., Kang C., Wang J., Cui X. et al. Association of maternal serum 25-hydroxyvitamin D concentrations in second and third trimester with risk of macrosomia // Sci Rep. 2018. Apr 18. 8(1):6169. doi: 10.1038/s41598-018-24534-5. PMID: 29670182; PMCID: PMC5906563.
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Ailbayeva N.М., Alimbaeva A.R., Tanatarov S.Z., Ahmetzhanova D.О., Lobanov Yu.F., Taiorazova G.B., Berikuly D., Nurgazinova A.K. Causal risk factors for macrosomia of newborns with vitamin D deficiency // Nauka i Zdravookhranenie [Science & Healthcare]. 2022, (Vol.24) 6, pp. 65-70. doi 10.34689/SH.2022.24.6.009Похожие публикации:
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